FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Publisher Correction: Prediction of all-cause mortality in Parkinson's disease with explainable artificial intelligence using administrative healthcare data. [PDF]
NPJ Parkinsons DisPark YH +4 more
europepmc +1 more source
Richmond National Battlefield Park
, 2018 This post is part of a series featuring behind-the-scenes dispatches from our Pohanka Interns on the front lines of history this summer as interpreters, archivists, and preservationists. See here for the introduction to the series.
Wilson, Albert
core
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Utility of the neutrophil-to-lymphocyte ratio extends to patients from East Asia. [PDF]
J Clin InvestYoo SK +6 more
europepmc +1 more source
POVERTY AND PARKS: INCOME RISK AND OTHER FACTORS AFFECTING PARK USE AND PERCEPTIONS IN POOR, RURAL SOUTH AFRICA [PDF]
Using panel data from a poor rural village adjacent to a game reserve in South Africa, this paper presents a simultaneous probit analysis of incursions into the park to gather resources and perceptions of the park.
Despins, Paula
core +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Cephalic Vein Aneurysm of the Wrist Adjacent to the Superficial Radial Nerve: A Case Report. [PDF]
Vasc Specialist IntYang HG, Park JK, Park YJ.
europepmc +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Research on the management of the system construction of National parks with China characteristics: Evidence from policy texts. [PDF]
PLoS OneLi JH, Yu HT, Chen WL, Wang Y.
europepmc +1 more source