Results 1 to 10 of about 16,297 (134)
Targeting the YAP-BST2 Axis Overcomes Intrinsic Anti-PD-1 Resistance in Metastatic Gastric Cancer. [PDF]
Adv Sci (Weinh)Concurrent YAP hyperactivation and Tp53 loss in Atp4b‐expressed parietal cell lineage drives gastric cancer initiation, multi‐organ metastasis, and intrinsic resistance to anti‐PD‐1 therapy. BST2 emerges as a direct YAP‐TEAD transcriptional target that engages PIRA2 on myeloid cells to establish an immunosuppressive microenvironment.
Zhang W +17 more
europepmc +2 more sources
Journal of Pharmacological Sciences, 2013 .: Atrophic gastritis caused by infection with Helicobacter pylori is characterized by parietal cell loss, which is a main risk factor for gastric cancer.
Koji Takeuchi +2 more
exaly +3 more sources
Autoimmune gastritis diverges from a shared corpus origin: molecular reconstruction of the adenocarcinoma axis and clinical anchoring of the neuroendocrine axis [PDF]
Frontiers in ImmunologyAutoimmune gastritis (AIG) arises from a T-cell–mediated immune attack on the gastric parietal cell and carries a dual neoplastic risk: gastric adenocarcinoma through spasmolytic polypeptide-expressing metaplasia (SPEM) and intestinal metaplasia, and ...
Jingna Tao +5 more
doaj +2 more sources
History and Pharmacological Mechanism of Gastric Acid-suppressive Drugs [PDF]
The Korean Journal of Helicobacter and Upper Gastrointestinal Research, 2023 Gastric acid-related disorders are commonly encountered in clinical practice. Acetylcholine, gastrin, and histamine are physiological agonists that stimulate acid secretion from parietal cells.
Dong Han Yeom, Yong Sung Kim
doaj +1 more source
Veterinary Sciences, 2022 To histologically evaluate the gastric compartments of Risso’s (Grampus griseus) and bottlenose dolphins (Tursiops truncatus) and provide suggestions for the diet of Risso’s dolphins in captivity, we examined 12 stomachs from both species.
Barbara Biancani +6 more
doaj +1 more source
Case Reports in Gastroenterology, 2021 Vonoprazan-associated gastric mucosal redness is rare, and its endoscopic and pathological features remain poorly described. We report 4 cases of vonoprazan-associated gastric mucosal redness, that is, 2 cases each in non-Helicobacter pylori-infected and
Kimitoshi Kubo +5 more
doaj +1 more source
Light and Electron Microscopic Studies on the Possible Protective Effect of Ginger on the Gastric Fundic Mucosa of Adult Male Albino Rats Treated with 5- Fluorouracil [PDF]
The Egyptian Journal of Histology, 2020 Introduction: 5-fluorouracil is a potent antimetabolite chemotherapeutic medication used for treatment of various malignancies . Using this agent result in toxic effect mainly in the lining of digestive tract.
Manar Bashandy, dalia noya
doaj +1 more source
Regression of Autoimmune Gastritis after Eradication of Helicobacter pylori
Case Reports in Gastroenterology, 2023 We report a case of autoimmune gastritis (AIG) in which gastric mucosal atrophy improved with Helicobacter pylori eradication. Based on endoscopic findings (advanced gastric atrophy with vascular visibility and diffuse redness in remnant oxyntic mucosa),
Tohru Kotera +3 more
doaj +1 more source
Genetic Ablation of the ClC-2 Cl- Channel Disrupts Mouse Gastric Parietal Cell Acid Secretion. [PDF]
PLoS ONE, 2015 The present studies were designed to examine the effects of ClC-2 ablation on cellular morphology, parietal cell abundance, H/K ATPase expression, parietal cell ultrastructure and acid secretion using WT and ClC-2-/- mouse stomachs.
Meghali P Nighot +6 more
doaj +1 more source
Brazilian Journal of Veterinary Pathology, 2021 We describe a case of hypertrophic gastropathy (Ménétrier’s like disease) with metastatic gastric adenocarcinoma in a seven-year-old intact female Labrador Retriever dog. The animal suddenly presented with emesis and died. Gross lesions included a marked
Thais Barroso Sarandy +3 more
doaj +1 more source