Results 51 to 60 of about 1,805,320 (364)

High content analysis of primary macrophages hosting proliferating Leishmania amastigotes: application to anti-leishmanial drug discovery.

open access: yesPLoS Neglected Tropical Diseases, 2013
Background/objectivesHuman leishmaniases are parasitic diseases causing severe morbidity and mortality. No vaccine is available and numerous factors limit the use of current therapies.
Nathalie Aulner   +10 more
doaj   +1 more source

Dendritic cell-mediated vaccination relies on interleukin-4 receptor signaling to avoid tissue damage after Leishmania major infection of BALB/c mice. [PDF]

open access: yesPLoS Neglected Tropical Diseases, 2012
Prevention of tissue damages at the site of Leishmania major inoculation can be achieved if the BALB/c mice are systemically given L. major antigen (LmAg)-loaded bone marrow-derived dendritic cells (DC) that had been exposed to CpG-containing ...
Anita Masic   +4 more
doaj   +1 more source

The role of defensive symbionts in host–parasite coevolution

open access: yesBiological Reviews of The Cambridge Philosophical Society, 2018
Understanding the coevolution of hosts and parasites is a long‐standing goal of evolutionary biology. There is a well‐developed theoretical framework to describe the evolution of host–parasite interactions under the assumption of direct, two‐species ...
C. Vorburger, S. Perlman
semanticscholar   +1 more source

Role of the Parasite and Host Cytoskeleton in Apicomplexa Parasitism [PDF]

open access: yesCell Host & Microbe, 2009
The phylum Apicomplexa includes a large and diverse group of obligate intracellular parasites that rely on actomyosin-based motility to migrate, enter host cells, and egress from infected cells. To ensure their intracellular survival and replication, the apicomplexans have evolved sophisticated strategies for subversion of the host cytoskeleton.
Frenal, Karine, Soldati-Favre, Dominique
openaire   +4 more sources

Toxoplasma effectors targeting host signaling and transcription [PDF]

open access: yes, 2017
Early electron microscopy studies revealed the elaborate cellular features that define the unique adaptations of apicomplexan parasites. Among these were bulbous rhoptry (ROP) organelles and small, dense granules (GRAs), both of which are secreted during
Ajioka JA   +23 more
core   +2 more sources

Empirical evidence that metabolic theory describes the temperature dependency of within-host parasite dynamics

open access: yesPLoS Biology, 2018
The complexity of host–parasite interactions makes it difficult to predict how host–parasite systems will respond to climate change. In particular, host and parasite traits such as survival and virulence may have distinct temperature dependencies that ...
D. Kirk   +6 more
semanticscholar   +1 more source

Identification and characterization of the Plasmodium vivax thrombospondin-related apical merozoite protein

open access: yesMalaria Journal, 2010
Background Malaria caused by Plasmodium vivax is a major public health problem worldwide that affects 70-80 million people in the Middle East, Asia, Western Pacific, South America and the Caribbean.
Villarreal-Gonzalez Silvana   +6 more
doaj   +1 more source

Network topology drives population temporal variability in experimental habitat networks

open access: yesPopulation Ecology, EarlyView.
Habitat patches connected by dispersal pathways form habitat networks. We explored how network topology affects population outcomes in laboratory experiments using a model species (Daphnia carinata). Central habitat nodes in complex lattice networks exhibited lower temporal variability in population sizes, suggesting they support more stable ...
Yiwen Xu   +3 more
wiley   +1 more source

Host lipid droplets: An important source of lipids salvaged by the intracellular parasite Toxoplasma gondii

open access: yesPLoS Pathogens, 2017
Toxoplasma is an obligate intracellular parasite that replicates in mammalian cells within a parasitophorous vacuole (PV) that does not fuse with any host organelles.
S. Nolan, J. Romano, I. Coppens
semanticscholar   +1 more source

Parasitism is always costly to the host

open access: yesZoological Research, 2021
Recent studies have examined the cost of raising parasitic cuckoos and highlighted the importance of "no extra cost" in explaining the low levels of defense in hosts. To clarify the reasons for parasitization in typical hosts, we present a simple model to explore the immediate and future costs of parasitism in shaping the evolution of defense behavior ...
Wei Liang, Nan Lyu
openaire   +3 more sources

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