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Parkinson's disease dementia: a neural networks perspective. [PDF]
, 2015 In the long-term, with progression of the illness, Parkinson's disease dementia affects up to 90% of patients with Parkinson's disease. With increasing life expectancy in western countries, Parkinson's disease dementia is set to become even more ...
Foltynie, T, Gratwicke, J, Jahanshahi, M
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Stem Cell Reports, 2016 Heterozygous mutations in the glucocerebrosidase gene (GBA) represent the strongest common genetic risk factor for Parkinson's disease (PD), the second most common neurodegenerative disorder.
Hugo J.R. Fernandes +19 more
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Parkinson’s Disease and Autophagy [PDF]
Parkinson's Disease, 2012 It is generally accepted that a correlation between neurodegenerative disease and protein aggregation in the brain exists; however, a causal relationship has not been elucidated. In neurons, failure of autophagy may result in the accumulation of aggregate-prone proteins and subsequent neurodegeneration.
Ana María Sánchez-Pérez +5 more
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Frontiers in Neuroanatomy, 2015 Immunohistochemistry (IHC) is a valuable method for identifying discrete neurochemical molecules by the interaction of target antigens with validated antibodies tagged with a visible label (e.g., peroxidase).
Satoshi eGoto +6 more
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Parkinson's disease: autoimmunity and neuroinflammation [PDF]
, 2016 Parkinson's disease is a neurodegenerative disease that causes the death of dopaminergic neurons in the substantia nigra. The resulting dopamine deficiency in the basal ganglia leads to a movement disorder that is characterized by classical parkinsonian ...
CINIGLIO APPIANI, MARIO +9 more
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The heterogeneity of Parkinson’s disease
Journal of Neural Transmission, 2023 AbstractThe heterogeneity of Parkinson’s disease (PD), i.e. the various clinical phenotypes, pathological findings, genetic predispositions and probably also the various implicated pathophysiological pathways pose a major challenge for future research projects and therapeutic trail design.
Ullrich Wüllner +7 more
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Predicting motor, cognitive & functional impairment in Parkinson's
Annals of Clinical and Translational Neurology, 2019 Objective We recently demonstrated that 998 features derived from a simple 7‐minute smartphone test could distinguish between controls, people with Parkinson's and people with idiopathic Rapid Eye Movement sleep behavior disorder, with mean sensitivity ...
Christine Lo +11 more
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Putaminal mosaic visualized by tyrosine hydroxylase immunohistochemistry in the human neostriatum.
Frontiers in Neuroanatomy, 2016 Among the basal ganglia-thalamocortical circuits, the putamen plays a critical role in the ‘motor’ circuits that control voluntary movements and motor learning.
Ryoma eMorigaki, Satoshi eGoto
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Primary skin fibroblasts as a model of Parkinson's disease [PDF]
, 2012 Parkinson's disease is the second most frequent neurodegenerative disorder. While most cases occur sporadic mutations in a growing number of genes including Parkin (PARK2) and PINK1 (PARK6) have been associated with the disease.
A Grunewald +84 more
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Upregulation of α-synuclein following immune activation: Possible trigger of Parkinson's disease
Neurobiology of Disease, 2022 Alpha-synuclein (α-syn) has been suggested to have many functions including, vesicle transport in neurons, transcriptional regulator, modulator of immune cell maturation and response, and a role as an antimicrobial peptide.
Alysa Kasen +5 more
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