Results 101 to 110 of about 5,005,064 (282)

Characterizing Cutaneous α‐Synuclein Deposition and Seeding Activity in Parkinson's Disease Subtypes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cutaneous phosphorylated α‐synuclein (p‐syn) and α‐synuclein seeding activity are promising biomarkers for Parkinson's disease (PD), but their clinical value remains uncertain due to disease heterogeneity. This study evaluates these two biomarkers in PD patients to inform phenotype‐specific diagnosis and disease severity assessment ...
Yuting Jin, Tianyuan Yang, Minglei Liu, Haiyang Luo, Jing Yuan, Ke Zhang, Xinsheng Han, Jing Yang, Yuming Xu   +8 more
wiley   +1 more source

Are Stem Cell-Based Therapies for Parkinson's Disease Ready for the Clinic in 2016? [Elektronisk resurs]

, 2016
Recent news of an impending clinical cell transplantation trial in Parkinson's disease using parthenogenetic stem cells as a source of donor tissue have raised hopes in the patient community and sparked discussion in the research community.
Brundin, Patrik,, Barker, Roger A,, Björklund, Anders,, Parmar, Malin,, Kirkeby, Agnete,, Lund University., Thompson, Lachlan,   +6 more
core   +1 more source

Population-based studies on the epidemiology of migraine and Parkinson's disease [PDF]

, 2007
With epidemiologic analyses the effect of certain exposures on diseases can be studied in large population samples. Pharmacoepidemiology is a speciality which focuses on beneficial or harmful drug effects on the development of diseases.
Becker, Claudia
core   +1 more source

Intraputamenal Infusion of Exogenous Neurturin Protein Restores Motor and Dopaminergic Function in the Globus Pallidus of MPTP-Lesioned Rhesus Monkeys

Cell Transplantation, 2008
The neurorestorative effects of exogenous neurturin (NTN) delivered directly into the putamen via multiport catheters were studied in 10 MPTP-lesioned rhesus monkeys expressing stable parkinsonism.
R. Grondin Ph.D., Z. Zhang, Y. Ai, F. Ding, A. A. Walton, S. P. Surgener, G. A. Gerhardt, D. M. Gash   +7 more
doaj   +1 more source

Long‐Term Neurologic Exam Findings in People Diagnosed and Treated During Acute HIV Infection

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Evaluate clinical and laboratory correlates of abnormal neurologic exam findings after acute HIV infection (AHI). Methods Participants from the RV254/SEARCH 010 cohort in Bangkok underwent standardized neurologic examinations at Weeks 0 (AHI), 12, 96, and 288 following antiretroviral therapy (ART).
Kathryn B. Holroyd, Tyler Hamby, Carlo Sacdalan, Somchai Sriplienchan, Pathariya Promensa, Luxenaree Poonpitak, Netsiri Dumrongpisutikul, Eugène Kroon, Sandhya Vasan, Robert Paul, Ferron O'Campo, Lydie Trautmann, Phillip Chan, Serena Spudich, on behalf of the RV254/SEARCH 010 Study Team, Julie Ake, Sandhya Vasan, Lydie Trautmann, Merlin Robb, Trevor Crowell, Donn Colby, Diane Bolton, Shelly Krebs, Leigh Ann Eller, Morgane Rolland, Rasmi Thomas, Dominic Paquin Proulx, Suteeraporn Pinyakorn, Tyler Hamby, Mark de Souza, Ellen Turk, Amber Moodley, Gerald Quarles, Jintanat Ananworanich, Denise Hsu, Victoria Polonis, Nelson Michael, Sheila Peel, COL Eric Garges, Alexandra Schuetz, Siriwat Akapirat, Bessara Nantapinit, Pornsuk Visudhiphan, Saowanit Getchalarat, Nampueng Churikanont, Sangsulee Thamakaison, Somchai Sriplienchan, Carlo Sacdalan, Pathariya Promsena, Luxe‐naree Poonpitak, Eugene Kroon, Nitiya Chomchey, Jintana Intasan, Varaporn Pothipala, Ferron Ocampo, Nittaya Phanuphak, Nipat Teeratakulpisan, Yuwaree Pichitchok, Anchalee Avihingsanon, Opass Putcharoen, Kiat Ruxrungtham, Thanyawee Puthanakit, Sopark Manasnayakorn, Phandee Watanaboonyongcharoen, Rungsun Rerknimitr, Irini Sereti, Daniel Douek, Eli Bortiz, Frank Maldarelli, Mary Kearney, Serena Spudich, Phillip Chan, Lishomwa Ndhlovu, Guinevere Li, Michael Corley, Victor Valcour, Peter Hunt, Jacob Estes, Afam Okoye, Jeff Lifson, Claire Deleage, Nicolas Chomont, Andres Finzi, Lyle McKinnon, Henrik Zetterberg, Robert Siliciano, Robert Paul, Julie Mannarino, Jonathan Li, John Mellors, Josh Cytkor, Dan Barouch, Michael Seaman, Boris Juelg, Alex Shalek, Timothy Schacker, Ashley Haase, Mario Stevenson, Wenjun Li, Arthur Kim, Sharon Lewin, Adam Carrico, Susana Valente, Fred Hutchinson, Josh Schiffer, Guido Ferrari, Beau Ances, Alberto Bosque, Katharine Bar, Killian Pohl, David Ho, Yaoxing Huang, Michael Busch, Mohamed Abdel‐Mohsen, Johanna Gostner, Brian Agan, Fatah Kashanchi, Greg Laird, Kathryn Holroyd   +118 more
wiley   +1 more source

Distribution and impact on quality of life of the pain modalities assessed by the King's Parkinson's disease pain scale

, 2017
In Parkinson's disease, pain is a prevalent and complex symptom of diverse origin. King's Parkinson's disease pain scale, assesses different pain syndromes, thus allowing exploration of its differential prevalence and influence on the health-related ...
Rizos, Alexandra,, Carmen Rodriguez-Blazquez, Martinez-Martin, Pablo, Rizos, Alexandra, Chaudhuri, Kallol Ray, Lauren Perkins, Manuel Rojo-Abuin, Jose, Alexandra Rizos, Jose Manuel Rojo-Abuin, Perkins, Lauren, Kallol Ray Chaudhuri, Anna Sauerbier, Manuel Rojo-Abuin, Jose,, Odin, Per, Rodriguez-Blazquez, Carmen, Sauerbier, Anna, Perkins, Lauren,, Antonini, Angelo, Antonini, Angelo,, Sauerbier, Anna,, Pablo Martinez-Martin, Odin, Per,, Martinez-Martin, Pablo,, Claudia Trenkwalder, null null, Per Odin, Trenkwalder, Claudia, Lund University., Angelo Antonini, Trenkwalder, Claudia,   +29 more
core   +1 more source

RNA sequencing reveals MMP2 and TGFB1 downregulation in LRRK2 G2019S Parkinson's iPSC-derived astrocytes

Neurobiology of Disease, 2019
Non-neuronal cell types such as astrocytes can contribute to Parkinson's disease (PD) pathology. The G2019S mutation in leucine-rich repeat kinase 2 (LRRK2) is one of the most common known causes of familial PD.
Heather D.E. Booth, Frank Wessely, Natalie Connor-Robson, Federica Rinaldi, Jane Vowles, Cathy Browne, Samuel G. Evetts, Michele T. Hu, Sally A. Cowley, Caleb Webber, Richard Wade-Martins   +10 more
doaj   +1 more source

Deep Learning Pose Estimation for Phenotyping of Co‐Occurring Hyperkinetic Movement Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore whether routine outpatient video combined with deep learning‐based pose estimation and clinically interpretable kinematic features can support multi‐label phenotyping of co‐occurring hyperkinetic movement disorders (HMDs).
Laura Cif, Diane Demailly, Gabriella A. Horvàth, Juan Dario Ortigoza Escobar, Nathalie Dorison, Mayté Castro Jiménez, Cécile A. Hubsch, Thomas Wirth, Gun‐Marie Hariz, Sophie Huby, Morgan Dornadic, Zohra Souei, Muhammad Mushhood Ur Rehman, Simone Hemm, Mehdi Boulaymen, Eduardo M. Moraud, Jocelyne Bloch, Xavier Vasques   +17 more
wiley   +1 more source

DRD4 gene polymorphism and impulse control disorder induced by dopamine agonists in Parkinson's disease

Annals of Clinical and Translational Neurology
Impulse control disorders and their consequences display variability among individuals, indicating potential involvement of environmental and genetic factors.
Viviana Torres, Jesica Pérez‐Montesino, Rubén Fernández‐Santiago, Manel Fernández, Ana Camara, Yaroslau Compta, María‐José Martí, Àlex Guerra Beltran, José Rios, Francesc Valldeoriola, Mario Ezquerra   +10 more
doaj   +1 more source

Atrophic Myenteric and Submucosal Neurons Are Observed in Parkinson's Disease [Elektronisk resurs]

, 2019
Aim. Parkinson's disease is often accompanied by gastrointestinal symptoms, especially constipation. Microscopic studies of the enteric nervous system and enteric neuropathy have often been performed by immunostaining in the myenteric plexa.
Englund, Elisabet,, Lund University., Ohlsson, Bodil,   +2 more
core   +1 more source