Results 71 to 80 of about 2,189,457 (236)

The use of theory and research knowledge in child protection social work practice: A study of disorganised attachment and child protection assessment [PDF]

, 2015
This thesis seeks to examine how child protection social workers use theory and research knowledge related to disorganised attachment in the course of their practice with potentially abused or neglected children. In order to facilitate this understanding,
Wilkins, David
core  

Chemoproteomic Identification of AKT2 as a Paclitaxel‐Binding Protein via C─C Bond‐Linked Probe PTX‐4 in Paclitaxel‐Resistant Breast Cancer

Advanced Science, EarlyView.
ABSTRACT Breast cancer remains one of the most prevalent malignancies among women, and taxane‐based chemotherapies such as paclitaxel and docetaxel are central to standard treatment regimens. However, drug resistance in breast cancer limits therapeutic efficacy and contributes to recurrence and metastasis.
Kai Wang, Yuqing Yuan, Wei Shen, Xiuxiu Yang, Xiaokang Wu, Haihua Zhou, Yi Hu, Qing Zhu   +7 more
wiley   +1 more source

The specificity of mother's attachment to her child at an early age in the normal and severe dysontogenesis

Психология и Психотерапия Семьи, 2019
The study is focused on characteristics of attachment between a mother and her child of an early age. We have studied both families with typically developing children and families with children having signs of severe developmental disorders.
Tatiana Yakimova, PhD, Lyubov Metelkina
doaj   +1 more source

Parent–infant interaction in infant siblings at risk of autism [PDF]

, 2012
Recent models of the early emergence of autism spectrum disorder (ASD) propose an interaction between risk susceptibility and the infant's social environment, resulting in a progressively atypical developmental trajectory.
Johnson, Mark, Charman, Tony; id_orcid, Plummer, Fay, Plummer, Faye, Charman, Tony, Green, Jonathan; id_orcid, Wan, Ming Wai, The BASIS Team, The BASIS Team, ?, ?, Green, Jonathan, Wang, M, Wan, Ming Wai; id_orcid, Elsabbagh, Mayada, Johnson, Mark H., Charman, T., Green, J., Wan, M.W., Plummer, F.   +17 more
core   +1 more source

Integrative Omics Analysis Reveals the Regulation of Hypoxia Tolerance in Large Yellow Croaker (Larimichthys crocea) via the Lipoic Acid Synthase (lias) Gene

Advanced Science, EarlyView.
Lipoic acid synthase (lias) can regulate α‐KG levels through lipoylation, thereby negatively regulating HIF‐1α protein levels via PHD under hypoixa. The Hap2 allele of lias exhibits lower expression levels than Hap1, leading to the accumulation of more HIF‐1α protein and thereby enhancing hypoxia tolerance. ABSTRACT Hypoxia stress seriously affects the
Jie Ding, Songpeng Jia, Ran Meng, Xuelei Wang, Xiongfei Wu, Weiliang Shen, Yibo Zhang, Junquan Zhu   +7 more
wiley   +1 more source

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Exploring adverse parent-child relationships from the perspective of convicted child murderers: A South African qualitative study.

PLoS ONE, 2018
Child homicide is the most extreme form of violence against children. Within South Africa, children face the highest risk of homicide by parents/caregivers.
Bianca Dekel, Naeemah Abrahams, Michelle Andipatin   +2 more
doaj   +1 more source

The loss of a child: the long term impact upon the parent-child bond [PDF]

Research has been carried out from a psychological perspective, to examine the effects of bereavement in families when they have experienced the loss of a baby, child, teenager or young adult.
Merrington, Bill
core  

Super‐Multiplexed Label‐Free Raman Imaging Uncovers Novel Testicular Metabolic Couplings for Residual Body and Spermatogonial Differentiation

Advanced Science, EarlyView.
Super‐multiplexed Label‐free Raman Imaging (SLRI) enables 2D/3D metabolic mapping of intact Drosophila testes. Moving beyond descriptive morphology, it establishes a multidimensional tool for tissue metabolic remodeling, and offers a generalizable platform for complex tissue analysis, with implications extending to development and disease. ABSTRACT The
Jiaxin Li, Xia Chen, Yujuan Qi, Chen Qiao, Qiuru Huang, Dan Zhao, Weiyi Qian, Li Di, Yi Shi, Xiangqi Hu, Yueyue Shao, Kehan Wang, Zhiyu Tang‐Yang, Hanzhi Zang, Yuwen Du, Anran Dong, Jinxiong Feng, Jiayun Chen, Ying Zheng, Xiaofang Tan, Xiaoyu Zhao, Zhonghua Shi, Bo Zheng, Jun Yu   +23 more
wiley   +1 more source

ADHD Symptoms in Middle Childhood: The Role of Child Attachment and Maternal Emotional Availability in an Inpatient Clinical Sample

European Journal of Investigation in Health, Psychology and Education
Background: Child ADHD symptoms are highly prevalent in middle childhood, alongside impairment in social functioning. The parent–child relationship has been shown to play an important role; however, studies investigating specific facets of the parent ...
Michaela Augustin, Volker Mall, Maria Licata-Dandel   +2 more
doaj   +1 more source