Results 71 to 80 of about 516,834 (295)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Online-delivered ‘Teaching Recovery Techniques’ for young people with PTSD symptoms who have experienced forced migration: a pilot study

Internet Interventions
Introduction: Although there is a high need for mental health support among individuals with experience of forced migration, there are barriers to accessing in-person interventions. Online delivery offers an alternative.
Georgina Warner, Sandra Gupta Löfving, Emma Geijer-Simpson   +2 more
doaj   +1 more source

Impact of a general practice based group parenting programme on the mental health of children and parents 12 months post intervention : quantitative and qualitative results from a controlled trial [PDF]

, 2004
Objective To test the effectiveness at one year of the Webster Stratton Parents and Children Series group parenting programme in a population sample of parents Design multicentre block randomised controlled trial Setting 3 urban General Practices in ...
Stewart-Brown, Sarah L., Patterson, Jacoby, Mockford, Carole, Barlow, Jane, Klimes, Ivana, Pyper, Cecilia   +5 more
core   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Implementation of the Infant-Toddler Checklist in Swedish child health services at 18 months: an observational study

BMJ Paediatrics Open
Background Communication and language disorders are common conditions that emerge early and negatively impact quality of life across the life course.
Anna Erica Fäldt, Anna Levin, Anton Dahlberg   +2 more
doaj   +1 more source

Arithmetic in the developing brain: A review of brain imaging studies

Developmental Cognitive Neuroscience, 2018
Brain imaging studies on academic achievement offer an exciting window on experience-dependent cortical plasticity, as they allow us to understand how developing brains change when children acquire culturally transmitted skills. This contribution focuses
Lien Peters, Bert De Smedt
doaj   +1 more source

Parenting stress and parent support among mothers with high and low education [PDF]

, 2015
Current theorising and evidence suggest that parenting stress might be greater among parents from both low and high socio-economic positions (SEP), compared to those from intermediate levels; due to material hardship among parents of low SEP, and to ...
Parkes, Alison, Sweeting, Helen, Wight, Daniel   +2 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Distant mothering, grandparenting, intergenerational coparenting relationship, and child adjustment: evidence from Chinese families with young left-behind children

Frontiers in Psychology
IntroductionIn China, it is a common practice for rural-to-urban migrant parents, due to working conditions, to leave their children with grandparents in their rural hometowns, and to raise their child from a distance (e.g., via mobile phone).
Ruwen Liang, Ruwen Liang, Karla Van Leeuwen   +2 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source