Results 71 to 80 of about 241,537 (301)

Distant mothering, grandparenting, intergenerational coparenting relationship, and child adjustment: evidence from Chinese families with young left-behind children

Frontiers in Psychology
IntroductionIn China, it is a common practice for rural-to-urban migrant parents, due to working conditions, to leave their children with grandparents in their rural hometowns, and to raise their child from a distance (e.g., via mobile phone).
Ruwen Liang, Ruwen Liang, Karla Van Leeuwen   +2 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Parenting programmes in South Africa: investigating design and evaluation practices [PDF]

, 2012
Includes abstract.Includes bibliographical references.Parenting programmes have been shown to have wide-ranging benefits, including the prevention of behavioural and emotional problems in children as well as child maltreatment.
Wessels, Inge
core   +1 more source

A DTI tractography study in pre-readers at risk for dyslexia

Developmental Cognitive Neuroscience, 2015
In adults and school-aged children, phonological aspects of reading seem to be sustained by left dorsal regions, while ventral regions seem to be involved in orthographic word recognition. Yet, given that the brain reorganises during reading acquisition,
Maaike Vandermosten, Jolijn Vanderauwera, Catherine Theys, Astrid De Vos, Sophie Vanvooren, Stefan Sunaert, Jan Wouters, Pol Ghesquière   +7 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Parenting interventions targeting early parenting difficulty: A scoping review

, 2022
Parent and child wellbeing are reciprocal. Attentive, responsive parenting, is contingent on parental wellbeing. Insights into mechanisms of early parenting interventions that seek to improve parent and child outcomes are needed.
Marie Hutchinson, Hutchinson, Marie, Hurley, John, Plummer, Karin, John Hurley, Bailey, Sherryn, Sherryn Bailey, Karin Plummer   +7 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

A Parenting Programme for Muslims

, 2018
Universal parenting intervention courses often fail to recruit and retain Muslim families. The practice of targeting specific populations in parenting programs is not well established.
Thomson, Kathryn, Butterworth, Ruth, Hussein, Hanan, Roche-Nagi, Kathleen   +3 more
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Preparing parents for parenthood: protocol for a randomized controlled trial of a preventative parenting intervention for expectant parents

BMC Pregnancy and Childbirth, 2018
Background Becoming the parent of a new baby comes with a range of challenges including difficulties with emotional adjustment, couple relationship issues and difficulty managing common infant behaviors, such as crying and sleep problems.
Mandy Mihelic, Alina Morawska, Ania Filus   +2 more
doaj   +1 more source