Results 51 to 60 of about 645,334 (303)

Transcriptional patterns of sexual dimorphism and in host developmental programs in the model parasitic nematode Heligmosomoides bakeri

Parasites & Vectors, 2023
Background Heligmosomoides bakeri (often mistaken for Heligmosomoides polygyrus) is a promising model for parasitic nematodes with the key advantage of being amenable to study and manipulation within a controlled laboratory environment.
Stephen M. J. Pollo, Aralia Leon-Coria, Hongrui Liu, David Cruces-Gonzalez, Constance A. M. Finney, James D. Wasmuth   +5 more
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Plasmodium falciparum Rosette Disruption Assay

Bio-Protocol, 2013
Rosetting, i.e. the capacity of Plasmodium falciparum-infected red blood cells (iRBCs) to bind two or more uninfected red blood cells (RBCs) is associated with severe malaria in African children.
Micheline Guillotte, Odile Mercereau-Puijalon, Inès Vigan-Womas   +2 more
doaj   +1 more source

Soil-transmitted helminths and schistosomiasis among pre-school age children in a rural setting of Busia County, Western Kenya: a cross-sectional study of prevalence, and associated exposures

BMC Public Health, 2020
Background Soil-transmitted helminths (STH) and schistosomiasis continue to cause serious health problems among affected communities. To ensure that infection transmission levels are reduced, repeated mass drug administration at regular intervals has ...
Janet Masaku, Doris W. Njomo, Ann Njoka, Collins Okoyo, Faith M. Mutungi, Sammy M. Njenga   +5 more
doaj   +1 more source

Spatial structures in a simple model of population dynamics for parasite-host interactions

, 2015
Spatial patterning can be crucially important for understanding the behavior of interacting populations. Here we investigate a simple model of parasite and host populations in which parasites are random walkers that must come into contact with a host in ...
Breecher, N., Dong, J. J., Schmittmann, B., Skinner, B., Zia, R. K. P.   +4 more
core   +1 more source

Population Pharmacokinetics and Pharmacodynamics of Artemether and Lumefantrine During Combination Treatment in Children with Uncomplicated Falciparum Malaria in Tanzania. [PDF]

, 2010
The combination of artemether (ARM) and lumefantrine is currently the first-line treatment of uncomplicated falciparum malaria in mainland Tanzania. While the exposure to lumefantrine has been associated with the probability of adequate clinical and ...
Annerberg, Anna, Ashton, Michael, Björkman, Anders, Dahlström, Sabina, Färnert, Anna, Gil, Pedro, Hietala, Sofia Friberg, Lindegårdh, Niklas, Mårtensson, Andreas, Ngasala, Billy, Premji, Zul   +10 more
core   +4 more sources

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Plasticity in transmission strategies of the malaria parasite, Plasmodium chabaudi : environmental and genetic effects [PDF]

, 2012
Parasites may alter their behaviour to cope with changes in the within-host environment. In particular, investment in transmission may alter in response to the availability of parasite resources or host immune responses.
Cameron, Angus, Drew, Damien R, Haydon, Daniel T, Reece, Sarah E, Yates, Andrew J   +4 more
core   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Seasonal epidemiology of gastrointestinal nematodes of cattle in the northern continental climate zone of western Canada as revealed by internal transcribed spacer-2 ribosomal DNA nemabiome barcoding

Parasites & Vectors, 2021
Background Gastrointestinal nematode (GIN) epidemiology is changing in many regions of the world due to factors such as global warming and emerging anthelmintic resistance.
Tong Wang, Elizabeth M. Redman, Arianna Morosetti, Rebecca Chen, Sarah Kulle, Natasha Morden, Christopher McFarland, Hannah Rose Vineer, Douglas D. Colwell, Eric R. Morgan, John S. Gilleard   +10 more
doaj   +1 more source