Results 291 to 300 of about 1,144,287 (339)

Physiology of Parathyroid Hormone

Endocrinology and Metabolism Clinics of North America, 2018
Parathyroid hormone (PTH) is the major secretory product of the parathyroid glands, and in hypocalcemic conditions, can enhance renal calcium reabsorption, increase active vitamin D production to increase intestinal calcium absorption, and mobilize calcium from bone by increasing turnover, mainly but not exclusively in cortical bone.
D. Goltzman
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Oxidation of parathyroid hormone

Clinica Chimica Acta, 2020
Parathyroid hormone (PTH) is the key hormone regulating calcium homeostasis and, as such, is an important diagnostic and prognostic marker. Although the measurement of PTH has greatly improved over the past few decades, oxidation status thereof is unaccounted for in currently used assays. PTH can be oxidized on methionine residues located at amino acid
Stan R. Ursem, Marc G. Vervloet, Renate T. de Jongh, Annemieke C. Heijboer   +3 more
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Physiology of the Calcium-Parathyroid Hormone-Vitamin D Axis.

Frontiers of Hormone Research, 2018
Classic endocrine feedback loops ensure the regulation of blood calcium. Calcium in the extracellular fluid (ECF) binds and activates the calcium sensing receptor (CaSR) on the parathyroid cells, leading to an increase in intracellular calcium.
D. Goltzman, M. Mannstadt, C. Marcocci
semanticscholar   +1 more source

Parathyroid hormone

2021
Parathyroid hormone is an essential regulator of extracellular calcium and phosphate. PTH enhances calcium reabsorption while inhibiting phosphate reabsorption in the kidneys, increases the synthesis of 1,25-dihydroxyvitamin D, which then increases gastrointestinal absorption of calcium, and increases bone resorption to increase calcium and phosphate ...
openaire   +2 more sources

BIOSYNTHESIS OF PARATHYROID HORMONE

Annals of the New York Academy of Sciences, 1977
Figure 11 summarizes our present concepts of the biosynthetic sequence for parathyroid hormone, deduced largely from observations in vitro. Many aspects of the presumed process whereby preproparathyroid hormone is converted via proparathyroid hormone to the hormone remain unclarified and require much further study, as is true for many other prehormones.
Joel F. Habener, Alexander Rich, Henry M. Kronenberg, John T. Potts   +3 more
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Cryo-EM structure of parathyroid hormone receptor type 1 in complex with a long-acting parathyroid hormone analog and G protein

, 2019
The parathyroid hormone receptor-1 (PTH1R) is a class B G protein–coupled receptor central to calcium homeostasis and a therapeutic target for osteoporosis and hypoparathyroidism. Here we report the cryo–electron microscopy structure of human PTH1R bound
Lihua Zhao, S. Ma, Ieva Sutkeviciute, D.-D. Shen, X. E. Zhou, P. Waal, Chuankui Li, Yanyong Kang, Lisa J. Clark, F. Jean-Alphonse, A. White, Dongyong Yang, A. Dai, X. Cai, Jianmin Chen, Chun Xing Li, Y. Jiang, Tomoyuki Watanabe, T. Gardella, K. Melcher, Ming-Wei Wang, J. Vilardaga, H. E. Xu, Yan Zhang   +23 more
semanticscholar   +1 more source

Parathyroid Hormone and Phosphaturia

Calcified Tissue Research, 1975
In 1911, Greenwald reported that urinary phosphate was significantly decreased in parathyroidectomized dogs (3). He was the first to suggest a link between the observed drop in phosphate excretion and the removal of the parathyroid glands. Sixty-four years later, the mechanism by which parathyroid hormone (PTH) enhances phosphaturia is still largely ...
R. J. Midgett, A. B. Borle, T. Uchikawa
openaire   +3 more sources

Parathyroid hormone and parathyroid hormone-related peptide, and their receptors

Biochemical and Biophysical Research Communications, 2005
Parathyroid hormone (PTH) has a central role in the regulation of serum calcium and phosphate, while parathyroid hormone-related peptide (PTHrP) has important developmental roles. Both peptides signal through the same receptor, the PTH/PTHrP receptor (a class B G-protein-coupled receptor).
Harald Jüppner, Thomas J. Gardella, Robert C. Gensure   +2 more
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Parathyroid Hormone Radioimmunoassay

Annals of Internal Medicine, 1979
Excerpt The study by Raisz and colleagues reported in this issue (1), although based on a small number of samples, illustrates both the assets and limitations of commercially available radioimmunoa...
Gino V. Segre, Joel F. Habener
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Parathyroid Hormone

Clinical Reviews in Bone and Mineral Metabolism, 2005
Parathyroid hormone (PTH) is the most recently approved agent for osteoposis treatment. It differs from other therapies that act by inhibiting bone resorption, because it stimulates bone formation. The resultant increases in bone mineral density are therefore greater than those associated with therapy with bisphosphonates (BPs), selective estrogen ...
Terry L. Seaton, Peter Koval
openaire   +2 more sources