Results 181 to 190 of about 44,736 (232)
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Parathyroid Hormone-Related Protein
Critical Reviews in Clinical Laboratory Sciences, 1995We review the current state of knowledge of the molecular properties and actions of parathyroid hormone-related protein (PTHrP) both in cancer patients and in normal physiology. PTHrP is a common product of squamous cancers and is the major mediator of the syndrome of humoral hypercalcemia of malignancy (HHM) by its actions through parathyroid hormone ...
Jane M. Moseley +2 more
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Parathyroid hormone‐related protein
Journal of Internal Medicine, 1993In 1987, a second member of the parathyroid hormone (PTH) family, PTH-related protein (PTHrP), was identified and cloned (1). PTHrP is produced in many normal fetal (2–11) and adult (7,12–19) tissues, including several endocrine tissues, cartilage and bone, heart, vascular and other smooth muscle, skin, central nervous system, liver, kidney, and lung ...
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Parathyroid Hormone-Related Protein
Mayo Clinic Proceedings, 1990Parathyroid hormone-related protein (PTH-rP) is a protein with potent parathyroid hormone (PTH)-like activity which acts on PTH receptors in bone and kidney with generation of cAMP. It was initially purified from the BEN lung tumour cell line and breast and renal carcinomas associated with hypercalcaemia (Moseley et al. 1987; Burtis et al.
W. A. Ratcliffe, J. G. Ratcliffe
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Parathyroid hormone-related protein and hypercalcemia
Cancer, 1997The discovery of parathyroid hormone-related protein (PTH-rP) arose from interest in the mechanisms by which certain cancers cause hypercalcemia without necessarily metastasizing to bone. The humoral hypercalcemia of malignancy (HHM) had for a long time been ascribed to inappropriate production of parathyroid hormone (PTH) by cancers.
W, Rankin, V, Grill, T J, Martin
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PARATHYROID HORMONE‐RELATED PROTEIN IN LOWER VERTEBRATES
Clinical and Experimental Pharmacology and Physiology, 1998SUMMARY1. Parathyroid hormone‐related protein (PTHrP) is an important mediator of humoral hypercalcaemia of malignancy in humans. Normal human subjects have very low levels of PTHrP in their circulation.2. Parathyroid hormone‐related protein has recently been demonstrated in high levels in the circulation and tissues of the sea bream and the dogfish ...
Danks, J. A. +5 more
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Parathyroid Hormone and Parathyroid hormone-Related Protein
The Biomedical & Life Sciences Collection, 2001Publisher Summary This chapter focuses on current understanding of the physiology and mechanism of action of these polypeptides. Parathyroid hormone (PTH) and PTH-related protein (PTHrP) are major factors that regulate skeletal physiology and mineral homeostasis.
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THE PARATHYROID HORMONE–RELATED PROTEIN
Endocrinology and Metabolism Clinics of North America, 2000Many physiologic roles of PTHrP are emerging. The protein functions locally in diverse tissues, often regulating the entry of cells into a differentiation pathway or acting as an epithelial signal in epithelial-mesenchymal interactions. To carry out these functions, PTHrP uses the receptor it shares with PTH or one of several PTHrP receptors that have ...
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Expression of parathyroid hormone-related protein in abnormal human parathyroids
Journal of Endocrinology, 1991ABSTRACT The expression of parathyroid hormone-related protein (PTHrP) in abnormal human parathyroids was investigated. Northern blot analysis of RNA extracted from human benign parathyroid adenomata (n = 4) revealed multiple PTHrP mRNA species ranging in size from 1·8 to 4kb.
H M, Docherty +3 more
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Ontogeny of Parathyroid Hormone-Related Protein in the Ovine Parathyroid Gland*
Endocrinology, 1991PTH-related protein (PTHrP) has been implicated in calcium regulation during fetal life. In this study the ontogeny of PTHrP was examined in ovine parathyroid glands. Immunohistochemical techniques, Western blot analysis, and a RIA with antisera raised against synthetic fragments of human (h) PTHrP (i.e.
R J, MacIsaac +7 more
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Primary hyperparathyroidism and parathyroid hormone-related protein
Current Opinion in Rheumatology, 1994Hypercalcemia is most commonly associated with primary hyperparathyroidism and malignancy due to parathyroid hormone-related protein (PTHrP). Primary hyperparathyroidism is characterized by excessive secretion of parathyroid hormone in association with hypercalcemia. The modern presentation of primary hyperparathyroidism is as an asymptomatic disorder.
M J, Horwitz, J P, Bilezikian
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