Results 91 to 100 of about 214,205 (284)

Clinical Validation of Plasma p‐217tau in Neurological Diseases

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Plasma p‐217tau is a minimally invasive but specific biomarker for diagnosing Alzheimer's disease (AD). However, its disease specificity remains to be clinically evaluated. We validated the reliability of the p‐217tau biomarker in 12 other neurological diseases.
Takeshi Kawarabayashi, Takumi Nakamura, Ryoma Takahashi, Tetsuya Ueda, Seiji Kinoshita, Chikage Uchida, Takashi Sugawara, Kentaro Hashimoto, Kunihiko Ishizawa, Masakuni Amari, Hiroo Kasahara, Yoshio Ikeda, Masamitsu Takatama, Mikio Shoji   +13 more
wiley   +1 more source

Obstructive sleep apnea, periodic limb movements, and REM sleep without atonia are common in Parkinson's disease and correlate with motor symptom burden

Journal of Parkinson’s Disease
Background Sleep disturbances are prevalent and debilitating non-motor symptoms in patients with Parkinson's disease (PD). Objective This study aimed to explore sleep architecture and the prevalence of polysomnographic (PSG) sleep findings in PD ...
Matteo Carpi, Mariangela Pierantozzi, Mariana Fernandes, Natalia Manfredi, Raffaella Ludovisi, Michela Menegotti, Tommaso Schirinzi, Rocco Cerroni, Alessandro Stefani, Nicola Biagio Mercuri, Claudio Liguori   +10 more
doaj   +1 more source

Intraputamenal Infusion of Exogenous Neurturin Protein Restores Motor and Dopaminergic Function in the Globus Pallidus of MPTP-Lesioned Rhesus Monkeys

Cell Transplantation, 2008
The neurorestorative effects of exogenous neurturin (NTN) delivered directly into the putamen via multiport catheters were studied in 10 MPTP-lesioned rhesus monkeys expressing stable parkinsonism.
R. Grondin Ph.D., Z. Zhang, Y. Ai, F. Ding, A. A. Walton, S. P. Surgener, G. A. Gerhardt, D. M. Gash   +7 more
doaj   +1 more source

Progress Notes : a report from the Parkinson's Disease Center at Boston University Medical Center

, 1996
News and updates from the Boston University Medical Center Parkinson's Disease ...
Parkinson's Disease Center at Boston University Medical Center
core  

CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao, Rong Li, Yu‐Xiang Jiao, Kai Ma, Hong‐Qi Yang, Zheng‐Yu Sun, Jie‐Wen Zhang, Shuai Chen   +7 more
wiley   +1 more source

Levodopa Fractionation in Parkinson's Disease

, 2014
Background:Fractionation of daily levodopa dosage is one strategy to manage the almost inevitable development of symptom fluctuations in Parkinson's disease (PD).
Nyholm, Dag,, Stepien, Victoria,
core   +1 more source

Perspectives on Care for Late-Stage Parkinson's Disease [Elektronisk resurs]

, 2021
In the late stage of Parkinson's disease (PD), there is an increasing disease burden not only for the patients but also for their informal caregivers and the health and social services systems.
Schrag, Anette,, Odin, Per,, Kylberg, Marianne,, Rosqvist, Kristina,, Löfqvist, Charlotte,, Iwarsson, Susanne,, Lund University.   +6 more
core   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

DRD4 gene polymorphism and impulse control disorder induced by dopamine agonists in Parkinson's disease

Annals of Clinical and Translational Neurology
Impulse control disorders and their consequences display variability among individuals, indicating potential involvement of environmental and genetic factors.
Viviana Torres, Jesica Pérez‐Montesino, Rubén Fernández‐Santiago, Manel Fernández, Ana Camara, Yaroslau Compta, María‐José Martí, Àlex Guerra Beltran, José Rios, Francesc Valldeoriola, Mario Ezquerra   +10 more
doaj   +1 more source

RNA sequencing reveals MMP2 and TGFB1 downregulation in LRRK2 G2019S Parkinson's iPSC-derived astrocytes

Neurobiology of Disease, 2019
Non-neuronal cell types such as astrocytes can contribute to Parkinson's disease (PD) pathology. The G2019S mutation in leucine-rich repeat kinase 2 (LRRK2) is one of the most common known causes of familial PD.
Heather D.E. Booth, Frank Wessely, Natalie Connor-Robson, Federica Rinaldi, Jane Vowles, Cathy Browne, Samuel G. Evetts, Michele T. Hu, Sally A. Cowley, Caleb Webber, Richard Wade-Martins   +10 more
doaj   +1 more source