Results 251 to 260 of about 59,114 (301)

TIGAR deficiency enhances cardiac resilience through epigenetic programming of Parkin expression. [PDF]

open access: yesJCI Insight
Tang Y   +8 more
europepmc   +1 more source

Advances in understanding mitophagy's role in lung injury. [PDF]

open access: yesChin J Traumatol
Du W   +6 more
europepmc   +1 more source

Parkin structure and function [PDF]

open access: yesFEBS Journal, 2015
Mutations in the parkin or PINK1 genes are the leading cause of the autosomal recessive form of Parkinson's disease. The gene products, the E3 ubiquitin ligase parkin and the serine/threonine kinase PINK1, are neuroprotective proteins, which act together in a mitochondrial quality control pathway.
Guennadi Kozlov, Kalle Gehring
exaly   +3 more sources
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No Parkin Zone: Mitophagy without Parkin

Trends in Cell Biology, 2018
Mitochondria are essential highly dynamic organelles that provide the necessary energy for a variety of different processes, such as survival, proliferation, and migration. In order to maintain an intact mitochondrial network, cells have developed quality control systems that allow the removal of damaged or superfluous mitochondria by selective ...
Elodie, Villa   +2 more
openaire   +2 more sources

Parkin and mitochondrial signalling

Cellular Signalling, 2023
Aging, toxic chemicals and changes to the cellular environment are sources of oxidative damage to mitochondria which contribute to neurodegenerative conditions including Parkinson's disease. To counteract this, cells have developed signalling mechanisms to identify and remove select proteins and unhealthy mitochondria to maintain homeostasis.
Elizabeth M, Connelly   +2 more
openaire   +2 more sources

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