Results 251 to 260 of about 5,005,064 (282)

Adenosine monophosphate–activated protein kinase activation is associated with suppression of NLRP3 inflammasome–mediated neuroinflammation in a weight‐drop model of traumatic brain injury in Sprague–Dawley rats

Animal Models and Experimental Medicine, EarlyView.
This graphical abstract illustrates the study's schematic model. Adenosine monophosphate–activated protein kinase (AMPK) activators exhibited neuroprotection in the weight‐drop model of traumatic brain injury by improving cognition and regulating oxidative stress, microglial activation, and nucleotide‐binding oligomerization domain, leucine‐rich repeat,
Triveni Kodi, Paka Sravan Kumar, Krishnadas Nandakumar, Anoop Kishore   +3 more
wiley   +1 more source

Neurotransmitter‐Defined Degeneration Patterns in Sporadic and C9orf72‐Associated Amyotrophic Lateral Sclerosis: Predilection to GABAergic, Serotonergic, Opioid, Glutamatergic, Endocannabinoid, and Microglial Systems—Implications for Therapy Development

Annals of Neurology, EarlyView.
Objective Amyotrophic lateral sclerosis (ALS) has a markedly distinctive clinical and neuroradiological signature, with the preferential involvement of specific brain networks and the apparent sparing of others. The molecular underpinnings of the strikingly selective anatomical vulnerability have not been fully elucidated to date despite the potential ...
Marlene Tahedl, We Fong Siah, Jasmin Lope, Jennifer C. Hengeveld, Mark A. Doherty, Russell L. McLaughlin, Orla Hardiman, Ee Ling Tan, Alison Toomey, Jana Kleinerova, Peter Bede   +10 more
wiley   +1 more source

Digital profiling of dysarthria in late- and early-onset Parkinson's disease. [PDF]

J Parkinsons Dis
Escobar-Grisales D, Rozenfeld Olchik M, Arias-Vergara T, Brzoskowski Dos Santos V, Lara Bressanelli A, Mata I, Orozco-Arroyave JR, García AM.   +7 more
europepmc   +1 more source

Crowdsourcing and machine learning contests in Parkinson's disease research - when do they work? [PDF]

J Parkinsons Dis
Kirsch LC, Hausdorff JM, Dardov VJ.
europepmc   +1 more source

Quality and Readability of ChatGPT Performance on Parkinson's Disease. [PDF]

Mov Disord Clin Pract
Riccio G, Coppola R, Chiariello MR, Giglio A, De Rosa A.   +4 more
europepmc   +1 more source

The Incidence of Sensorineural Hearing Loss Diagnoses in People with and without Parkinson's Disease. [PDF]

Mov Disord Clin Pract
Hokkinen K, Dietz A, Lampela P, Hartikainen S, Tolppanen AM.   +4 more
europepmc   +1 more source

Individualized Bayesian Inference Identifies Novel Genetic Variants for Parkinson's Disease. [PDF]

Genet Epidemiol
Ren J, Soofi YJ, Rahman MA, Lu Q, Liu J.
europepmc   +1 more source

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Parkinson’s disease

2013
There have been a large number of basic research studies of noninvasive brain stimulation in Parkinson's disease. Initial work focused on measuring: (1) the excitability of corticospinal output with threshold and input-output measures, and (2) the effectiveness of intracortical γ-aminobutyric acid (GABA)ergic inhibitory systems using short-interval ...
John C, Rothwell, Mark J, Edwards
openaire   +5 more sources

Parkinson disease

Nature Reviews Disease Primers, 2017
Parkinson disease is the second-most common neurodegenerative disorder that affects 2-3% of the population ≥65 years of age. Neuronal loss in the substantia nigra, which causes striatal dopamine deficiency, and intracellular inclusions containing aggregates of α-synuclein are the neuropathological hallmarks of Parkinson disease.
Werner, Poewe, Klaus, Seppi, Caroline M, Tanner, Glenda M, Halliday, Patrik, Brundin, Jens, Volkmann, Anette-Eleonore, Schrag, Anthony E, Lang   +7 more
openaire   +2 more sources

Parkinson’s Disease

Medical Clinics of North America, 2019
The diagnosis of Parkinson disease (PD) is based on the presence of bradykinesia and either resting tremor or rigidity and there should be no features from the history or examination to suggest an alternative cause of parkinsonism. In addition to the motor manifestations of PD, there is a long list of nonmotor symptoms, several of which occur before ...
Stephen G, Reich, Joseph M, Savitt
openaire   +2 more sources