Results 41 to 50 of about 565,118 (301)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Understanding the Role of Parent‒Child Relationships in Conscientiousness and Neuroticism Development among Chinese Middle School Students: A Cross-Lagged Model

open access: yesBehavioral Sciences, 2023
The parent‒child relationship is a crucial factor in promoting adolescent mental health. However, the current evidence on the relationship between parent‒child relationships and adolescent conscientiousness and neuroticism, as well as the directionality ...
Xiaojie Cao, Xinqiao Liu
doaj   +1 more source

Why human connection is the true metric of research success

open access: yesFEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan   +3 more
wiley   +1 more source

Parent–child attachment and mental health in young adolescents: a moderated mediation analysis

open access: yesFrontiers in Psychology, 2023
IntroductionThe parent–child attachment has a significant impact on adolescents’ mental health. However, the influence of psychological quality and coping styles on this connection remains unknown.
Rong Tan   +4 more
doaj   +1 more source

The long-term impact of parent death on adult children in midlife [PDF]

open access: yes, 2000
Plan BThis qualitative study examines the long-term impact of parent death on adult children in midlife. As such, all of the subjects have experienced the death(s) of one or both parents in adulthood.
Murauskas, Virginia M.
core  

Maternal Perceptions of Father Involvement, Co-parent Relationship Quality, Maternal Anxiety and Stress

open access: yes, 2023
Using a sample of 58 expecting mothers and 75 mothers this study examined maternal perceptions of father involvement and the association between perceived paternal involvement during pregnancy and the quality of the co-parent relationship using ...
Burdo, Victoria Corrine   +1 more
core  

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

open access: yesFEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya   +2 more
wiley   +1 more source

School absence of adolescents from single-parent families in Andalusia (Spain): exploring the mediating and moderating role of economic and social resources

open access: yesGenus
This study examines the relationship between growing up in single-parent families and school absence in Andalusia (Spain), considering differences according to adolescents’ social background.
Manuel Mejías-Leiva   +1 more
doaj   +1 more source

The effects of parent-child relationship, study stress, and mobile phone use on depressive symptoms among Chinese elementary school students: a moderated mediation model

open access: yesFrontiers in Psychiatry
IntroductionWith the rising prevalence of depressive symptoms among younger individuals, depressive symptoms in elementary school students have become a focal issue of concern in society.
Yiting Kong   +19 more
doaj   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

open access: yesFEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell   +8 more
wiley   +1 more source

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