Results 71 to 80 of about 5,005,064 (282)

Relationship Between Neurologic Symptoms and Signs and FMR1 Genotype in Premutation Carriers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Fragile X‐associated Tremor/Ataxia Syndrome (FXTAS) is the most severe late‐onset condition caused by a premutation in the FMR1 gene, characterized by expanded CGG triplet repeats of 55–200. Clinical presentations of FXTAS, including gait ataxia, kinetic tremor, cognitive decline, and rare Parkinsonism, are linked to ...
Flora Tassone, Freddy Chafota, Miguel E. Rentería, Randi J. Hagerman, Ellery Santos, Anna Atkinson, Nicholas G. Martin, Elsdon Storey, Danuta Z. Loesch   +8 more
wiley   +1 more source

The impact of a parkinsonian lesion on dynamic striatal dopamine transmission depends on nicotinic receptor activation

Neurobiology of Disease, 2015
Dopamine function is disturbed in Parkinson's disease (PD), but whether and how release of dopamine from surviving neurons is altered has long been debated.
Katie A. Jennings, Nicola J. Platt, Stephanie J. Cragg   +2 more
doaj   +1 more source

GAD65 Antibody ELISA With Extended Reportable Range: Validation and Guidance for Neurological Practice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To (1) validate GAD65‐ELISA detection and quantification for type 1 diabetes mellitus and autoimmune neurological diagnoses, (2) correlate ELISA results (reference range < 5 IU/mL) with established radioimmunoprecipitation assay (RIA; ≤ 0.02 nmol/L), and (3) define ELISA clinical utility and pitfalls.
Andrew McKeon, Dana Olofson, Diana Anissian, Divyanshu Dubey, Eoin P. Flanagan, Max C. Herman, Sarosh R. Irani, Daniel H. Lachance, Maria A. Willrich, Sean Pittock, John R. Mills, Anastasia Zekeridou   +11 more
wiley   +1 more source

Progress Notes : a report from the Parkinson's Disease Center at Boston University Medical Center [PDF]

, 1992
News and updates from the Boston University Medical Center Parkinson's Disease ...
Parkinson's Disease Center at Boston University Medical Center
core  

Optimal set of EEG features for emotional state classification and trajectory visualization in Parkinson's disease [PDF]

, 2014
In addition to classic motor signs and symptoms, individuals with Parkinson's disease (PD) are characterized by emotional deficits. Ongoing brain activity can be recorded by electroencephalograph (EEG) to discover the links between emotional states and ...
Mohamad, Khairiyah, Yuvaraj, Rajamanickam, Ibrahim, Norlinah Mohamed, Omar, Mohd Iqbal, Murugappan, Murugappan, Sundaraj, Kenneth, Palaniappan, Ramaswamy   +6 more
core   +1 more source

Relationship between Fatigue and Nocturnal Problems Related to Parkinson's Disease [PDF]

, 2022
In patients with Parkinson's disease (PD), fatigue and sleep disturbances are important non-motor symptoms. In this study, we aimed to evaluate the relationship between fatigue and sleep disturbances in patients with Parkinson's disease (PD).
Nozawa, Narihiro, Shioda, Mukuto, Sakuramoto, Hirotaka, Suzuki, Keisuke, Onuma, Hiroki, Fujita, Hiroaki, Shiina, Tomohiko, Ogaki, Keitaro   +7 more
core   +1 more source

Longitudinal Assessment of Biomarkers in ALS: Discriminative Biomarkers for Disease Progression and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the association and discriminative performance of serum biomarkers with clinical disease progression and survival in patients with amyotrophic lateral sclerosis (ALS). Methods This retrospective study, conducted at Houston Methodist Hospital, Houston, TX, used longitudinal serum samples collected between January 2018 and ...
David R. Beers, Yueh‐Yun Lin, Jason R. Thonhoff, Aaron D. Thome, Alireza Faridar, Weihua Zhao, Shixiang Wen, Stanley H. Appel   +7 more
wiley   +1 more source

Emotion classification in Parkinson's disease by higher-order spectra and power spectrum features using EEG signals: A comparative study [PDF]

, 2014
Deficits in the ability to process emotions characterize several neuropsychiatric disorders and are traits of Parkinson's disease (PD), and there is need for a method of quantifying emotion, which is currently performed by clinical diagnosis ...
Mohamad, Khairiyah, Yuvaraj, Rajamanickam, Ibrahim, Norlinah Mohamed, Omar, Mohd Iqbal, Murugappan, Murugappan, Sundaraj, Kenneth, Satiyan, Marimuthu, Palaniappan, Ramaswamy   +7 more
core   +1 more source

The Association Between Type 2 Diabetes Mellitus and Parkinson's Disease [PDF]

, 2020
In recent years, an emerging body of evidence has forged links between Parkinson's disease (PD) and type 2 diabetes mellitus (T2DM). In observational studies, those with T2DM appear to be at increased risk of developing PD, as well as experiencing faster
de Pablo-Fernandez, E, Cheong, JLY, Noyce, AJ, Noyce, A, Foltynie, T, Cheong, J L Y   +5 more
core   +1 more source

Platelet mitochondrial complex I and IV activities are not reliable stratification biomarkers in Parkinson's disease

Journal of Parkinson’s Disease
Background Mitochondrial dysfunction, particularly complex I (CI) deficiency, is considered an integral feature of Parkinson's disease (PD). However, recent findings indicate that widespread neuronal CI deficiency in the brain is only present in a ...
Simon Ulvenes Kverneng, Sepideh Mostafavi, Yana Mikhaleva, Gard Aasmund Skulstad Johanson, Haakon Berven, Katarina Lundervold, Geir Olve Skeie, Erika Sheard, Mona Søgnen, Solveig Af Geijerstam, Therese Vetås, Michele Brischigliaro, Erika Fernandez-Vizarra, Yamila N Torres Cleuren, Christian Dölle, Charalampos Tzoulis   +15 more
doaj   +1 more source