Results 21 to 30 of about 5,338,575 (282)

Maternal Herpesviridae infection during pregnancy alters midbrain dopaminergic signatures in adult offspring

Neurobiology of Disease, 2022
Background: Motor symptoms of Parkinson's disease (PD) are apparent after a high proportion of dopamine neurons in the substantia nigra have degenerated.
Amanda R. Burmeister, Juozas Gordevicius, Emmanuel N. Paul, Christina Houck, Sonia George, Martha L. Escobar Galvis, Qiong Sha, Patrik Brundin, J. Andrew Pospisilik, Karen Racicot, Lena Brundin   +10 more
doaj   +1 more source

microRNA-7-5p and α-Synuclein SAA Predict Parkinson's Disease Phenoconversion. [PDF]

Ann Clin Transl Neurol
ABSTRACT Objective Corroborate blood neuron‐derived extracellular vesicle (NDEV) alpha‐synuclein (αSyn), the CSF αSyn seed amplification assay (αSyn‐SAA), and blood microRNA‐7‐5p (miR‐7‐5p) as markers for Parkinson's disease (PD) phenoconversion and determine if combining these markers would help select subjects who would be more likely to phenoconvert.
Zadegan S, Velammal P, Muthiah K, Jatty M, Adams C.   +4 more
europepmc   +2 more sources

Primary skin fibroblasts as a model of Parkinson's disease [PDF]

, 2012
Parkinson's disease is the second most frequent neurodegenerative disorder. While most cases occur sporadic mutations in a growing number of genes including Parkin (PARK2) and PINK1 (PARK6) have been associated with the disease.
Morales-Gordo, B., Jendrach, M., Heinz Reichmann, Brandt, Ulrich, Reichmann, H., Michael Klinkenberg, Jessica Drost, Morales-Gordo, Blas, Auburger, Georg, Blas Morales-Gordo, Vania Broccoli, Brandt, U., Marina Jendrach, Marcus, K., Klinkenberg, Michael, Auburger, G., Gispert, Suzana, Broccoli, Vania, Suzana Gispert, Marcus, Katrin, Ulrich Brandt, Jendrach, Marina, Wolfram S. Kunz, Klinkenberg, M., Drost, Jessica, Georg Auburger, Kunz, Wolfram S., Gispert, S., Kunz, W.S., Katrin Marcus, Droste, J.A.H., Broccoli, V., Reichmann, Heinz   +32 more
core   +1 more source

Progress Notes : a report from the Parkinson's Disease Center at Boston University Medical Center [PDF]

, 1996
News and updates from the Boston University Medical Center Parkinson's Disease ...
Parkinson's Disease Center at Boston University Medical Center
core   +1 more source

Lidocaine injections and neck corset wearing improve dropped head syndrome in Parkinson's disease and related disorders

Clinical Parkinsonism & Related Disorders, 2019
Background: Patients with Parkinson's disease and related disorders (PDRD) may exhibit dropped head syndrome (DHS), which does not yet have an effective treatment.
Yohei Mukai, Yoshihiko Furusawa, Yuko Morimoto, Yuka Hama, Tomoya Kawazoe, Yuji Saitoh, Takashi Sakamoto, Yuji Takahashi, Miho Murata   +8 more
doaj   +1 more source

Detection of emotions in Parkinson's disease using higher order spectral features from brain's electrical activity [PDF]

, 2014
Non-motor symptoms in Parkinson's disease (PD) involving cognition and emotion have been progressively receiving more attention in recent times. Electroencephalogram (EEG) signals, being an activity of central nervous system, can reflect the underlying ...
Mohamad, Khairiyah, Yuvaraj, R., Ibrahim, Norlinah Mohamed, Omar, Mohd Iqbal, Sundaraj, Kenneth, Murugappan, M., Palaniappan, Ramaswamy   +6 more
core   +1 more source

Adiponectin Paradox in Alzheimer's Disease; Relevance to Amyloidogenic Evolvability?

Frontiers in Endocrinology, 2020
Adiponectin (APN) is a multi-functional adipokine which sensitizes the insulin signals, stimulates mitochondria biogenesis, and suppresses inflammation.
Masaaki Waragai, Gilbert Ho, Yoshiki Takamatsu, Ryoko Wada, Shuei Sugama, Takato Takenouchi, Eliezer Masliah, Makoto Hashimoto   +7 more
doaj   +1 more source

Advances in cell transplantation therapy and gene therapy in Parkinson's disease

Chinese Journal of Contemporary Neurology and Neurosurgery, 2022
The role of cell transplantation therapy and gene therapy in the treatment of Parkinson's disease (PD) has attracted more and more attention. It has developed from laboratory research tools to clinical products for patients.
XU Bao⁃lei, CHAN Piu
doaj   +1 more source

Everyday walking with Parkinson's disease: understanding personal challenges and strategies [PDF]

, 2008
PURPOSE: This qualitative study was designed to explore the personal experience of everyday walking with Parkinson's disease (PD), the challenges and the strategies employed to compensate for difficulties, to help contextualise the scientific knowledge ...
Nieuwboer, Alice, Hetherington, V., Willems, A.M., van Wegen, E.E.H., Kwakkel, Gert, Rochester, Lynn, Jones, Diana, Birleson, A., Rochester, L., Jones, D.A., van Wegen, Erwin, Birleson, Angela, Nieuwboer, A., Hetherington, Victoria, Willems, Anne-Marie, Kwakkel, G.   +15 more
core   +1 more source

Discrepancies in symptom concerns and burden from the perspectives of parkinson's disease patients, caregivers, and physicians

Frontiers in Neurology
BackgroundDiscrepancies in symptom concerns and the perceived burden among individuals with Parkinson's disease (PD), their caregivers, and their physicians can hinder effective care.ObjectivesWe investigated differences in symptom recognition and ...
Shohei Okusa, Shohei Okusa, Shohei Okusa, Toshiki Tezuka, Toshiki Tezuka, Toshiki Tezuka, Tomonori Nukariya, Tomonori Nukariya, Tomonori Nukariya, Yoshihiro Nihei, Yoshihiro Nihei, Yoshihiro Nihei, Jin Nakahara, Jin Nakahara, Jin Nakahara, Morinobu Seki, Morinobu Seki, Morinobu Seki   +17 more
doaj   +1 more source