Results 41 to 50 of about 5,338,575 (282)

Mild Cognitive Impairment in Parkinson’s Disease: A Review of Current Concepts

Neurology Research International, 2013
Mild Cognitive Impairment in Parkinson’s Disease (PD-MCI) is common and may be associated with accelerated progression to dementia. Considering the importance of this emerging entity, new diagnostic criteria have recently been proposed. Early recognition
Natalie C. Palavra, Sharon L. Naismith, Simon J. G. Lewis   +2 more
doaj   +1 more source

Treatment of dystonia and tics

Clinical Parkinsonism & Related Disorders, 2020
Treatment of dystonia and tics continues to evolve. In dystonia, while oral agents such as benzodiazepines, baclofen and anticholinergics remain in use, botulinum toxin (BoNT) continues to be regarded as the treatment of choice for focal and segmental ...
Steven Bellows, Joseph Jankovic
doaj   +1 more source

Subjective Cognitive Concerns and Cognitive Trajectories in Parkinson's Disease: Biomarker Impact [PDF]

Ann Clin Transl Neurol
ABSTRACT Objective To examine the relationship of subjective cognitive concerns (SCC) with biomarkers of Alzheimer's disease (AD), neurodegeneration, and Parkinson's disease (PD) and domain‐specific cognitive trajectories among cognitively unimpaired persons with de novo PD. Method Cognitively unimpaired participants with SCC (n = 294) and without SCC (
Lopez F, Erani F, Bangen K, Coughlin D, Galasko D, Thomas K.   +5 more
europepmc   +2 more sources

Challenges in Parkinson's Disease [PDF]

, 2016
Parkinson's disease is a common neurological disease and affects 2% population of more than 65 years of age and 5% more than 85 years of age. Pathomechanism of this disease is still not fully understood.
La Cognata V, Cavalcanti F, Cavallaro S., D'AGATA, VELIA MARIA   +3 more
core   +1 more source

What contributes to depression in Parkinson's disease? [PDF]

, 2001
Background: Depression is a common problem in patients with Parkinson's disease, but its mechanism is poorly understood. It is thought that neurochemical changes contribute to its occurrence, but it is unclear why some patients develop depression and ...
A. Schrag, N. P. Quinn, M. Jahanshahi, Schrag, A., Quinn, N.P., Jahanshahi, M.   +5 more
core  

Stem Derived Dopamine Neurons Will They Replace DBS as the Leading Neurosurgical Treatment for Parkinson's Disease?

, 2021
The use of stem cell derived dopamine neurons for treating patients with Parkinson's disease has now evolved to the first in human clinical trials.
Barker, Roger A,, Björklund, Anders,, Frucht, Steven J,, Svendsen, Clive N,, Lund University.   +4 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Physical Activity Improves Anxiety and Apathy in Early Parkinson's Disease: A Longitudinal Follow-Up Study

Frontiers in Neurology, 2021
Objective: In a prospective study, we investigated the association between physical activity and various motor, non-motor outcomes, and quality of life in early Parkinson's disease (PD) participants in the PD Longitudinal Singapore Study.Background ...
Samuel Yong-Ern Ng, Samuel Yong-Ern Ng, Nicole Shuang-Yu Chia, Nicole Shuang-Yu Chia, Mirza Masoom Abbas, Mirza Masoom Abbas, Ehsan Seyed Saffari, Xinyi Choi, Xinyi Choi, Dede Liana Heng, Dede Liana Heng, Zheyu Xu, Zheyu Xu, Zheyu Xu, Kay-Yaw Tay, Kay-Yaw Tay, Kay-Yaw Tay, Wing-Lok Au, Wing-Lok Au, Wing-Lok Au, Eng-King Tan, Eng-King Tan, Eng-King Tan, Louis Chew-Seng Tan, Louis Chew-Seng Tan, Louis Chew-Seng Tan   +25 more
doaj   +1 more source

Quality of Life and Mild Cognitive Impairment in Early Parkinson's Disease: Does Subtype Matter? [PDF]

, 2014
We evaluated the association between mild cognitive impairment (MCI) subtypes and quality of life (QoL) in 219 newly diagnosed Parkinson's disease (PD) patients without dementia.
Lawson, Rachael A, Taylor, John-Paul, Barker, Roger A, Duncan, Gordon W, Yarnall, Alison J, Khoo, Tien K, Collerton, Daniel, Breen, David P, Burn, David J, Barker, Roger A,, Lund University.   +10 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source