Results 41 to 50 of about 4,692,549 (177)

AL398, A Novel NSUN6 Inhibitor, Attenuates Epithelial‐Mesenchymal Transition and Metastasis in Endometrial Cancer by Abrogating m5C‐Dependent Stabilization of Snail mRNA

Advanced Science, EarlyView.
Proposed molecular mechanism: NSUN6 catalyzes m5C methylation on Snail mRNA to enhance its stability, leading to Snail upregulation and EMT promotion. The first‐in‐class inhibitor AL398 suppresses endometrial cancer metastasis by targeting the NSUN6‐m5C‐Snail. axis. ABSTRACT Endometrial cancer (EC) constitutes a leading gynecologic malignancy for which
Xiangzhuan Zhao, Linlin Yang, Huanxiang Chen, Chenfeng Guo, Hongshen Lu, Ying Zhu, Xuanzhi Wang, Yang Li, Ruike Zhang, Zichong Huang, Yifang Chen, Keyu Jin, Zeduo Xu, Lingxiu Meng, Longfeng Zhang, Yuanyuan Han, Yicong Yan, Qiaozhen Kang, Junhu Wan, Hongyang Liu   +19 more
wiley   +1 more source

Gastric Output of Pancreatic Secretory Trypsin-Inhibitor Is Increased by Misoprostol [PDF]

, 1991
Pancreatic secretory trypsin inhibitor (PSTI) is a potent protease inhibitor that also has growth promoting activity. It has recently been identified in the foveolar cells of the stomach, which secrete mucus.
Batten, J J, Calam, J, Freeman, T C, Vesey, D A, Batten, JJ, Baron, J H, Baron, JH, Playford, RJ, Fenn, GC, Freeman, TC, Beardshall, K, Playford, R J, Beardsall, K, Fenn, G C, Vesey, DA   +14 more
core   +1 more source

The critical role of BMP signaling in gastric epithelial cell differentiation revealed by organoids

Cell Regeneration
The efficient differentiation of adult gastric stem cells into specific epithelial cell types is crucial for gastric homeostasis. Although it is well appreciated that the niche plays a critical role in gastric epithelium cell differentiation, the ...
Fan Hong, Xiaodan Wang, Nanshan Zhong, Ze Zhang, Shibo Lin, Mengxian Zhang, Haonan Li, Yuan Liu, Yalong Wang, Lianzheng Zhao, Xiao Yang, Hongwen Zhou, Hui Liang, Ye-Guang Chen   +13 more
doaj   +1 more source

MAPA: A Semantic Network Framework for Functional Module Discovery and Interpretation in Multi‐Omics Data

Advanced Science, EarlyView.
MAPA transforms complex multi‐omics data into biologically coherent functional modules by integrating pathway information with molecular interaction networks. Retrieval‐augmented large language models then generate structured, literature‐informed interpretations.
Yifei Ge, Feifan Zhang, Yijiang Liu, Chao Jiang, Peng Gao, Nguan Soon Tan, Sai Zhang, Yuchen Shen, Qianyi Zhou, Xin Zhou, Xiao Wang, Fangqing Zhao, Chuchu Wang, Xiaotao Shen   +13 more
wiley   +1 more source

Inhibition of gastric H,K-ATPase activity and gastric epithelial cell IL-8 secretion by the pyrrolizine derivative ML 3000

BMC Gastroenterology, 2004
Background ML 3000 ([2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl]-acetic acid) is an inhibitor of both cyclooxygenase and 5-lipoxygenase in vitro, and shows promise as a novel non-steroidal anti-inflammatory drug (NSAID ...
Gupta Sandeep, Hammond Charles E, Goldenring James R, Smolka Adam J   +3 more
doaj   +1 more source

The mechanisms of gastric mucosal injury: focus on initial chief cell loss as a key target

Cell Death Discovery, 2023
Diffuse gastric mucosal injury is a chronic injury with altered cell differentiation, including spasmolytic polypeptide expression metaplasia (SPEM) and intestinal metaplasia (IM), which are considered precancerous lesions of gastric cancer (GC ...
Zilin Deng, Jiaxing Zhu, Zhiyuan Ma, Zhiqiang Yi, Biguang Tuo, Taolang Li, Xuemei Liu   +6 more
doaj   +1 more source

Oral Recombinant Human Collagen III Protects Gastric Mucosa via G‐Quadruplex‐Mediated Activation of the Pla2g4a‐Prostaglandin Axis

Advanced Science, EarlyView.
Orally administered recombinant human type III collagen protects the gastric mucosa from ethanol‐induced injury by coordinating redox homeostasis, epithelial barrier repair, and arachidonic acid–prostaglandin metabolism. Gastric digestion releases the pentapeptide GPAEF, which interacts with the Pla2g4a promoter G‐quadruplex in a structure‐dependent ...
Xinyue Lan, Qiu Dai, Yanhui Wang, Jiaxuan Gu, Chengyun Wang, Weicheng Xu, Xinru Gao, Jiageng Cheng, Wentao Geng, Xiaowen Wu, Haihang Li, Xiaoyun He, Shengwei Fu, Longjiao Zhu, Wentao Xu   +14 more
wiley   +1 more source

Critical influence of cytokines and immune cells in autoimmune gastritis

Autoimmunity, 2023
Gastric cancer (GC) is a type of the most common cancers. Autoimmune gastritis (AIG) and infection with Helicobacter pylori (HP) are the risk factors of triggering GC. With the emphasis on the treatment of HP, the incidence and prevalence of HP infection
Zepeng Zhang, Tongtong Zhu, Lei Zhang, Yanchao Xing, Zhiqiang Yan, Qingsong Li   +5 more
doaj   +1 more source

Allium sativum, a Natural and Pharmaco‐Remedial Panacea for Entero‐Gastritis, Antibiocidal/Dysbiogenesis, and Systemic Health Relevance

AgriFood: Journal of Agricultural Products for Food, EarlyView.
Natural Pharmaco‐remedial impacts of Allium sativum on Systemic health. ABSTRACT Arising from the emergence of diverse difficult‐to‐treat health cases, alterative‐therapeutic strategies have become a potential way forward for management/control. In traditional Chinese medicine (TCM), various plant materials have been sourced as alterative‐therapeutic ...
Patience O. Adomi, Bright E. Igere, Anthony J. Anozie, Oghenenyore A. Ohwokevwo   +3 more
wiley   +1 more source

Atrophic gastritis in a Shih-Tzu dog - case report

Semina: Ciências Agrárias, 2018
We report the case of a female Shih-Tzu dog with chronic vomiting and hematemesis not responsive to symptomatic treatment. Due to the non-specific clinical signs, the patient underwent endoscopy and biopsy of the gastric mucosa.
André Tobias Marques de Mattos, Nilva Maria Freres Mascarenhas, Mariana Itimura Camargo de Mattos, Carolina Grecco Grano Bordini, Taísa Schuartz Saragosa   +4 more
doaj   +1 more source