Results 261 to 270 of about 9,561,546 (382)

Discriminating α-synuclein strains in Parkinson’s disease and multiple system atrophy

Nature, 2020
M. Shahnawaz, Abhisek Mukherjee, S. Pritzkow, Nicolas Mendez, Prakruti Rabadia, Xiangan Liu, Bo Hu, A. Schmeichel, W. Singer, Gang Wu, A. Tsai, Hamid Shirani, K. Nilsson, Phillip A. Low, C. Soto   +14 more
semanticscholar   +1 more source

Quantitative Profiling of Nanoscopic Protein Aggregates Reveals Specific Fingerprint of TDP‐43‐Positive Assemblies in Motor Neuron Disease

Advanced Science, EarlyView.
Single‐molecule fluorescence microscopy is combined with proteomic profiling to fingerprint the morphology and composition of TDP‐43 protein aggregates found in post‐mortem motor neuron disease brain tissues. Aggregate fingerprints can distinguish disease from control donors and detect unexpected TDP‐43 pathology in SOD1‐MND.
Dezerae Cox, Melanie Burke, Sara Milani, Matthew A White, Fergal M Waldron, Dorothea Böken, Evgeniia Lobanova, Jemeen Sreedharan, Jenna M Gregory, David Klenerman   +9 more
wiley   +1 more source

Metabolic Parkinson's disease. [PDF]

Front Aging Neurosci
Invernizzi F, Ciocca L, Contaldi E, Inverso D, Calandrella D, Mignone F, Barichella M, Isaias IU, Pezzoli G.   +8 more
europepmc   +1 more source

Action tremor in Parkinson's disease. [PDF]

, 1980
H. Teräväinen, D. B. Calne
openalex   +1 more source

Elevated Apolipoprotein E Expression in Hippocampal Microglia Drives Temporal Lobe Epilepsy Progression

Advanced Science, EarlyView.
In temporal lobe epilepsy, hippocampal APOE is markedly upregulated predominantly in microglia. APOE overexpression in microglia drives TLR4 and cGAS/STING‐dependent neuroinflammation, engages bidirectional crosstalk with neurons and astrocytes, increases neuronal excitability, and perturbs hippocampal lipid metabolism. These findings suggest that APOE‐
Jianwei Shi, Zesheng Li, Xin Sun, Yanfeng Yang, Yumin Luo, Ziang Song, Hengxin Dong, Lei Jin, Jing Xie, Yongzhi Shan, Guoguang Zhao   +10 more
wiley   +1 more source

Glymphatic dysfunction as a potential driver of cerebral iron deposition in Parkinson's disease. [PDF]

Brain Commun
Chen K, Ji Y, Zhang L, Zhang R, Li J, Lu L, Tang Y, Hu X, Wang F, Fang X.   +9 more
europepmc   +1 more source

Electrical stimulation of the subthalamic nucleus in advanced Parkinson's disease.

New England Journal of Medicine, 1998
P. Limousin, P. Krack, P. Pollak, A. Benazzouz, C. Ardouin, D. Hoffmann, A. Benabid   +6 more
semanticscholar   +1 more source

Identifying Tipping Points during Healthy Brain Aging through Single‐Nucleus Transcriptomic Analysis

Advanced Science, EarlyView.
This study applies single‐nucleus transcriptomics and systems dynamics to uncover nonlinear aging patterns in healthy human brains. By introducing dynamic network biomarker theory, the authors identify a critical tipping point at ages 56–60 during aging, and highlight glial instability as a key mediator.
Peiru Wu, Xuyu Zhao, Zixin Chen, Jingying Huang, Tengteng Dai, Jianxin Zhou, Luyao Xiao, Luonan Chen, Robert Chunhua Zhao, Jiao Wang   +9 more
wiley   +1 more source

Determining Medication Adherence in Patients Treated for Parkinson's Disease and Related Factors. [PDF]

Parkinsons Dis
Besharatpour M, Kavousi A, Salari M, Etemad K.   +3 more
europepmc   +1 more source

Visual fatigue and visual evoked potentials in multiple sclerosis, glaucoma, ocular hypertension and Parkinson's disease. [PDF]

, 1984
D. Regan, David R. Neima
openalex   +1 more source