Results 21 to 30 of about 5,005,064 (282)
Dopamine signaling negatively regulates striatal phosphorylation of Cdk5 at tyrosine 15 in mice.
Frontiers in Cellular Neuroscience, 2013 Striatal functions depend on the activity balance between the dopamine and glutamate neurotransmissions. Glutamate inputs activate cyclin-dependent kinase 5 (Cdk5), which inhibits postsynaptic dopamine signaling by phosphorylating DARPP-32 (dopamine- and
Yukio eYamamura +9 more
doaj +1 more source
Perceived changes to swallowing in people with Parkinson's disease [PDF]
, 2015 Aims: To describe the relationship between perceived swallowing difficulties in people with Parkinson's disease with disease-specific measures, carers' perceptions of swallowing problems and control participant responses.
Miller, Nick +5 more
core +1 more source
Primary skin fibroblasts as a model of Parkinson's disease [PDF]
, 2012 Parkinson's disease is the second most frequent neurodegenerative disorder. While most cases occur sporadic mutations in a growing number of genes including Parkin (PARK2) and PINK1 (PARK6) have been associated with the disease.
Morales-Gordo, B. +32 more
core +1 more source
Stem Cell Reports, 2016 Heterozygous mutations in the glucocerebrosidase gene (GBA) represent the strongest common genetic risk factor for Parkinson's disease (PD), the second most common neurodegenerative disorder.
Hugo J.R. Fernandes +19 more
doaj +1 more source
Aberrant functional connectivity within the basal ganglia of patients with Parkinson's disease
NeuroImage: Clinical, 2015 Resting state functional MRI (rs-fMRI) has been previously shown to be a promising tool for the assessment of early Parkinson's disease (PD). In order to assess whether changes within the basal ganglia network (BGN) are disease specific or relate to ...
Michal Rolinski +8 more
doaj +1 more source
Putaminal mosaic visualized by tyrosine hydroxylase immunohistochemistry in the human neostriatum.
Frontiers in Neuroanatomy, 2016 Among the basal ganglia-thalamocortical circuits, the putamen plays a critical role in the ‘motor’ circuits that control voluntary movements and motor learning.
Ryoma eMorigaki, Satoshi eGoto
doaj +1 more source
Predicting motor, cognitive & functional impairment in Parkinson's
Annals of Clinical and Translational Neurology, 2019 Objective We recently demonstrated that 998 features derived from a simple 7‐minute smartphone test could distinguish between controls, people with Parkinson's and people with idiopathic Rapid Eye Movement sleep behavior disorder, with mean sensitivity ...
Christine Lo +11 more
doaj +1 more source
Frontiers in Neuroanatomy, 2015 Immunohistochemistry (IHC) is a valuable method for identifying discrete neurochemical molecules by the interaction of target antigens with validated antibodies tagged with a visible label (e.g., peroxidase).
Satoshi eGoto +6 more
doaj +1 more source
Stability of MDS-UPDRS Motor Subtypes Over Three Years in Early Parkinson's Disease
Frontiers in Neurology, 2021 Background: Various classifications have been proposed to subtype Parkinson's disease (PD) based on their motor phenotypes. However, the stability of these subtypes has not been properly evaluated.Objective: The goal of this study was to understand the ...
Abhijeet K. Kohat +33 more
doaj +1 more source
Impact of Neu-botulinumtoxinA on the Severity and Quality of Life of Cervical Dystonia Patients
Tremor and Other Hyperkinetic Movements, 2016 Background: Cervical dystonia (CD) is a debilitating neurological disorder that may gravely affect a patient’s quality of life (QoL). Botulinum toxin treatment has been approved as a first-line treatment for this condition.
Priya Jagota +7 more
doaj +1 more source