Results 61 to 70 of about 1,605,888 (289)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Parental non-involvement strategy for handling sibling conflict on social avoidance in migrant children: Chain mediation of sibling conflict and parent-child conflict.

PLoS ONE
In the process of urbanization, the social adaptation of migrant children has become an important issue in their development. This study adopts family systems theory and ecological systems theory to examine the effects of parental non-involvement ...
Yuge Yue, Kaiwu Lu, Danping Ye
doaj   +1 more source

THE ROLE OF EMOTIONAL INTELLIGENCE IN MODERATING THE RELATIONSHIP BETWEEN PERCEIVED INTERPARENTAL CONFLICT AND MARITAL SATISFACTION AMONG MARRIED INDIVIDUALS

Jurnal Ilmu Keluarga dan Konsumen
The experience of growing up in a conflict-ridden family significantly influences individuals' views on marriage, emotion regulation, and the development of certain relationship patterns, which may either reflect or deviate from their parents' conflict ...
Rahelda Defanti, Lathifah Hanum, Cantyo A. Dannisworo, Fivi Nurwianti   +3 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Divorce or Continue Marriage for Child? An Important Question about Psychological Adjustment of Child [PDF]

Psikiyatride Güncel Yaklaşımlar
This study focused on finding answers about an important question that parents are recently asking psychological professionals. This question has become more relevant in the last couple of decades as there are increasing divorce rates in Turkey and the ...
Nilgun Ongider Gregory
doaj   +1 more source

Adolescent Beliefs about Antisocial Behavior: Mediators and Moderators of Links with Parental Monitoring and Attachment [PDF]

, 2012
The current study examined whether parental monitoring and attachment were related to adolescent beliefs about antisocial acts, with temperament, gender, and age considered as potential moderators. A total of 7135 adolescents, ages 14-18 years, completed
Spring, Mary, Kennedy, Richard, Volk, Anthony, Anthony Volk, Richard Kennedy, Marini, Zopito, Mary Spring, Dane, Andrew, Andrew Dane, Zopito Marini   +9 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Financial Stress, Family Conflict, and Youths’ Successful Transition to Adult Roles [PDF]

We analyze the effect of mothers’ and youths’ reports of family financial stress and conflict on youths’ transitions into adult roles. We find that mothers’ reports of financial stresses and borrowing constraints are associated with earlier transitions ...
Deborah A. Cobb-Clark, David C. Ribar
core   +2 more sources

Transcriptomes of parents identify parenting strategies and sexual conflict in a subsocial beetle [PDF]

, 2015
This work was funded by UK NERC grants to M.G.R. and A.J.M. an NERC studentship to D.J.P. the University of Georgia and a US NSF grant to A.J.M. and M.G.R.Parenting in the burying beetle Nicrophorus vespilloides is complex and, unusually, the sex and ...
Chris Cunningham, Darren J. Parker, Parker, Darren James, Craig A. Walling, Eileen M. Roy-zokan, Ritchie, Michael Gordon, Roy-Zokan, Eileen M., Stamper, Clare E., Head, Megan L., Parker, Darren, Megan L. Head, Walling, Craig A., Ritchie, Mike, Head, Megan, Clare E. Stamper, Moore, Allen J, Parker, Darren J., Elizabeth C. Mckinney, Ritchie, Michael G., McKinney, Elizabeth C., Cunningham, Christopher B., Michael G. Ritchie, Moore, Allen J., Christopher B. Cunningham, Allen J. Moore   +24 more
core   +1 more source