Results 21 to 30 of about 238,772 (243)

CD4+ICOS+Foxp3+: a sub-population of regulatory T cells contribute to malaria pathogenesis

Malaria Journal, 2022
Background Regulatory T cells are known to play a key role to counter balance the protective immune response and immune mediated pathology. However, the role of naturally occurring regulatory cells CD4+CD25+Foxp3 + in malaria infection during the disease
Rubika Chauhan, Vikky Awasthi, Reva Sharan Thakur, Veena Pande, Debprasad Chattopadhyay, Jyoti Das   +5 more
doaj   +1 more source

Insecticide resistance of Anopheles sinensis after elimination of malaria in Henan Province, China

Parasites & Vectors, 2023
Background Historically, malaria due to Plasmodium vivax has been epidemic in Henan Province, China, with Anopheles sinensis as the main vector. The most effective measures to prevent malaria transmission are based on vector control through the use of ...
Zhi-quan He, Ya-bo Hu, Dan Wang, Yu-ting Liu, Cheng-yun Yang, Dan Qian, Rui-min Zhou, De-ling Lu, Su-hua Li, Ying Liu, Hong-wei Zhang   +10 more
doaj   +1 more source

The spectrum of clinical biomarkers in severe malaria and new avenues for exploration

Virulence, 2022
Globally, malaria is a public health concern, with severe malaria (SM) contributing a major share of the disease burden in malaria endemic countries. In this context, identification and validation of SM biomarkers are essential in clinical practice. Some
Loick Pradel Kojom Foko, Geetika Narang, Suman Tamang, Joseph Hawadak, Jahnvi Jakhan, Amit Sharma, Vineeta Singh   +6 more
doaj   +1 more source

CRISPR/Cas9 Genome Editing Reveals That the Intron Is Not Essential for var2csa Gene Activation or Silencing in Plasmodium falciparum

mBio, 2017
Plasmodium falciparum relies on monoallelic expression of 1 of 60 var virulence genes for antigenic variation and host immune evasion. Each var gene contains a conserved intron which has been implicated in previous studies in both activation and ...
Jessica M. Bryant, Clément Regnault, Christine Scheidig-Benatar, Sebastian Baumgarten, Julien Guizetti, Artur Scherf   +5 more
doaj   +1 more source

Salivary glands harbor more diverse microbial communities than gut in Anopheles culicifacies

Parasites & Vectors, 2014
Background In recent years, it has been well documented that gut flora not only influence mosquito physiology, but also significantly alter vector competency.
Punita Sharma, Swati Sharma, Rakesh Kumar Maurya, Tanwee Das De, Tina Thomas, Suman Lata, Namita Singh, Kailash Chand Pandey, Neena Valecha, Rajnikant Dixit   +9 more
doaj   +1 more source

A testis-expressing heme peroxidase HPX12 regulates male fertility in the mosquito Anopheles stephensi

Scientific Reports, 2022
In vertebrates dysregulation of the antioxidant defense system has a detrimental impact on male fertility and reproductive physiology. However, in insects, especially mosquitoes the importance of sperm quality has been poorly studied.
Seena Kumari, Sanjay Tevatiya, Jyoti Rani, Tanwee Das De, Charu Chauhan, Punita Sharma, Rajkumar Sah, Shailja Singh, Kailash C. Pandey, Veena Pande, Rajnikant Dixit   +10 more
doaj   +1 more source

Comparison of the human-baited double net trap with the human landing catch for Aedes albopictus monitoring in Shanghai, China

Parasites & Vectors, 2018
Background Human landing catch (HLC) is the most efficient method for Aedes monitoring, but it is not ethical due to its high risk of human exposure to pathogens. We designed trials to assess the performance of an alternative human-baited double net trap
Qiang Gao, Fei Wang, Xihong Lv, Hui Cao, Jianjun Zhou, Fei Su, Chenglong Xiong, Peien Leng   +7 more
doaj   +1 more source

Transcriptional patterns of sexual dimorphism and in host developmental programs in the model parasitic nematode Heligmosomoides bakeri

Parasites & Vectors, 2023
Background Heligmosomoides bakeri (often mistaken for Heligmosomoides polygyrus) is a promising model for parasitic nematodes with the key advantage of being amenable to study and manipulation within a controlled laboratory environment.
Stephen M. J. Pollo, Aralia Leon-Coria, Hongrui Liu, David Cruces-Gonzalez, Constance A. M. Finney, James D. Wasmuth   +5 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

AN ESTERASE-LIKE PROTEIN (ELP) CONFERRED MALATHION AND DELTAMETHRIN RESISTANCE IN THE INDIAN FIELD POPULATION OF ANOPHELES STEPHENSI

International Journal of Infectious Diseases, 2023
Intro: Chemical insecticides in the form of IRS (Indoor Residual Sprays) and LLITNs (Long Lasting Insecticide Treated Nets) comprise current malaria vector control strategies.
J. Kumar, K. Prasad, V. Kumari, K. Pandey   +3 more
doaj   +1 more source