Results 111 to 120 of about 136,527 (299)

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Building bridges? An evaluation of the costs and effectiveness of the separated parents information programme (PIP) [PDF]

, 2011
The Separated Parent Information Programme (PIP) is the first nationally available parent education programme for parents involved in litigation over contact and residence in England.
Bryson, Caroline, Coleman, Lester, Houlston, Catherine, Purdon, Susan, Reibstein, Janet, Smith, Leanne, Trinder, Liz   +6 more
core  

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

Positive, negative, and ambivalent: Indian parents’ attitudes to and mediation methods of children’s digital media use

Cogent Social Sciences
Children’s digital media use in India, particularly in urban family settings, has sharply increased over the years. As children continue to use digital media unprecedentedly, it is essential to know how the environments within which children grow ...
Sowparnika Pavan Kumar Attavar, Padma Rani   +1 more
doaj   +1 more source

Rhode Island Report on the Judiciary 2010 [PDF]

, 2010
On the pages that follow, you will find the Judiciary’s Annual Report for 2010. It is worth pointing out that throughout 2010, the courts progressed into a new era of leadership.

core   +1 more source

Rheumatologic Manifestations of Patients With Type B Insulin Resistance

Arthritis Care &Research, EarlyView.
Objective The objectives of this study were to identify laboratory and clinical features associated with type B insulin resistance (TBIR), a rare condition caused by autoantibodies that inhibit the insulin receptor, most frequently occurring in the setting of systemic lupus erythematosus (SLE), and to increase awareness of this rare, life‐threatening ...
S. Amara Ogbonnaya, Sandra G. Williams, Raphael A. Kirou, Marissa Lightbourne, Rebecca J. Brown   +4 more
wiley   +1 more source

Early Adolescents and Exposure to Risks Online: What Is the Role of Parental Mediation Styles?

Social Sciences
Studies indicate that early adolescents are exposed to several online risks. Furthermore, early adolescents with Special Educational Needs (SENs) often experience emotional, social, or family difficulties, which increase their vulnerability to online ...
Clara Cavallini, Simona Carla Silvia Caravita, Barbara Colombo   +2 more
doaj   +1 more source

EBSD Study of Creep‐Induced Lattice Misorientation in MgO‐Particle‐Reinforced Austenitic Steel Composites

Advanced Engineering Materials, EarlyView.
Creep experiments at 900°C on coarse‐grained steel‐ceramic composites containing recycled magnesia reveal that higher ceramic volume fractions significantly enhance the creep resistance. Detailed EBSD investigations identify subgrain formation in the steel matrix as the dominant deformation mechanism.
Moritz Müller, Amaya Compart, Mahnaz Mehdizadehlima, Serhii Yaroshevskyi, Christos G. Aneziris, Horst Biermann, Anja Weidner   +6 more
wiley   +1 more source

Parent Perspectives on Parent‐Mediated Intervention for Young Children With Down Syndrome

Journal of Applied Research in Intellectual Disabilities
ABSTRACTBackgroundParent‐mediated intervention (PMI) is a potentially scalable approach for tailored interventions in neurogenetic conditions like Down syndrome (DS). Because PMIs require ongoing parent engagement, they must be developed in alignment with the needs of intended users.
Walsh, Madison M., Van Deusen, Kaylyn, Pinks, Miranda E., Ceci, Benedetta, Hepburn, Susan, Riggs, Nathanial R., Pulina, Francesca, Marcolin, Chiara, Onnivello, Sara, Colaianni, Sara, Gray, Bethany, Daunhauer, Lisa A., Lanfranchi, Silvia, Fidler, Deborah J.   +13 more
openaire   +2 more sources

Parents’ opinions on parental mediation strategies used to instruct toddlers

Eesti Haridusteaduste Ajakiri. Estonian Journal of Education, 2015
Väikelaste kokkupuude puutetundlike ekraanidega algab juba imikueas ning esimese eluaasta jooksul saavad lastest regulaarsed meediatarbijad. Paraku ei ole ühest vastust, mil määral väikelapsed on suutelised puutetundliku ekraani vahendusel õppima ning kui palju nad vajavad selleks lapsevanema kaasabi.
Elyna Nevski, Kristi Vinter
openaire   +2 more sources