Results 151 to 160 of about 2,189,507 (275)

1,2‐propanediol reformulation improves tribromoethanol safety and reveals pontine GABRA1 enrichment as a candidate mechanistic correlate of anesthesia

Animal Models and Experimental Medicine, EarlyView.
This study develops a reformulated tribromoethanol (TBE) anesthetic using 1,2‐propanediol as a solvent to overcome solvent‐related toxicity. The novel formulation demonstrates, cardiovascular stability, and survival in prolonged protocols. It provides potent, dose‐dependent anesthesia without strain or sex differences.
Xia Li, Yanming Chen, Xinyi Xiao, Guoheng Xu   +3 more
wiley   +1 more source

Cortical Thickness and White Matter Surface Morphology in Tourette Syndrome: A Cohort Study

Annals of Neurology, EarlyView.
Objective To examine cortical thickness and white matter surface morphology in a large sample of individuals with Tourette syndrome (TS) and neurotypical controls across the lifespan, and to assess associations with symptom severity, comorbidities, and medication use.
Sahar Delavari, Adam C. Frank, Ravi Bansal, Flora M. Vaccarino, Robert A. King, Paul Lombroso, Lawrence Scahill, James F. Leckman, Bradley S. Peterson   +8 more
wiley   +1 more source

Parenting interventions to support parent/child attachment and psychosocial adjustment in foster and adoptive parents and children: A systematic review. [PDF]

Campbell Syst Rev, 2022
Dalgaard NT, Filges T, Viinholt BCA, Pontoppidan M.   +3 more
europepmc   +1 more source

Attachment relationships and psychosomatic development of the child in families with a preterm baby. A study in DMM perspective.

, 2010
The aim of this study is to assess attachment and the role of Mother-Father-Child relationship in the family with preterm born child (< 1500 gr) from 3 months to 1 year corrected age compared with a control group of families with term-born children (>
BALDONI, FRANCO
core   +1 more source

Comparing the effectiveness of attachment-based play therapy and parent-child relationship therapy on the psychological well-being of children with separation anxiety disorder [PDF]

مجله علوم روانشناختی
Background: According to the World Health Organization, 20% of children and adolescents worldwide currently have mental health problems, but effective treatment coverage in this area is very low. Therefore, the application of evidence-based interventions
Mahsa Najmi, Reza Ghorban Jahromi, Esmail Sadipour, Mansoureh Karimzadeh   +3 more
doaj  

From Adversity to Materialistic Value Orientation: Parent-Child Attachment and Gender Differences in Chinese Adolescents. [PDF]

J Adolesc
Li P, Chen Q, Xin G, Xu J, Li N, Wang Y, Wang X.   +6 more
europepmc   +1 more source

The Longitudinal Association Between Parent-Child Attachment and Adolescent Depressive Symptoms: Moderation by Oxytocin Receptor Polymorphisms. [PDF]

Behav Sci (Basel)
Lin X, Ye W, He Y, Chen P, Mao J, Lai Y, Gu W, Luo Y, Li S, Nie Y.   +9 more
europepmc   +1 more source

A Portal‐Preorganized Cucurbit[7]uril‐Ruthenium Conjugate Enables Motif‐Selective Protein Sensing

Angewandte Chemie International Edition, EarlyView.
Reprogramming cucurbit[7]uril (CB7) recognition through portal engineering transforms an optically silent host into a motif‐selective photoluminescent receptor. The portal‐preorganized CB7‐Rubpy conjugate directly reports changes in aromatic motif accessibility, enabling optical sensing of protein misfolding and refolding.
Patrick Gruhs, Albert Kraft, Vahideh Mahram, Marco Neumaier, Papri Chakraborty, Emily Janz, Maria Vittoria Balli, Pierre Picchetti, Luca Prodi, Manfred Kappes, Frank Biedermann   +10 more
wiley   +1 more source

In Silico to In Cerebro—Development of the Orexin Receptor Antagonist “Photorexant” for Photomodulation In Vitro and in Mouse Brains

Angewandte Chemie International Edition, EarlyView.
Following a structure‐based design approach, photoswitchable derivatives of the FDA‐approved drug suvorexant were designed, docked, synthesized, and characterized pharmacologically at the orexin 1 and 2 receptors (OX1R and OX2R). Optimized “photorexant” showed up to an 11‐fold difference in IC50 between photoisomers, enabled dynamic and reversible ...
Marcus Angermann, Marie H. Deventer, Vicente Ledesma‐Martin, Nuno Martinho, Alix Flake, Silvia Mori, Angel Nuñez, Jaime Pignatelli, Rita C. Guedes, Christophe P. Stove, Michael Decker   +10 more
wiley   +1 more source

The role of editorial boards in shaping scholarly communication: A large‐scale mapping of their composition and structure

Journal of the Association for Information Science and Technology, EarlyView.
Abstract Editorial boards play a central role in shaping scholarly communication by influencing what research is published and how disciplinary boundaries are defined. Despite their importance, large‐scale, systematic evidence on their composition and structure remains limited.
Evangelina Becerra‐Rodero, José Luis Ortega   +1 more
wiley   +1 more source