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Parathyroid hormone-related protein (PTHrP) and malignancy
2022PTHrP (parathyroid hormone related protein) is an important mediator of malignancy-related tumor progression and hypercalcemia that shares considerable homology and functionality with parathyroid hormone. In this chapter, we review what has been elucidated to date regarding PTHrP's role in malignancies.
Ami, Grunbaum, Richard, Kremer
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Parathyroid Hormone-Related Protein and Lung Injury
Chest, 20022002;122;1494-1495 Chest Randolph H. Hastings and Leonard J. Deftos Lung Injury Parathyroid Hormone-Related Protein and http://chestjournal.chestpubs.org/content/122/4/1494.full.html services can be found online on the World Wide Web at: The online version of this article, along with updated information and ISSN:0012-3692 ) http://chestjournal ...
Randolph H, Hastings, Leonard J, Deftos
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Parathyroid Hormone-Related Protein in Prostate Cancer
Critical Reviews in Eukaryotic Gene Expression, 2005Although originally discovered as the peptide responsible for humoral hypercalcemia of malignancy (HHM), parathyroid hormone-related protein (PTHrP) has been shown to play a major role in fetal development. In the adult, it is widely distributed in normal and various cancer tissues.
Farrokh, Asadi, Subhash, Kukreja
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Parathyroid Hormone-Related Protein: Roles in the Glomerulus
Nephron Experimental Nephrology, 1999Parathyroid hormone (PTH) and PTH-related protein (PTHrP) produce similar biological effects through the PTH/PTHrP receptor. Less is known about the physiological role of PTHrP which was first identified as the agent of the humoral hypercalcemia of malignancy.
R J, Bosch +3 more
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PARATHYROID HORMONE‐RELATED PROTEIN IN HYPERCALCAEMIA OF MALIGNANCY
Clinical Endocrinology, 1989Synthese des connaissances actuelles concernant une proteine hypercalcemiante, la PTHrP isolee chez les malades presentant une hypercalcemie paraneoplasique. Sont successivement envisages: son isolement, sa structure, ses proprietes biologiques, ses caracteres antigeniques et son gene de structure.
T J, Martin, L J, Suva
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The complexity of parathyroid hormone-related proteinsignalling
Cellular and Molecular Life Sciences (CMLS), 2004Our understanding of the mode of action of parathyroid hormone-related protein (PTHrP) has changed profoundly during the last decade. Most PTHrP activities are mediated by membrane receptors through autocrine/paracrine pathways. However, both endogenous and exogenous PTHrP also appear to have intracrine effects through translocation into the nucleus ...
E, Maioli, V, Fortino
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Parathyroid hormone-related protein and bone metastases
Cancer, 1997Parathyroid hormone-related protein (PTH-rP) was purified and cloned 10 years ago as a factor responsible for the hypercalcemia associated with malignancy. Clinical evidence supports another important role for PTH-rP in malignancy as a mediator of the bone destruction associated with osteolytic metastasis. Patients with PTH-rP positive breast carcinoma
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Actions of parathyroid hormone and parathyroid hormone-related protein.
Journal of endocrinological investigation, 1993By interacting with a structurally identical receptor, parathyroid hormone (PTH) and parathyroid hormone-related protein (PTHrP) display a common spectrum of action on the transport of mineral elements in bone and kidney. In vivo, PTH/PTHrP similarly reduce the renal tubular reabsorption of inorganic phosphate (Pi) and increase that of calcium.
R, Rizzoli +4 more
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Parathyroid Hormone-Related Protein
Reviews in Endocrine and Metabolic Disorders, 2000Lewis P. Rubin, John S. Torday
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Parathyroid hormone-related protein and lung biology
Respiratory Physiology & Neurobiology, 2004Parathyroid hormone-related protein (PTHrP) is expressed in normal and malignant lung and has roles in development, homeostasis, and pathophysiology of injury and cancer. Its effects in developing lung include regulation of branching morphogenesis and type II cell maturation.
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