Results 81 to 90 of about 4,635,505 (316)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

The newborn behavioural observations (NBO) system embedded in routine postpartum care in at-risk families in Iceland: a randomised controlled trial

BMC Pregnancy and Childbirth
Background The Newborn Behaviour Observation system (NBO) is a flexible relationship-based intervention designed to sensitise parents to their newborn’s capacities, to increase parental confidence and foster the bond between parent and infant. The aim of
Lisbeth Valla, Kari Slinning, Tore Wentzel-Larsen, Gun-Mette Røsand, Stefanía Birna Arnardóttir   +4 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Mothers' experiences of breastfeeding support and breastfeeding specialists' views on breastfeeding promotion in Finland – a qualitative interview study

Nordic Journal of Nursing Research
Promoting and supporting breastfeeding influences positively the health and well-being of both babies and mothers. However, many factors, such as maternal health, family and community support, cultural norms, societal aspects, educational level, and even
Katja Antila, Niina Pöyhönen, Saija Ohtonen-Jones, Marjorita Sormunen   +3 more
doaj   +1 more source

Foster Parent Training for the Delivery of Independent Living Skills [PDF]

, 2013
Master's Project (M.Ed.) University of Alaska Fairbanks, 2013Although training is made available to foster parents when they volunteer to share their homes with children in need, the required ten hours for single parents and fifteen hours for coupled ...
Alley, Kandy
core  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Child–parent interaction in relation to road safety education : Part 2 – main report [PDF]

, 2008
• Children and young people are particularly vulnerable road users. • Child pedestrian injury rates are poor compared with the rest of Europe. • The factors that impact on children’s road safety and their capability in traffic are numerous, multi-faceted
Ayrton, Rebecca, Cattan, Mima, Cross, Ruth, Green, Jackie, Newell, Caroline, Woodall, James, Woodward, Jenny   +6 more
core  

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Drawing Mama, a Practical Drawing Tutorial Book for Parents [PDF]

, 2019
Parents need to be closer to their children, especially when they are in early years. The process of the approach can be done in some creative way, one example is drawing together with children.
Azhar, D. A. (Devi ), Rahman, Y. (Yanuar )   +1 more
core  

Iraq and Afghanistan veterans’ experiences living with their parents after separation from the military [PDF]

, 2012
When military service members separate from the military, many return to their families of origin, living with their parents for a period of several weeks to years.
Ahem, R, Moos, M, Worthen, Miranda E
core   +2 more sources