Results 81 to 90 of about 2,848,387 (303)

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

open access: yesMolecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault   +12 more
wiley   +1 more source

Parenting in the early years: effectiveness of parenting support programs for Indigenous families [PDF]

open access: yes, 2012
This resource sheet examines programs for Australian Indigenous families that effectively support parenting in the early years. This is not a systematic review of all programs; instead, it presents briefly on the evidence for parenting programs generally
Robyn Mildon, Melinda Polimeni
core  

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

open access: yesMolecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth   +17 more
wiley   +1 more source

A Study of Parenting Stress in Parents of Children with Disabilities

open access: yes, 2009
[[abstract]]Abstract The purpose of this research was to explore potential predictors of parenting stress in parents of children with disabilities. Further understanding of parenting stress in parents of children with disabilities may assist to provide ...
Change Yu Rung
core  

Parenting stress and psychological distress among mothers of children with autism in Johor Bahru and Hangzhou [PDF]

open access: yes, 2012
This study compared the parenting stress and psychological distress among mothers of children with autism in preschools and elementary schools from Johor Bahru and Hangzhou, as well as identified the significant factors associated with parenting stress ...
Yeo, Kee Jiar, Lu, Xi
core  

Prospective study of family adversity and maladaptive parenting in childhood and borderline personality disorder symptoms in a non-clinical population at 11 years [PDF]

open access: yes, 2012
Background Retrospective studies have consistently indicated an association between maladaptive parenting and borderline personality disorder (BPD). This requires corroboration with prospective, longitudinal designs.
Wolke, Dieter   +2 more
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

The impact of ostracism on parental burnout: The roles of parenting stress and perfectionism

open access: yesActa Psychologica
Objective: To explore the impact of ostracism on parental burnout as well as the roles of parenting stress and perfectionism. Methods: In this research, the ostracism experience scale, the parental burnout assessment, the parenting stress index short ...
Ran Tao   +3 more
doaj   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

open access: yesFEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu   +5 more
wiley   +1 more source

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