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Parathyroid Hormone-Related Protein
Critical Reviews in Clinical Laboratory Sciences, 1995We review the current state of knowledge of the molecular properties and actions of parathyroid hormone-related protein (PTHrP) both in cancer patients and in normal physiology. PTHrP is a common product of squamous cancers and is the major mediator of the syndrome of humoral hypercalcemia of malignancy (HHM) by its actions through parathyroid hormone ...
Jane M. Moseley +2 more
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Parathyroid hormone related protein
Clinical Endocrinology, 1993In 1987, a second member of the parathyroid hormone (PTH) family, PTH-related protein (PTHrP), was identified and cloned (1). PTHrP is produced in many normal fetal (2–11) and adult (7,12–19) tissues, including several endocrine tissues, cartilage and bone, heart, vascular and other smooth muscle, skin, central nervous system, liver, kidney, and lung ...
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Parathyroid hormone-related protein and hypercalcemia
Cancer, 1997The discovery of parathyroid hormone-related protein (PTH-rP) arose from interest in the mechanisms by which certain cancers cause hypercalcemia without necessarily metastasizing to bone. The humoral hypercalcemia of malignancy (HHM) had for a long time been ascribed to inappropriate production of parathyroid hormone (PTH) by cancers.
W, Rankin, V, Grill, T J, Martin
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PARATHYROID HORMONE‐RELATED PROTEIN IN LOWER VERTEBRATES
Clinical and Experimental Pharmacology and Physiology, 1998SUMMARY1. Parathyroid hormone‐related protein (PTHrP) is an important mediator of humoral hypercalcaemia of malignancy in humans. Normal human subjects have very low levels of PTHrP in their circulation.2. Parathyroid hormone‐related protein has recently been demonstrated in high levels in the circulation and tissues of the sea bream and the dogfish ...
Danks, J. A. +5 more
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THE PARATHYROID HORMONE–RELATED PROTEIN
Endocrinology and Metabolism Clinics of North America, 2000Many physiologic roles of PTHrP are emerging. The protein functions locally in diverse tissues, often regulating the entry of cells into a differentiation pathway or acting as an epithelial signal in epithelial-mesenchymal interactions. To carry out these functions, PTHrP uses the receptor it shares with PTH or one of several PTHrP receptors that have ...
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Parathyroid Hormone and Parathyroid hormone-Related Protein
The Biomedical & Life Sciences Collection, 2001Publisher Summary This chapter focuses on current understanding of the physiology and mechanism of action of these polypeptides. Parathyroid hormone (PTH) and PTH-related protein (PTHrP) are major factors that regulate skeletal physiology and mineral homeostasis.
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Parathyroid hormone-related protein in healthy pregnant women
Calcified Tissue International, 1994The object of this study was to determine whether increased circulating levels of parathyroid hormone-related protein (PTH-rp) may explain the increased parathyroid hormone (PTH) bioactivity in pregnancy. In 41 healthy pregnant women (age 19-41 years), PTH-rp and corrected calcium levels were measured and compared with those of nonpregnant control ...
BERTELLONI S +4 more
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Primary hyperparathyroidism and parathyroid hormone-related protein
Current Opinion in Rheumatology, 1994Hypercalcemia is most commonly associated with primary hyperparathyroidism and malignancy due to parathyroid hormone-related protein (PTHrP). Primary hyperparathyroidism is characterized by excessive secretion of parathyroid hormone in association with hypercalcemia. The modern presentation of primary hyperparathyroidism is as an asymptomatic disorder.
M J, Horwitz, J P, Bilezikian
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Hypercalcaemia, Parathyroid Hormone-Related Protein and Malignancy
Clinical Oncology, 2001Hypercalcaemia is the most common serious metabolic complication of malignancy. Recent advances have significantly increased our understanding of the pathophysiology of hypercalcaemia of malignancy and revealed the importance of parathyroid hormone-related protein (PTHrP) in a wide range of physiological and pathological processes. This review examines
Bayne, M.C., Illidge, T.M.
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Parathyroid Hormone-Related Protein in Prostate Cancer
Critical Reviews in Eukaryotic Gene Expression, 2005Although originally discovered as the peptide responsible for humoral hypercalcemia of malignancy (HHM), parathyroid hormone-related protein (PTHrP) has been shown to play a major role in fetal development. In the adult, it is widely distributed in normal and various cancer tissues.
Farrokh, Asadi, Subhash, Kukreja
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