Results 61 to 70 of about 834,940 (297)

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

open access: yesMolecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault   +12 more
wiley   +1 more source

Impact of parental leave system on the childbirth plan among working married women: a three-year follow-up study of the Korean longitudinal survey of women and families

open access: yesBMC Pregnancy and Childbirth
Background The Korean government seeks to balance work and family and alleviate low fertility by implementing a parental leave system. This study aimed to identify the impact of the parental leave system on childbirth among married working women in South
Yun Hwa Jung   +2 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

Employed or inactive? Cross-national differences in coding parental leave beneficiaries in European Labour Force Survey data

open access: yesSurvey Research Methods, 2013
In survey research the parental leave beneficiaries are usually coded as either employed or inactive. An exception is the European Labor Force Survey (EU-LFS), which includes parental leave among other forms of being employed but temporarily not ...
Malgorzata Mikucka, Marie Valentova
doaj   +1 more source

Parental Leave Quotas and Workplace Spillovers

open access: yes, 2023
Abstract This paper studies how parental leave quotas may foster a more gender-equal division of parental responsibilities by increasing fathers’ uptake of leave beyond the reserved amount. Specifically, the paper examines whether the introduction and expansion of parental leave quotas in Sweden generated spillover ...
openaire   +2 more sources

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

open access: yesFEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta   +7 more
wiley   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

open access: yesFEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão   +3 more
wiley   +1 more source

Consequences of Father’s Parental Leave Use: Evidence from Sweden

open access: yesFinnish Yearbook of Population Research, 2009
Fathers parental leave use is often assumed to affect gender equality both at home and in the labour market. In the home, fathers parental leave is expected to improve father-child contact later on in the childs life.
Ann-Zofie Duvander, Ann-Christin Jans
doaj  

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

open access: yesFEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard   +12 more
wiley   +1 more source

Parental Leave Policies and Parents' Employment and Leave-Taking [PDF]

open access: yes
Utilizing data from the June Current Population Survey (CPS) Fertility Supplement merged with data from other months of the CPS, we describe trends in parents' employment and leave-taking after birth of a newborn and analyze the extent to which these ...
Christopher Ruhm   +2 more
core  

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