Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
When a Parent Is Incarcerated: A Primer for Social Workers [PDF]
Offers guidance on meeting the needs of children of incarcerated parents, including reducing trauma, engaging incarcerated parents, re-entry planning, addressing domestic violence, and issues for parents in deportation proceedings.
Ken Borelli, Yali Lincroft
core
The Influence of Sugar-Sweetened Beverage Health Warning Labels on Parents' Choices [PDF]
US states have introduced bills requiring sugar-sweetened beverages (SSBs) to display health warning labels. This study examined how such labels may influence parents and which labels are most impactful.
core +1 more source
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Adolescents with Cancer and Occupational Deprivation in Hospital Settings: A Qualitative Study
Objective/Background: The aim of this article was to analyze the needs of hospitalized adolescents with cancer in relation to the performance of meaningful activities as well as to explore the possible scenarios of occupational deprivation in hospital ...
Pedro Moruno Miralles +2 more
doaj +1 more source
for African-American Youth [PDF]
with a Complementary Program for ...
Children Together, Informed Parents
core +1 more source
What is the effect of a decision aid in potentially vulnerable parents? Insights from the head CT choice randomized trial. [PDF]
ObjectiveTo test the hypotheses that use of the Head CT Choice decision aid would be similarly effective in all parent/patient dyads but parents with high (vs low) numeracy experience a greater increase in knowledge while those with low (vs high) health ...
Cohen, Daniel M +14 more
core +2 more sources
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Developing effective partnerships in reporting student achievement : making links between educative theory and schools reporting practices : a thesis presented as partial fulfilment of the requirements for the degree of Master of Educational Administration, Massey University, Albany [PDF]
This thesis examines how three participant schools reported the achievement of students to parents and the extent to which reporting practices reflected current educative theories and effective partnership.
Taylor, Kerry
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source

