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Parkin and Parkinsonʼs disease
Current Opinion in Neurology, 2001Parkin is the causative gene for an autosomal recessive form of Parkinson's disease. The gene was discovered in 1998. The parkin gene is a novel gene containing 12 exons spanning over 1.5 Mb and encodes a protein of 465 amino acids with a molecular mass of approximately 52,000 M(r). Various deletion mutations and point mutations have been discovered in
Y, Mizuno +4 more
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Parkinsonism & Related Disorders, 2009
The search for genetic mutations responsible for familial forms of Parkinson's disease (PD) has identified several genes and loci. Mutations in the parkin gene are linked to autosomal recessive juvenile parkinsonism. The genetic forms of PD are uncommon, but gene therapy targeting alpha-synuclein, parkin, or other pathways may be also applicable for ...
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The search for genetic mutations responsible for familial forms of Parkinson's disease (PD) has identified several genes and loci. Mutations in the parkin gene are linked to autosomal recessive juvenile parkinsonism. The genetic forms of PD are uncommon, but gene therapy targeting alpha-synuclein, parkin, or other pathways may be also applicable for ...
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NO Parkin in Parkinson's Disease
Science, 2004In their report “ S -nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function” (28 May, p. 1328; Science Express 22 Apr.), K. K. K. Chung et al . raise the intriguing possibility that nitric oxide (NO) may contribute to the degenerative process in Parkinson ...
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Parkin and mitophagy in cancer
Oncogene, 2016Mitophagy, the selective engulfment and clearance of mitochondria, is essential for the homeostasis of a healthy network of functioning mitochondria and prevents excessive production of cytotoxic reactive oxygen species from damaged mitochondria. The mitochondrially targeted PTEN-induced kinase-1 (PINK1) and the E3 ubiquitin ligase Parkin are well ...
J P, Bernardini, M, Lazarou, G, Dewson
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Science of Aging Knowledge Environment, 2005
Like a kid who misbehaves while her mother naps, a protein might run amok when cellular supervision wanes, triggering Parkinson's disease (PD). According to new work, quantities of the protein soar when another molecule that normally keeps it in check falters. The study suggests a new way to stanch the loss of brain cells in PD.
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Like a kid who misbehaves while her mother naps, a protein might run amok when cellular supervision wanes, triggering Parkinson's disease (PD). According to new work, quantities of the protein soar when another molecule that normally keeps it in check falters. The study suggests a new way to stanch the loss of brain cells in PD.
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Brain and nerve = Shinkei kenkyu no shinpo, 2008
Parkinson disease (PD) is the most common neurodegenerative disease, and the majority of PD cases involve the sporadic from of PD. Although the etiology of the sporadic form is unknown, mitochondrial dysfunction and oxidative stress are considered to play a prominent role in its pathogenesis.
Takao, Mitsui +2 more
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Parkinson disease (PD) is the most common neurodegenerative disease, and the majority of PD cases involve the sporadic from of PD. Although the etiology of the sporadic form is unknown, mitochondrial dysfunction and oxidative stress are considered to play a prominent role in its pathogenesis.
Takao, Mitsui +2 more
openaire +1 more source