Results 61 to 70 of about 133,494 (302)
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
Interparental Conflict Styles and Parenting Behaviors: Associations With Overt and Relational Aggression Among Chinese Children [PDF]
, 2011 This study examined how interparental conflict styles related to Chinese children’s overt and relational aggression directly and indirectly through parenting behaviors. Mothers (n = 670) and fathers (n = 570) reported their overt and covert interparental
Li, Yan, Putallaz, Martha, Su, Yanjie
core +2 more sources
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Fathers’ parenting styles in Chinese families in urban Malaysia [PDF]
, 2012 The primary objectives of this study were to examine: 1) fathers’ parenting styles, and 2) the relationships between selected variables within the family ecosystems (e.g., father’s age, education, work hours, income, and psychological distress, child’s ...
Baharudin, Rozumah +2 more
core
The influence of social networking, video games and general computer usage on parent-child relations [PDF]
, 2015 The aim of this project was to find out how parents feel about controlling the media/technology use of their adolescent children and how it influences their parent/child relations.
Kroliczek, Ewelina
core +2 more sources
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Frontiers in PsychologyBackgroundDespite an increasing amount of research on the relationship between parenting styles and neurodevelopmental disorders, there has been minimal focus on how parenting styles impact children’s reading abilities.
Wanyi Wen +14 more
doaj +1 more source
Parenting and depressive symptoms among adolescents in four Caribbean societies
Child and Adolescent Psychiatry and Mental Health, 2012 Background The strategies that parents use to guide and discipline their children may influence their emotional health. Relatively little research has been conducted examining the association of parenting practices to depressive symptoms among Caribbean ...
Lipps Garth +6 more
doaj +1 more source
Parenting gifted and talented children: What are the key child behaviour and parenting issues? [PDF]
, 2008 Objective: The literature on gifted and talented children is limited. Little is known about the types and nature of difficulties experienced by gifted and talented children, and even less known about parenting issues related to parenting a gifted and ...
Bloom BS +12 more
core +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source