Results 111 to 120 of about 214,205 (284)
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To assess the association and discriminative performance of serum biomarkers with clinical disease progression and survival in patients with amyotrophic lateral sclerosis (ALS). Methods This retrospective study, conducted at Houston Methodist Hospital, Houston, TX, used longitudinal serum samples collected between January 2018 and ...
David R. Beers +7 more
wiley +1 more source
Updating our definitions of Parkinson's disease for a molecular age
, 2018 Clinical definitions of Parkinson's disease (PD) are over 200 years old, while neuropathological definitions-which are still the basis of how we define the disease now-are over 100 years old.
Chen-Plotkin, A. S., Zetterberg, Henrik,
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Dementia Incidence in Individuals With Parkinson's Disease in the Framingham Heart Study
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Limited information exists on incident dementia in individuals with Parkinson's disease (PD) in US community‐based samples. We examined cognitive statuses and PD diagnoses of 183 individuals in the Framingham Heart Study (FHS) to establish incident dementia, mortality rates, associations with sex, age at PD onset, and education level.
Joshi Dookhy +11 more
wiley +1 more source
Frontiers in Neurology, 2018 Writer's cramp (focal hand dystonia) is a sporadic focal dystonia that affects a specific part of the upper limb causing excessive co-contraction of antagonistic muscles.
Takeshi Shimizu +8 more
doaj +1 more source
Pharmacological Management of Parkinson's Disease
, 2017 Parkinson's disease is the second most common neurodegenerative disease with no known cure. In this thesis the currently available treatments for motor and non-motor symptoms of Parkinson's disease will be discussed, as well as emerging neuroprotective ...
Ingadóttir, Eva Lind
core
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Isolated rapid eye movement sleep behavior disorder (iRBD) is a prodromal state for Lewy body disorders and exhibits biological heterogeneity that may influence clinical expression and progression. We examined clinical features in individuals with iRBD and biomarker‐defined synucleinopathy.
Daniel Weintraub +24 more
wiley +1 more source
Neurobiology of Disease, 2019 Background: Mutations in LRRK2 are the most common cause of autosomal dominant Parkinson's disease, and the relevance of LRRK2 to the sporadic form of the disease is becoming ever more apparent.
Natalie Connor-Robson +14 more
doaj +1 more source
, 2010 Communication problems are a frequent symptom for people with Parkinson's disease (PD) which can have a significant impact on their quality-of-life. Deciding on the right management approach can be problematic though, as, with the exception of LSVT (R ...
Kröger, Bernd J. +10 more
core +1 more source
Why do patients with Parkinson's disease fall? A cross-sectional analysis of possible causes of falls. [PDF]
, 2015 BACKGROUND: Falls in Parkinson's disease (PD) are associated with significant injury, disability, hospitalization, and reduced quality of life. AIMS: To identify modifiable medical causes of falls in a cohort of PD patients.
Kaski, D +3 more
core +1 more source
Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni +19 more
wiley +1 more source