Results 61 to 70 of about 214,205 (284)

Adiponectin paradox as a therapeutic target of the cancer evolvability in aging

Neoplasia: An International Journal for Oncology Research, 2021
Recent study suggests that protofibril-formation of amyloidogenic proteins (APs) might be involved in evolvability, an epigenetic inheritance of multiple stresses, in various biological systems.
Yoshiki Takamatsu, Gilbert Ho, Ryoko Wada, Satoshi Inoue, Makoto Hashimoto   +4 more
doaj   +1 more source

Are Stem Cell-Based Therapies for Parkinson's Disease Ready for the Clinic in 2016? [Elektronisk resurs]

, 2016
Recent news of an impending clinical cell transplantation trial in Parkinson's disease using parthenogenetic stem cells as a source of donor tissue have raised hopes in the patient community and sparked discussion in the research community.
Brundin, Patrik,, Barker, Roger A,, Björklund, Anders,, Parmar, Malin,, Kirkeby, Agnete,, Lund University., Thompson, Lachlan,   +6 more
core   +1 more source

Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler, Vivian Maas, Arian Taheri Amin, Jennifer Faber, Tamara Schaprian, Katharina Hill, Matthis Synofzik, Lisa H. Graf, Heike Jacobi, Manuela Lima, Ana F. Ferreira, Bart P. van de Warrenburg, Ilse H. J. Willemse, Dagmar Timmann, Andreas Thieme, Paola Giunti, Hector Garcia‐Moreno, Magda M. Santana, Jeannette Hübener‐Schmid, Elin H. Davies, Thomas Klockgether   +20 more
wiley   +1 more source

Region-specific deficits in dopamine, but not norepinephrine, signaling in a novel A30P α-synuclein BAC transgenic mouse

Neurobiology of Disease, 2014
Parkinson's disease (PD) is a neurodegenerative disorder classically characterized by the death of dopamine (DA) neurons in the substantia nigra pars compacta and by intracellular Lewy bodies composed largely of α-synuclein.
Tonya N. Taylor, Dawid Potgieter, Sabina Anwar, Steven L. Senior, Stephanie Janezic, Sarah Threlfell, Brent Ryan, Laura Parkkinen, Thierry Deltheil, Milena Cioroch, Achilleas Livieratos, Peter L. Oliver, Katie A. Jennings, Kay E. Davies, Olaf Ansorge, David M. Bannerman, Stephanie J. Cragg, Richard Wade-Martins   +17 more
doaj   +1 more source

Population-based studies on the epidemiology of migraine and Parkinson's disease [PDF]

, 2007
With epidemiologic analyses the effect of certain exposures on diseases can be studied in large population samples. Pharmacoepidemiology is a speciality which focuses on beneficial or harmful drug effects on the development of diseases.
Becker, Claudia
core   +1 more source

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source

Distribution and impact on quality of life of the pain modalities assessed by the King's Parkinson's disease pain scale

, 2017
In Parkinson's disease, pain is a prevalent and complex symptom of diverse origin. King's Parkinson's disease pain scale, assesses different pain syndromes, thus allowing exploration of its differential prevalence and influence on the health-related ...
Rizos, Alexandra,, Carmen Rodriguez-Blazquez, Martinez-Martin, Pablo, Rizos, Alexandra, Chaudhuri, Kallol Ray, Lauren Perkins, Manuel Rojo-Abuin, Jose, Alexandra Rizos, Jose Manuel Rojo-Abuin, Perkins, Lauren, Kallol Ray Chaudhuri, Anna Sauerbier, Manuel Rojo-Abuin, Jose,, Odin, Per, Rodriguez-Blazquez, Carmen, Sauerbier, Anna, Perkins, Lauren,, Antonini, Angelo, Antonini, Angelo,, Sauerbier, Anna,, Pablo Martinez-Martin, Odin, Per,, Martinez-Martin, Pablo,, Claudia Trenkwalder, null null, Per Odin, Trenkwalder, Claudia, Lund University., Angelo Antonini, Trenkwalder, Claudia,   +29 more
core   +1 more source

Brainstem and Cerebellar Volume Loss and Associated Clinical Features in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Progressive Supranuclear Palsy (PSP) is a neurodegenerative ‘tauopathy’ with predominating pathology in the basal ganglia and midbrain. Caudal tau spread frequently implicates the cerebellum; however, the pattern of atrophy remains equivocal.
Chloe Spiegel, Timothy P. Siejka, Cassandra Marotta, Josh J. Y. Lee, Kelly Bertram, Terence J. O'Brien, Meng Law, Lucy Vivash, Ian H. Harding   +8 more
wiley   +1 more source

Parkinson's Disease

, 2022
Parkinson’s disease is a common progressive neurodegenerative disease of the dopaminergic neurons within the substantia nigra pars compacta resulting in an altered motor movement.
Kakish, Diala Ra'Ed Kamal
core  

Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi, Caroline Gochanour, Seung Ho Choi, Hyunkeun Cho, Chelsea Caspell‐Garcia, Christopher Coffey, Michael Brumm, David‐Erick Lafontant, Yuge Xiao, Thomas Tropea, John Seibyl, Caroline Tanner, Charles S. Venuto, Karl Kieburtz, Lana M. Chahine, Kathleen L. Poston, Andrew Siderowf, Kenneth Marek, Tanya Simuni, The Parkinson's Progression Markers Initiative   +19 more
wiley   +1 more source