Results 11 to 20 of about 5,338,575 (282)

Perceived changes to swallowing in people with Parkinson's disease [PDF]

, 2015
Aims: To describe the relationship between perceived swallowing difficulties in people with Parkinson's disease with disease-specific measures, carers' perceptions of swallowing problems and control participant responses.
Miller, Nick, Jones, Diana, Emma Noble, Diana Jones, Noble, Emma, Nick Miller   +5 more
core   +1 more source

ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons

Stem Cell Reports, 2016
Heterozygous mutations in the glucocerebrosidase gene (GBA) represent the strongest common genetic risk factor for Parkinson's disease (PD), the second most common neurodegenerative disorder.
Hugo J.R. Fernandes, Elizabeth M. Hartfield, Helen C. Christian, Evangelia Emmanoulidou, Ying Zheng, Heather Booth, Helle Bogetofte, Charmaine Lang, Brent J. Ryan, S. Pablo Sardi, Jennifer Badger, Jane Vowles, Samuel Evetts, George K. Tofaris, Kostas Vekrellis, Kevin Talbot, Michele T. Hu, William James, Sally A. Cowley, Richard Wade-Martins   +19 more
doaj   +1 more source

Aberrant functional connectivity within the basal ganglia of patients with Parkinson's disease

NeuroImage: Clinical, 2015
Resting state functional MRI (rs-fMRI) has been previously shown to be a promising tool for the assessment of early Parkinson's disease (PD). In order to assess whether changes within the basal ganglia network (BGN) are disease specific or relate to ...
Michal Rolinski, Ludovica Griffanti, Konrad Szewczyk-Krolikowski, Ricarda A.L. Menke, Gordon K. Wilcock, Nicola Filippini, Giovanna Zamboni, Michele T.M. Hu, Clare E. Mackay   +8 more
doaj   +1 more source

Stability of MDS-UPDRS Motor Subtypes Over Three Years in Early Parkinson's Disease

Frontiers in Neurology, 2021
Background: Various classifications have been proposed to subtype Parkinson's disease (PD) based on their motor phenotypes. However, the stability of these subtypes has not been properly evaluated.Objective: The goal of this study was to understand the ...
Abhijeet K. Kohat, Abhijeet K. Kohat, Samuel Y. E. Ng, Samuel Y. E. Ng, Aidan S. Y. Wong, Aidan S. Y. Wong, Nicole S. Y. Chia, Nicole S. Y. Chia, Xinyi Choi, Xinyi Choi, Dede L. Heng, Dede L. Heng, Wei Li, Wei Li, Hwee-Lan Ng, Hwee-Lan Ng, Shu-Ting Chua, Shu-Ting Chua, Shermyn X. M. Neo, Shermyn X. M. Neo, Zheyu Xu, Zheyu Xu, Kay-Yaw Tay, Kay-Yaw Tay, Kay-Yaw Tay, Wing-Lok Au, Wing-Lok Au, Wing-Lok Au, Eng-King Tan, Eng-King Tan, Eng-King Tan, Louis C. S. Tan, Louis C. S. Tan, Louis C. S. Tan   +33 more
doaj   +1 more source

Development of a highly sensitive immunohistochemical method to detect neurochemical molecules in formalin-fixed and paraffin-embedded tissues from autopsied human brains

Frontiers in Neuroanatomy, 2015
Immunohistochemistry (IHC) is a valuable method for identifying discrete neurochemical molecules by the interaction of target antigens with validated antibodies tagged with a visible label (e.g., peroxidase).
Satoshi eGoto, Satoshi eGoto, Satoshi eGoto, Ryoma eMorigaki, Shinya eOkita, Shinji eNagahiro, Ryuji eKaji   +6 more
doaj   +1 more source

Predicting motor, cognitive & functional impairment in Parkinson's

Annals of Clinical and Translational Neurology, 2019
Objective We recently demonstrated that 998 features derived from a simple 7‐minute smartphone test could distinguish between controls, people with Parkinson's and people with idiopathic Rapid Eye Movement sleep behavior disorder, with mean sensitivity ...
Christine Lo, Siddharth Arora, Fahd Baig, Michael A. Lawton, Claire El Mouden, Thomas R. Barber, Claudio Ruffmann, Johannes C. Klein, Peter Brown, Yoav Ben‐Shlomo, Maarten deVos, Michele T. Hu   +11 more
doaj   +1 more source

Putaminal mosaic visualized by tyrosine hydroxylase immunohistochemistry in the human neostriatum.

Frontiers in Neuroanatomy, 2016
Among the basal ganglia-thalamocortical circuits, the putamen plays a critical role in the ‘motor’ circuits that control voluntary movements and motor learning.
Ryoma eMorigaki, Satoshi eGoto
doaj   +1 more source

Impact of Neu-botulinumtoxinA on the Severity and Quality of Life of Cervical Dystonia Patients

Tremor and Other Hyperkinetic Movements, 2016
Background: Cervical dystonia (CD) is a debilitating neurological disorder that may gravely affect a patient’s quality of life (QoL). Botulinum toxin treatment has been approved as a first-line treatment for this condition.
Priya Jagota, Lalita Kaewwilai, Nonglak Boonrod, Surat Singmaneesakulchai, Kamolwan Boonpang, Jirada Sringean, Onanong Jitkritsadakul, Sitthi Petchrutchatachart   +7 more
doaj   +1 more source

There Is No Parkinson Disease [PDF]

Archives of Neurology, 2008
The term Parkinson disease defines a specific clinical condition characterized by a typical history and characteristic signs. This review examines the historical evolution of the concept of Parkinson disease and how the misunderstanding of Parkinson disease may be hindering clinical research trials. It is proposed that this syndrome be called Parkinson
openaire   +2 more sources

Parkinson Disease [PDF]

Mayo Clinic Proceedings, 2016
Parkinson disease (PD) is a progressive neurodegenerative disease that affects one million people in the United States. This article reviews the etiology and pathophysiology of PD, risk factors, clinical manifestations, diagnostic criteria, and treatment of this common disease. Implications for home care clinicians are included.
Rachael A, Vaubel, Aditya, Raghunathan, Lori A, Erickson   +2 more
openaire   +4 more sources