Results 71 to 80 of about 1,605,888 (289)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Parental Stress, and Parental Self-Efficacy as Determinants of Work-Family and Family-Work Conflict among Working Fathers

Journal of Research in Social Sciences
Present study examined the relationships among work-to-family conflict (WFC), family-to-work conflict (FWC), parental self-efficacy (PSE) and parental stress in full-time employed fathers.
Anila Mukhtar, Zufrah Taimuri, Maria Tabassum, Sitara Shahadat   +3 more
doaj   +3 more sources

Cognitive and emotional conflict control among children affected by parental HIV/AIDS in China

Frontiers in Psychiatry
BackgroundChildren affected by parental HIV/AIDS constitute a particularly vulnerable population, often facing heightened risks in psychosocial adaptation due to family disruption, social stigma, and resource deprivation.
Huihui Wang, Juan Liu, Danfeng Wen, Wan Zhao, Xiaoming Li, Junfeng Zhao   +5 more
doaj   +1 more source

Parent Conflict Resolution

, 2018
Parent–adolescent conflict is normative, and whether and how conflicts are resolved tend to be more important for adolescent adjustment than the actual occurrence of conflicts. On average, both parents' and adolescents' use of positive conflict resolution tends to increase, and negative conflict resolution tends to decrease, with age, although ...
openaire   +3 more sources

The Effects of Near and Actual Parental Divorce on Student Achievement and Misbehavior [PDF]

It is well-documented that children whose parents divorced experience worse outcomes than children from two-parent families. However, data and methodological limitations have made it difficult to know whether declines were evident prior to the divorce or
Mark L. Hoekstra
core  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Parental separation and children's education in a comparative perspective: Does the burden disappear when separation is more common?

Demographic Research, 2017
Background: Parental breakup has, on average, a net negative effect on children's education. However, it is unclear whether this negative effect changes when parental separation becomes more common.
Martin Kreidl, Martina Štípková, Barbora Hubatková   +2 more
doaj   +1 more source

Parental conflicts: influences on the development of children [PDF]

, 2009
Includes bibliographical ...
Thokala, Mary Rebecca
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Children’s Cognitive and Emotional Processes in Adult Versus Child-Related Inter-Parental Conflicts

Europe's Journal of Psychology, 2019
In the literature, little attention has been paid to the specific impact of child-related versus adult-related inter-parental conflicts on children’s intrapersonal processes and adjustment.
Elena Camisasca, Sarah Miragoli, Paola Di Blasio   +2 more
doaj   +1 more source