Results 61 to 70 of about 2,475,633 (258)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Parenting styles, cyberaggression, and cybervictimization among adolescents

Computers in Human Behavior, 2019
Social concern about the negative effects of cyberbullying in children and adolescents’ psychosocial development is currently increasing. The importance of the family environment and factors in bullying has been highlighted, but little is known about the
David Moreno-Ruiz, Belén Martínez-Ferrer, Francisco García-Bacete   +2 more
semanticscholar   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

The relationship between impulsivity and non-suicidal self-injury in adolescents: the chain-mediated effects of parenting style and distress tolerance

Frontiers in Psychiatry
ObjectiveThe purpose of this study is to explore the related risk factors and protective factors of adolescent non suicidal self injury (NSSI).MethodsUtilizing the experience sampling method, we recruited 311 adolescents engaging in NSSI, all without ...
Hong Chen, Yuyu Gu, Congwen Yang, Hui Xiang   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Association between parenting styles and dyslexia in primary school students: the mediating role of home literacy environment

Frontiers in Psychology
BackgroundDespite an increasing amount of research on the relationship between parenting styles and neurodevelopmental disorders, there has been minimal focus on how parenting styles impact children’s reading abilities.
Wanyi Wen, Wanyi Wen, Xuanzhi Zhang, Xuanzhi Zhang, Kusheng Wu, Liwen Guan, Liwen Guan, Anyan Huang, Zhiya Liang, Xinle Yu, Xinle Yu, Qianfei Gu, Qianfei Gu, Yanhong Huang, Yanhong Huang   +14 more
doaj   +1 more source

Parenting Styles and Internalizing Symptoms in Adolescence: A Systematic Literature Review

International Journal of Environmental Research and Public Health, 2019
A growing body of recent research has identified associations between various parenting practices and styles and internalizing problems among adolescents.
A. Gorostiaga, J. Aliri, Nekane Balluerka, J. Lameirinhas   +3 more
semanticscholar   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Parenting and depressive symptoms among adolescents in four Caribbean societies

Child and Adolescent Psychiatry and Mental Health, 2012
Background The strategies that parents use to guide and discipline their children may influence their emotional health. Relatively little research has been conducted examining the association of parenting practices to depressive symptoms among Caribbean ...
Lipps Garth, Lowe Gillian A, Gibson Roger C, Halliday Sharon, Morris Amrie, Clarke Nelson, Wilson Rosemarie N   +6 more
doaj   +1 more source