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Biological and Molecular Characterization of Five Trypanosoma cruzi (Chagas, 1909) (Kinetoplastida, Trypanosomatidae) Isolates from the State of Hidalgo, Mexico [PDF]

open access: yesTropical Medicine and Infectious Disease
Trypanosoma cruzi, the causal agent of Chagas disease, exhibits great genetic diversity, which has been related to its biological properties. However, these are poorly known in strains from the endemic area of Hidalgo. To assess the parasite’s virulence,
Yessenia Montes-Vergara   +6 more
doaj   +2 more sources

Epidemiological characteristics of P. vivax asymptomatic infections in the Peruvian Amazon

open access: yesFrontiers in Cellular and Infection Microbiology, 2022
IntroductionHerein, we tested the hypothesis that Asymptomatic P. vivax (Pv) infected individuals (Asym) feature different epidemiological, clinical and biochemical characteristics, as well as hematological parameters, potentially predictive of clinical ...
Elizabeth Villasis   +17 more
doaj   +1 more source

Increased tumor necrosis factor alpha and interleukin-6 serum levels and their correlation with laboratory parameters in patients with imported malaria [PDF]

open access: yesArchives of Biological Sciences, 2012
In malaria, blood concentrations of proinflammatory cytokines, such as tumor necrosis factor alpha (TNF-α) and interleukin (IL)-6, are increased. In a study which included 34 patients, TNF-α and IL-6 were examined in two phases, immediately after the ...
Poluga Jasmina   +7 more
doaj   +1 more source

Mannose inhibits Plasmodium parasite growth and cerebral malaria development via regulation of host immune responses

open access: yesFrontiers in Immunology, 2022
D-mannose can be transported into a variety of cells via glucose transporter (GLUT), and supraphysiological levels of D-mannose impairs tumor growth and modulates immune cell function through mechanisms such as interference with glycolysis and induction ...
Li Lv   +7 more
doaj   +1 more source

Highly Sensitive and Rapid Quantitative Detection of Plasmodium falciparum Using an Image Cytometer

open access: yesMicroorganisms, 2020
The gold standard for malaria diagnosis is microscopic examination of blood films by expert microscopists. It is important to detect submicroscopic and asymptomatic Plasmodium infections in people, therefore the development of highly sensitive devices ...
Muneaki Hashimoto   +9 more
doaj   +1 more source

The Impact of Submicroscopic Parasitemia on Malaria Rapid Diagnosis in Northeastern Tanzania, an Area with Diverse Transmission Patterns

open access: yesInfectious Disease Reports, 2022
Global malaria epidemiology has changed in the last decade with a substantial increase in cases and deaths being recorded. Tanzania accounts for about 4% of all cases and deaths reported in recent years.
Robert Diotrephes Kaaya   +6 more
doaj   +1 more source

Efektivitas Kombinasi Artesunat-Klindamisin dengan Kinin-Klindamisin pada Pengobatan Malaria FalciparumTanpa Komplikasi pada Anak

open access: yesSari Pediatri, 2016
Latar belakang. Kombinasi antimalaria termasuk artemisinin sering tidak sesuai secara farmakokinetika sehingga berpotensi untuk resistensi. Untuk itu penilaian terhadap kombinasi artemisinin dengan obat yang mempunyai waktu paruh yang pendek diperlukan
Erika S. Panjaitan   +5 more
doaj   +1 more source

Parasitemia and Differential Tissue Tropism in Mice Infected with Trypanosoma cruzi Isolates Obtained from Meccus phyllosoma in the State of Oaxaca, Mexico

open access: yesPathogens, 2022
Trypanosoma cruzi is a parasite transmitted by the feces of triatomines. Many triatomine species are found in Mexico, and various T. cruzi variants have been isolated from these species, each showing very different virulence and cell tropism.
Any Laura Flores-Villegas   +10 more
doaj   +1 more source

Antimalarial evaluation of alkyl-linked bis-thiadiazine derivatives in murine model infected with two Plasmodium strains

open access: yesADMET and DMPK, 2023
Background and Purpose: Plasmodium falciparum and P. vivax are responsible for most malaria cases in humans in the African Region and the Americas; these parasites have developed resistance to classic antimalarial drugs.
Katherine Stefania Loachamin Gualotuña   +10 more
doaj   +1 more source

Trypanosoma brucei brucei is more pathogenic in rats compared to mice, making rats a better candidate for the relevant research studies [PDF]

open access: yesThe Iranian Journal of Veterinary Science and Technology, 2021
Trypanosomosis is an economically important disease that has raised great and diverse kinds of research using different types of animals. Hence, this study is aimed at determining the better laboratory animal between the Swiss albino mice and Wistar ...
Karimat Hussain   +4 more
doaj   +1 more source

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