Results 261 to 270 of about 322,606 (360)

Hydrogen‐Deuterium Exchange Mass Spectrometry for Molecular Glue Characterization

Advanced Science, EarlyView.
Molecular glues that stabilize protein–protein interactions are challenging to identify. Here, hydrogen‐deuterium exchange mass spectrometry can show and reveal gluing mechanisms that vary between protein binding partners. Abstract Molecular glues are powerful bioactive molecules that stabilize protein–protein interactions.
Danielle F. Kay, Hadeeqa G. Raza, Richard G. Doveston, Aneika C. Leney   +3 more
wiley   +1 more source

Can proton pump inhibitors increase the risk of sudden unexpected death in Parkinson's disease (SUDPAR)? [PDF]

Clinics (Sao Paulo)
Menezes-Rodrigues FS, Tallo FS, Caricati-Neto A, Finsterer J, Scorza CA, Scorza FA.   +5 more
europepmc   +1 more source

Reappraisal of Temporary Levodopa Withdrawal (Drug Holiday) in Parkinson's Disease

, 1985
Richard Mayeux, Yaakov Stern, Kevin P. Mulvey, Lucien Côté   +3 more
openalex   +2 more sources

Mixed Lineage Kinase Domain‐Like Protein (MLKL): From Mechanisms to Therapeutic Opportunities

Advanced Science, EarlyView.
The mixed lineage kinase domain‐like protein (MLKL) acts as the executioner in the necroptosis pathway, transitioning from an inactive to active state through phosphorylation, oligomerization, membrane recruitment, and membrane insertion, ultimately forming membrane hotpots.
Lijuan Xu, Chunlin Zhuang
wiley   +1 more source

Disability profiles and objective quantitative assessment in Parkinson's disease

, 1989
Bo Johnels, Páll Ingvarsson, M. Thorselius, Marjorie Valls, G. Steg   +4 more
openalex   +1 more source

The Effect of Immersion Technology on the Quality of Life in Older Adults: A Systematic Review

AGING MEDICINE, EarlyView.
Immersive technologies, especially virtual reality (VR), significantly improve the quality of life for older adults by enhancing physical health, cognitive function, and psychological well‐being. These technologies can be adapted to meet individual needs, making them an effective tool for addressing the challenges of aging.
Solmaz Sohrabei, Vahideh Zolfaghari, Seyed Jafar Ehsanzadeh   +2 more
wiley   +1 more source

Clinical and Functional Connectivity Markers in Prediction of Hallucinations in Parkinson's Disease. [PDF]

CNS Neurosci Ther
Li G, Jiang M, Chen X, Hu P, Liu J, Wang K.   +5 more
europepmc   +1 more source

A Versatile Near‐Infrared Fluorescent Probe for Fast Assessment of Lysosomal Status via a Large Multimodal Model

Aggregate, EarlyView.
Herein, we report a quinolinium‐based fluorescent probe, PA‐2, for near‐infrared super‐resolution imaging of lysosomal dynamics. Building on this, we next introduce a novel approach leveraging a large multimodal model (LMM), an advanced artificial intelligence tool, for automated image interpretation.
Rui Chen, Eugene Lee, Yuxin Wang, Aditya Yadav, Minling Zhong, Pragti, Yujie Sun, Jiajie Diao   +7 more
wiley   +1 more source

CSF Biomarker-Based Cognitive Trajectories in Parkinson's Disease-Subjective Cognitive Decline. [PDF]

Ann Clin Transl Neurol
Rodriguez-Antiguedad J, Puig-Davi A, Ruíz-Barrio I, Pagonabarraga J, Vázquez-Oliver A, Horta-Barba A, Kulisevsky J, Martínez-Horta S.   +7 more
europepmc   +1 more source

Supramolecular Probe for Monitoring Lysosomal Ferritinophagy to Facilitate the Early Diagnosis of Parkinson's Disease

Aggregate, EarlyView.
A supramolecular fluorescent probe, TPE‐4B/4Q[7], was designed to target lysosomes. The restriction of intramolecular rotation effect mediated by Q[7] enhances the fluorescence of TPE‐4B/4Q[7], enabling selective detection of Fe3+ with a detection limit of 1.23 × 10⁻⁶ M.
Shiqin Zhou, Bo Xiao, Jiamin Chen, Jinming Zhu, Xia Ran, Zuoji Liu, Chaozhong Li, Li Wang, Xinai Cui, Rong Li, Guangwei Feng, Jian Feng   +11 more
wiley   +1 more source