Results 101 to 110 of about 10,583,601 (308)
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Early Childhood Investments in Human Capital: Parental Resources and Preferences [PDF]
This paper investigates the way in which parental human capital investment in young co-resident children varies with their own consumption. It is motivated by rejection of parental altruism in recent research, the unexpectedly small effects of parental ...
Sonia Bhalotra
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The Intergenerational Effects of Parental Incarceration
The Economic JournalWe estimate the causal effects of parental incarceration on children’s short- and long-run outcomes using administrative data from Sweden. Our empirical strategy exploits exogenous variation in parental incarceration from the random assignment of criminal defendants to judges with different incarceration tendencies.
Hans Grönqvist +3 more
openaire +4 more sources
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Fathers' childcare and parental leave policies: Evidence from Western European Countries and Canada [PDF]
The study at hand pursues the following question: How are national parental leave arrangements related to fathers' participation in and time used for childcare?
Reich, Nora +2 more
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Peer-victimization and mental health problems in adolescents : are parental and school support protective? [PDF]
, 2010 The aim of this study was to investigate the frequency and effects of peer-victimization on mental health problems among adolescents. Parental and school support were assumed as protective factors that might interact with one another in acting as buffers
Rohrmann, Sonja +14 more
core +1 more source
Ecology and Evolution, 2018 Offspring quality decreases with parental age in many taxa, with offspring of older parents exhibiting reduced life span, reproductive capacity, and fitness, compared to offspring of younger parents. These “parental age effects,” whose consequences arise
Eric J. Ankutowicz, Robert A. Laird
doaj +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Parental Leave Policies and Parents' Employment and Leave-Taking [PDF]
Utilizing data from the June Current Population Survey (CPS) Fertility Supplement merged with data from other months of the CPS, we describe trends in parents' employment and leave-taking after birth of a newborn and analyze the extent to which these ...
Christopher Ruhm +2 more
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