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Arrestin‐3 binds parkin and enhances parkin‐dependent mitophagy
Journal of NeurochemistryAbstract Arrestins were discovered for their role in homologous desensitization of G‐protein‐coupled receptors (GPCRs). Later non‐visual arrestins were shown to regulate several signaling pathways. Some of these pathways require arrestin binding to GPCRs, the regulation of others is receptor independent.
Chen Zheng +4 more
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Parkin-associated Parkinson’s disease
Cell and Tissue Research, 2004Mutations in the PARK2 gene coding for parkin cause autosomal recessive juvenile parkinsonism (AR-JP), a familial form of Parkinson's disease (PD). Parkin functions as an E3 ubiquitin ligase, and loss of this ubiquitin ligase activity appears to be the mechanism underlying pathogenesis of AR-JP.
Rainer, von Coelln +2 more
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Parkin and Parkinsonʼs disease
Current Opinion in Neurology, 2001Parkin is the causative gene for an autosomal recessive form of Parkinson's disease. The gene was discovered in 1998. The parkin gene is a novel gene containing 12 exons spanning over 1.5 Mb and encodes a protein of 465 amino acids with a molecular mass of approximately 52,000 M(r). Various deletion mutations and point mutations have been discovered in
Y, Mizuno +4 more
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AbstractThe chapter outlines Frank Parkin’s work, who rediscovered Max Weber’s idea of open and closed social relationships and developed it into a sociological approach to address the limitations of the then-dominant Marxist class theory in analysing the structure of advanced capitalist societies.
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