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The physiology of parathyroid hormone-related protein.
New England Journal of Medicine, 2000Parathyroid hormone–related protein was identified in the 1980s as a tumor product that had the ability to activate parathyroid hormone receptors and cause hypercalcemia.1 Parathyroid hormone–relat...
G. Strewler
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Parathyroid hormone-related protein (PTHrP) and malignancy.
Vitamins and hormones, 2022PTHrP (parathyroid hormone related protein) is an important mediator of malignancy-related tumor progression and hypercalcemia that shares considerable homology and functionality with parathyroid hormone. In this chapter, we review what has been elucidated to date regarding PTHrP's role in malignancies.
A. Grunbaum, R. Kremer
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Parathyroid hormone-related protein
Handbook of Hormones, 2021Parathyroid hormone-related protein (PTHrP) was the first hormone isolated as a hypercalcemic factor involved in the humoral hypercalcemia of malignancy. Human PTHrP encodes a 36-aa signal peptide and a 141-aa mature protein.
N. Suzuki
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Role of assays for parathyroid-hormone-related protein in investigation of hypercalcaemia.
Lancet, The, 1992W. A. Ratcliffe +3 more
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Parathyroid Hormone-Related Protein
Mayo Clinic Proceedings, 1990Parathyroid hormone-related protein (PTH-rP) is a protein with potent parathyroid hormone (PTH)-like activity which acts on PTH receptors in bone and kidney with generation of cAMP. It was initially purified from the BEN lung tumour cell line and breast and renal carcinomas associated with hypercalcaemia (Moseley et al. 1987; Burtis et al.
W. A. Ratcliffe, J. G. Ratcliffe
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