Results 101 to 110 of about 5,338,575 (282)

Parkinson Disease [PDF]

Clinics in Geriatric Medicine, 2020
Carlos, Singer, Stephen G, Reich
openaire   +5 more sources

Updating our definitions of Parkinson's disease for a molecular age

, 2018
Clinical definitions of Parkinson's disease (PD) are over 200 years old, while neuropathological definitions-which are still the basis of how we define the disease now-are over 100 years old.
Chen-Plotkin, A. S., Zetterberg, Henrik,
core   +1 more source

Global Rather Than Vertical‐Selective Saccadic Abnormalities in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To test whether vertical saccades are preferentially affected in Progressive Supranuclear Palsy (PSP). Methods PSP patients (n = 24) were compared to age‐matched controls (n = 94) and two degenerative groups (Alzheimer's disease, n = 20; Lewy body disease, n = 50).
Duy Duan Nguyen, Mark Paine, Soohyun Lee, Amir Fazlollahi, Baibin (Ben) Wang, John D. O'Sullivan, Peter J. Nestor   +6 more
wiley   +1 more source

DRD4 gene polymorphism and impulse control disorder induced by dopamine agonists in Parkinson's disease

Annals of Clinical and Translational Neurology
Impulse control disorders and their consequences display variability among individuals, indicating potential involvement of environmental and genetic factors.
Viviana Torres, Jesica Pérez‐Montesino, Rubén Fernández‐Santiago, Manel Fernández, Ana Camara, Yaroslau Compta, María‐José Martí, Àlex Guerra Beltran, José Rios, Francesc Valldeoriola, Mario Ezquerra   +10 more
doaj   +1 more source

RNA sequencing reveals MMP2 and TGFB1 downregulation in LRRK2 G2019S Parkinson's iPSC-derived astrocytes

Neurobiology of Disease, 2019
Non-neuronal cell types such as astrocytes can contribute to Parkinson's disease (PD) pathology. The G2019S mutation in leucine-rich repeat kinase 2 (LRRK2) is one of the most common known causes of familial PD.
Heather D.E. Booth, Frank Wessely, Natalie Connor-Robson, Federica Rinaldi, Jane Vowles, Cathy Browne, Samuel G. Evetts, Michele T. Hu, Sally A. Cowley, Caleb Webber, Richard Wade-Martins   +10 more
doaj   +1 more source

Distribution and impact on quality of life of the pain modalities assessed by the King's Parkinson's disease pain scale [PDF]

, 2017
In Parkinson's disease, pain is a prevalent and complex symptom of diverse origin. King's Parkinson's disease pain scale, assesses different pain syndromes, thus allowing exploration of its differential prevalence and influence on the health-related ...
Rizos, Alexandra,, Carmen Rodriguez-Blazquez, Martinez-Martin, Pablo, Rizos, Alexandra, Chaudhuri, Kallol Ray, Lauren Perkins, Manuel Rojo-Abuin, Jose, Alexandra Rizos, Jose Manuel Rojo-Abuin, Perkins, Lauren, Kallol Ray Chaudhuri, Anna Sauerbier, Manuel Rojo-Abuin, Jose,, Odin, Per, Rodriguez-Blazquez, Carmen, Sauerbier, Anna, Perkins, Lauren,, Antonini, Angelo, Antonini, Angelo,, Sauerbier, Anna,, Pablo Martinez-Martin, Odin, Per,, Martinez-Martin, Pablo,, Claudia Trenkwalder, null null, Per Odin, Trenkwalder, Claudia, Lund University., Angelo Antonini, Trenkwalder, Claudia,, Perkins L., International Parkinson's Disease Non-Motor Group (PDNMG), Trenkwalder C., Odin P., Rojo-Abuin J. M., Chaudhuri K. R., Rodriguez-Blazquez C., Rizos A., Sauerbier A., Antonini A., EUROPAR Study Group, King's Parkinson's Disease Pain Scale (KPPS), on behalf of KPPS, EUROPAR and the IPMDS Non Motor PD Study Group, Rojo-Abuin, Jose Manuel, Martinez-Martin P.   +44 more
core   +1 more source

Diabetes‐Associated Cognitive Impairment: Pathophysiology and Emerging Therapies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Diabetes‐associated cognitive impairment (DACI) is a common yet underrecognized condition, manifesting along a spectrum from mild cognitive impairment to dementia. DACI encompasses patients who develop vascular dementia (VaD) or Alzheimer's disease (AD) with diabetes as a risk factor; however, in certain patients, particularly those lacking ...
Osman Corbali, Priyanka Menon, Halil I. Corbali, Ram Jagannathan, Allan I. Levey   +4 more
wiley   +1 more source

Atrophic Myenteric and Submucosal Neurons Are Observed in Parkinson's Disease [Elektronisk resurs]

, 2019
Aim. Parkinson's disease is often accompanied by gastrointestinal symptoms, especially constipation. Microscopic studies of the enteric nervous system and enteric neuropathy have often been performed by immunostaining in the myenteric plexa.
Englund, Elisabet,, Lund University., Ohlsson, Bodil,   +2 more
core   +1 more source

Vascular Disease, Non‐Steroidal Anti‐Inflammatory Drugs and Risk of Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives A history of vascular disease has been shown to be associated with an increased risk of Parkinson's disease, but this may be due to reverse causation. In addition, non‐steroidal anti‐inflammatory drugs are thought to reduce Parkinson's disease risk, but evidence is inconsistent and confounding by prior vascular disease is possible ...
Clare Wotton, Carol Hermon, Sarah Floud, Gillian Reeves, Isobel Barnes   +4 more
wiley   +1 more source

The effects of Parkinson's disease mimetics on the proteasomal and neurofilament systems in SH-SY5Y cells [PDF]

, 2006
Mitochondrial impairment, glutathione depletion and oxidative stress have been implicated in the pathogenesis of Parkinson's disease, linked recently to proteasomal dysfunction.
Caneda-Ferrón, B, Caneda-FerroÌn, Begoña   +1 more
core