Results 81 to 90 of about 13,284,007 (349)

SURVEILLANCE DATA ON BACTERIAL ENTEROCOLITIS IN BULGARIA FOR 2014-2018

Problems of Infectious and Parasitic Diseases, 2019
Worldwide, 30% of cases of infectious diarrhoea are caused by bacterial pathogens. As in other countries of the European Union, in Bulgaria the most common etiological agents are Escherichia coli (STEC), Salmonella spp., Shigella spp., Campylobacter spp.
Maria Pavlova, V. Velev, Miroslav Karageorgiev, Ekaterina Alexandrova, E. Kamenov, Todor Kantardjiev   +5 more
doaj   +1 more source

High vaccine confidence and strong approval of the mandatory immunization schedule among Bulgarian general practitioners in 2022

Human Vaccines & Immunotherapeutics, 2023
In a context of recently decreasing childhood immunization coverage and low uptake of COVID-19 vaccines in Bulgaria, this study measures vaccine hesitancy among general practitioners (GPs) in the country, as they are central to forming patients ...
Veronika Dimitrova, Savina Stoitsova, Vanya Rangelova, Ralitsa Raycheva, Maria Martinova, Gergana Nenova, Milena Iakimova, Irina Georgieva, Ivo Georgiev, Stefka Krumova, Antoaneta Minkova, Nadezhda Vladimirova, Lubomira Nikolaeva-Glomb   +12 more
doaj   +1 more source

Adaptation of Echinococcus Multilocularis to Oxidative Stress Depends on EmPDK‐Mediated Metabolic Reprogramming

Advanced Science, EarlyView.
Metabolic adaption presents a vital survival strategy for E. multilocularis. This study identifies EmPDK as a central metabolic regulator governing glucose metabolic reprogramming. Oxidative stress activates EmHIF1α to induce EmPDK expression. Mechanistic characterization reveals this ROS/EmHIF1α/EmPDK axis drives glycolytic reprogramming to sustain ...
Huijuan Wang, Zhijian Xu, Ye Tian, Yao Zhang, Zhe Cheng, Yanhai Wang   +5 more
wiley   +1 more source

Infectious and parasitic diseases of poultry in Ethiopia: a systematic review and meta-analysis

Poultry Science, 2019
In Ethiopia, poultry production is an important source of domestic food and nutrition security while providing income for nearly 80% of Ethiopians. However, several infectious and parasitic diseases hamper poultry production.
Yohannes T. Asfaw, G. Ameni, G. Medhin, G. Alemayehu, B. Wieland   +4 more
semanticscholar   +1 more source

Artificial Intelligence‐Guided Phenotypic Drug Repurposing Against Streptococcus pneumoniae

Advanced Science, EarlyView.
Integrated artificial intelligence (AI) ensembles identify highly potent repurposed drugs against Streptococcus pneumoniae. Prospective virtual screening of 6747 drugs uncovers nine active candidates, including thiostrepton. This drug exhibits low picomolar potency and bypasses established resistance in multidrug‐resistant strains, demonstrating an ...
Joshua S. Fitch, Muhammad D. Ariadi, Min Jung Kwun, Leonie Howells, Saiveth Hernandez‐Hernandez, Nicholas J. Croucher, Pedro J. Ballester   +6 more
wiley   +1 more source

UNEXPECTEDLY HIGH NUMBER OF WEST NILE NEUROINVASIVE DISEASES IN BULGARIA IN 2018

Problems of Infectious and Parasitic Diseases, 2018
West Nile virus (WNV) is an emerging arbovirus in Europe and America which disseminated widely in recent years. This study analysed epidemiological data and laboratory findings of probable and confirmed human WNV cases in Bulgaria in 2018. A total of 15
Iva Christova, Elitsa Panayotova, Iva Trifonova, Evgenia Taseva, Teodora Gladnishka   +4 more
doaj   +1 more source

A C‐Nucleoside Analogue of Cordycepin With High Metabolic Stability and Potent Anti‐Psoriatic Activity via Microneedle Delivery

Advanced Science, EarlyView.
This work identified CPD3a as a potent, stable C‐nucleoside cordycepin derivative. When formulated into microneedle array for topical treatment, it ameliorated psoriasis by rebalancing immunity and enhancing antioxidant defenses. ABSTRACT Psoriasis is a chronic inflammatory disorder characterized by immune dysregulation and epidermal hyperplasia ...
Wenfang Pan, Xinyue Shao, Yuanchen Zhong, Xujie Sun, Lixuan Yin, Zongyan He, Tianqun Lang, Yuanchao Xie   +7 more
wiley   +1 more source

Beyond Simple Mimicry: Next‐Generation Geometric Architectures and Future Paradigms in Small‐Molecule and Macrocyclic Peptidomimetics

Angewandte Chemie, EarlyView.
Peptide‐to‐Small Molecule Paradigm: Peptidomimetics have evolved from simple mimicry toward drug‐like scaffolds supported by increasing clinical successes. This Perspective highlights the geometric design principles—linear repetition, convergent fusion, and cyclization—defining the next‐generation peptidomimetic architectures capable of targeting ...
Jesang Lee, Sumin Son, Jeong Yeon Yoo, Ji Hyae Lee, Meehyun Chun, Seung Bum Park   +5 more
wiley   +2 more sources

Neglected parasitic infections in the United States [PDF]

Most people think of parasitic diseases occurring in poor and developing countries, something they might pick up on an overseas trip. However, parasitic infections still occur in the United States, and in some cases, affect millions of people. Often they

core   +2 more sources

DISTRIBUTION OF MYCOBACTERIUM AVIUM COMPLEX IN BULGARIA

Problems of Infectious and Parasitic Diseases, 2018
The members of Mycobacterium avium complex (MAC) are opportunistic microorganisms, common in the environment (soil and water) and cause infections in birds, mammals and humans.
Yuliana Atanasova, Stanislava Yordanova, Yana Todorova, Ana Baikova, Elizabeta Bachiyska   +4 more
doaj   +1 more source