Results 11 to 20 of about 295,503 (301)

Dopamine signaling negatively regulates striatal phosphorylation of Cdk5 at tyrosine 15 in mice.

Frontiers in Cellular Neuroscience, 2013
Striatal functions depend on the activity balance between the dopamine and glutamate neurotransmissions. Glutamate inputs activate cyclin-dependent kinase 5 (Cdk5), which inhibits postsynaptic dopamine signaling by phosphorylating DARPP-32 (dopamine- and
Yukio eYamamura, Ryoma eMorigaki, Jiro eKasahara, Hironori eYokoyama, Akie eTanabe, Shinya eOkita, Hidetaka eKoizumi, Shinji eNagahiro, Ryuji eKaji, Satoshi eGoto   +9 more
doaj   +1 more source

Stability of MDS-UPDRS Motor Subtypes Over Three Years in Early Parkinson's Disease

Frontiers in Neurology, 2021
Background: Various classifications have been proposed to subtype Parkinson's disease (PD) based on their motor phenotypes. However, the stability of these subtypes has not been properly evaluated.Objective: The goal of this study was to understand the ...
Abhijeet K. Kohat, Abhijeet K. Kohat, Samuel Y. E. Ng, Samuel Y. E. Ng, Aidan S. Y. Wong, Aidan S. Y. Wong, Nicole S. Y. Chia, Nicole S. Y. Chia, Xinyi Choi, Xinyi Choi, Dede L. Heng, Dede L. Heng, Wei Li, Wei Li, Hwee-Lan Ng, Hwee-Lan Ng, Shu-Ting Chua, Shu-Ting Chua, Shermyn X. M. Neo, Shermyn X. M. Neo, Zheyu Xu, Zheyu Xu, Kay-Yaw Tay, Kay-Yaw Tay, Kay-Yaw Tay, Wing-Lok Au, Wing-Lok Au, Wing-Lok Au, Eng-King Tan, Eng-King Tan, Eng-King Tan, Louis C. S. Tan, Louis C. S. Tan, Louis C. S. Tan   +33 more
doaj   +1 more source

How do I sound to me? Perceived changes in communication in Parkinson's disease [PDF]

, 2007
Objective: To examine self and carer perceived changes in communication associated with Parkinson's disease and relate these to speech intelligibility, gender, age and other disease measures.
Bosworth H., David J. Burn, Diana Jones, Emma Noble, Kelly G., Liesl Allcock, Nick Miller, Osgood C., Walshe M., Yorkston K.   +9 more
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What contributes to depression in Parkinson's disease? [PDF]

, 2001
Background: Depression is a common problem in patients with Parkinson's disease, but its mechanism is poorly understood. It is thought that neurochemical changes contribute to its occurrence, but it is unclear why some patients develop depression and ...
Jahanshahi, M., Quinn, N.P., Schrag, A.
core   +1 more source

ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons

Stem Cell Reports, 2016
Heterozygous mutations in the glucocerebrosidase gene (GBA) represent the strongest common genetic risk factor for Parkinson's disease (PD), the second most common neurodegenerative disorder.
Hugo J.R. Fernandes, Elizabeth M. Hartfield, Helen C. Christian, Evangelia Emmanoulidou, Ying Zheng, Heather Booth, Helle Bogetofte, Charmaine Lang, Brent J. Ryan, S. Pablo Sardi, Jennifer Badger, Jane Vowles, Samuel Evetts, George K. Tofaris, Kostas Vekrellis, Kevin Talbot, Michele T. Hu, William James, Sally A. Cowley, Richard Wade-Martins   +19 more
doaj   +1 more source

Parkinson's disease dementia: a neural networks perspective. [PDF]

, 2015
In the long-term, with progression of the illness, Parkinson's disease dementia affects up to 90% of patients with Parkinson's disease. With increasing life expectancy in western countries, Parkinson's disease dementia is set to become even more ...
Foltynie, T, Gratwicke, J, Jahanshahi, M
core   +1 more source

Aberrant functional connectivity within the basal ganglia of patients with Parkinson's disease

NeuroImage: Clinical, 2015
Resting state functional MRI (rs-fMRI) has been previously shown to be a promising tool for the assessment of early Parkinson's disease (PD). In order to assess whether changes within the basal ganglia network (BGN) are disease specific or relate to ...
Michal Rolinski, Ludovica Griffanti, Konrad Szewczyk-Krolikowski, Ricarda A.L. Menke, Gordon K. Wilcock, Nicola Filippini, Giovanna Zamboni, Michele T.M. Hu, Clare E. Mackay   +8 more
doaj   +1 more source

Development of a highly sensitive immunohistochemical method to detect neurochemical molecules in formalin-fixed and paraffin-embedded tissues from autopsied human brains

Frontiers in Neuroanatomy, 2015
Immunohistochemistry (IHC) is a valuable method for identifying discrete neurochemical molecules by the interaction of target antigens with validated antibodies tagged with a visible label (e.g., peroxidase).
Satoshi eGoto, Satoshi eGoto, Satoshi eGoto, Ryoma eMorigaki, Shinya eOkita, Shinji eNagahiro, Ryuji eKaji   +6 more
doaj   +1 more source

Abnormal temporal coupling of tactile perception and motor action in Parkinson's disease [PDF]

, 2017
Evidence shows altered somatosensory temporal discrimination threshold (STDT) in Parkinson's disease in comparison to normal subjects. In healthy subjects, movement execution modulates STDT values through mechanisms of sensory gating.
Baione, Viola, Battista, Emanuele, Belvisi, Daniele, Berardelli, Alfredo, Conte, Antonella, Cortese, FRANCESCA NATALIA, Fabbrini, Giovanni, Tartaglia, Matteo, Zhu, Xiao Y.   +8 more
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Predicting motor, cognitive & functional impairment in Parkinson's

Annals of Clinical and Translational Neurology, 2019
Objective We recently demonstrated that 998 features derived from a simple 7‐minute smartphone test could distinguish between controls, people with Parkinson's and people with idiopathic Rapid Eye Movement sleep behavior disorder, with mean sensitivity ...
Christine Lo, Siddharth Arora, Fahd Baig, Michael A. Lawton, Claire El Mouden, Thomas R. Barber, Claudio Ruffmann, Johannes C. Klein, Peter Brown, Yoav Ben‐Shlomo, Maarten deVos, Michele T. Hu   +11 more
doaj   +1 more source