Results 21 to 30 of about 196,808 (340)
Upregulation of α-synuclein following immune activation: Possible trigger of Parkinson's disease
Neurobiology of Disease, 2022 Alpha-synuclein (α-syn) has been suggested to have many functions including, vesicle transport in neurons, transcriptional regulator, modulator of immune cell maturation and response, and a role as an antimicrobial peptide.
Alysa Kasen +5 more
doaj
Advances in cell transplantation therapy and gene therapy in Parkinson's disease
Chinese Journal of Contemporary Neurology and Neurosurgery, 2022 The role of cell transplantation therapy and gene therapy in the treatment of Parkinson's disease (PD) has attracted more and more attention. It has developed from laboratory research tools to clinical products for patients.
XU Bao⁃lei, CHAN Piu
doaj +1 more source
Methamphetamine and Parkinson's Disease [PDF]
Parkinson's Disease, 2013 Parkinson's disease (PD) is a neurodegenerative disorder predominantly affecting the elderly. The aetiology of the disease is not known, but age and environmental factors play an important role. Although more than a dozen gene mutations associated with familial forms of Parkinson's disease have been described, fewer than 10% of all cases can be ...
Rosario Moratalla +6 more
openaire +5 more sources
Musculoskeletal Pain in Parkinson's Disease
Frontiers in Neurology, 2022 BackgroundMusculoskeletal pain is commonly experienced in patients with Parkinson's disease (PD). Few studies have investigated the clinical characteristics and risk factors associated with musculoskeletal pain.ObjectivesTo investigate the distribution ...
Jun Li +20 more
doaj +1 more source
Regulation of vesicular trafficking by Parkinson's disease-associated genes
AIMS Molecular Science, 2015 The regulatory mechanisms that control intracellular vesicular trafficking play important roles in cellular function and viability. Neurons have specific vesicular trafficking systems for synaptic vesicle formation, release and recycling.
Tsuyoshi Inoshita, Yuzuru Imai
doaj +1 more source
Simulation Study and At Home Diagnostic Tool for Early Detection of Parkinsons Disease [PDF]
arXiv, 2021 Hypomimia is a condition in the early stages of the progression of Parkinsons disease that limits the movement of facial muscles, restricting the accurate depiction of facial expressions. Also known as facial masking, this condition is an early symptom of Parkinson's disease, a neurodegenerative disorder that affects movement. To date, no specific test
arxiv
Severe Constipation in Parkinson's Disease and in Parkinsonisms: Prevalence and Affecting Factors
Frontiers in Neurology, 2019 Background: constipation is one of the most common and disabling non-motor symptoms of Parkinson Disease (PD) and Parkinsonisms (PS). Few studies evaluate the difference of prevalence between PD and PS and the cause leading to a severe constipation in ...
Giuseppe Frazzitta +4 more
doaj +1 more source
Analysis, Identification and Prediction of Parkinson Disease Sub-Types and Progression through Machine Learning [PDF]
, 2023 This paper represents a groundbreaking advancement in Parkinson disease (PD) research by employing a novel machine learning framework to categorize PD into distinct subtypes and predict its progression. Utilizing a comprehensive dataset encompassing both clinical and neurological parameters, the research applies advanced supervised and unsupervised ...
arxiv +1 more source
Frontiers in Neurology, 2021 Objective: In a prospective study, we investigated the association between physical activity and various motor, non-motor outcomes, and quality of life in early Parkinson's disease (PD) participants in the PD Longitudinal Singapore Study.Background ...
Samuel Yong-Ern Ng +25 more
doaj +1 more source
Imaging in Parkinson's Disease [PDF]
Clinical Medicine, 2016 Parkinson's disease (PD) is a chronic neurodegenerative disease characterized by the loss of nigrostriatal dopaminergic neurons and aggregation of misfolded α-synuclein in Lewy bodies. The underlying mechanisms of neurodegeneration in PD are still unknown, and there are no disease-modifying treatments to slow the neurodegenerative processes.
Pagano, Gennaro +2 more
openaire +7 more sources