Results 61 to 70 of about 15,881 (257)

Impact of Provincial Income Inequality on Parenting Styles in China during COVID-19

Behavioral Sciences
Research on Chinese parenting styles using representative samples is limited, particularly during COVID-19, with most studies focusing on individual factors while neglecting regional influences.
Rui Jin, Na Liu, Hao Zhou, Mingren Zhao
doaj   +1 more source

Parenting styles and Internet use [PDF]

Psychology & Marketing, 2017
AbstractThe Internet has become the most popular way for young people to communicate with one another. Recent data indicate that 95% of students have Internet access. This study examined the links between Internet use and the parenting styles that shape parent–child interactions.
openaire   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Exploring the Relationship Between Socio-economic Status and Parenting Styles: Educational Reflections from a Parental Perspective

Educational Process: International Journal
Background/purpose. This study aimed to identify the prevailing parenting styles in the Bekaa region in Lebanon from the parents’ perspective and to examine the relationship between these styles and parents’ educational level, income level, age, and ...
Shakiba Daoud, Wassim Abou-Yassin, Maha Krayem   +2 more
doaj   +1 more source

The Comparison of Healthy and Unhealthy Perfectionism and Type A Personality in The Perceived Parenting Styles in University Students

فصلنامه خانواده پژوهی, 2016
The purpose of the present research is to study healthy and unhealthy perfectionism as well as type A personality based on different parenting styles.
مریم جهان بخش, ابوالقاسم خوش کنش, محمود حیدری   +2 more
doaj  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Risky Play and Parenting Styles

Journal of Child and Family Studies, 2015
This study investigated the predictive power of parenting styles towards children and demographic characteristics on children’s risky play. 890 parents of 4–6 year-old children enrolled in public preschools and kindergartens in Denizli, Turkey completed the questionnaires related to demographic characteristics of themselves and their children, their ...
Cevher-Kalburan, Nilgün, İvrendi, Asiye   +1 more
openaire   +5 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source