Results 81 to 90 of about 2,475,633 (258)

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Emerging Behavior Problems: Bidirectional Relations between Maternal and Paternal Parenting Styles with Infant Temperament

Developmental Psychology, 2019
The present study examined bidirectional effects between maternal and paternal parenting styles (authoritative, authoritarian, permissive) and infant temperament (negative affect, orienting/regulatory capacity, surgency) in a diverse sample of 201 ...
Shannon M. O. Wittig, Christina M. Rodriguez   +1 more
semanticscholar   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Effects of Parenting Styles on Self-Regulated Learning and Academic Stress in Spanish Adolescents

International Journal of Environmental Research and Public Health, 2019
Research has repeatedly highlighted the important influence of parental socialization styles on children’s psychosocial adjustment. However, previous studies about their effects on school adjustment have traditionally addressed a limited set of ...
Maria C. Fuentes, R. García-Ros, F. Pérez-Gónzalez, Dolores Sancerni   +3 more
semanticscholar   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

The impact of parenting style on malevolent creativity based on Chinese university students: a latent profile analysis

Frontiers in Psychology
IntroductionThis study investigated the association between parenting styles and malevolent creativity.MethodsIt used latent profile analysis to compare the differences in malevolent creativity between different combinations of parenting styles with an ...
Xingnan Cui, Xiang Zhang, Xiang Zhang, Hua Zhang   +3 more
doaj   +1 more source

Parenting Styles and Parent–Adolescent Relationships: The Mediating Roles of Behavioral Autonomy and Parental Authority

Frontiers in Psychology, 2018
The parent–adolescent relationship has been a classic research topic, and researchers have found that parenting styles (e.g., authoritative, authoritarian) are closely related to various qualities of parent-adolescent relationships (e.g., cohesion ...
Xinwen Bi, Yiqun Yang, Hai-Lei Li, Mei-Ping Wang, Wen-Xin Zhang, K. Deater-Deckard   +5 more
semanticscholar   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Relationship Between Parenting Styles and Personality in Older Spanish Adolescents

Behavioral Sciences
Adolescence is a critical period for identity formation and psychological adjustment, where parenting styles play a fundamental role in shaping socialization and emotional development. The present study analyzed the relationships of parenting styles with
Celia Cuadri, Joan García-Perales, Isabel Martínez, Feliciano Henriques Veiga   +3 more
doaj   +1 more source