Results 101 to 110 of about 214,205 (284)

Quality of Life and Mild Cognitive Impairment in Early Parkinson's Disease: Does Subtype Matter?

, 2014
We evaluated the association between mild cognitive impairment (MCI) subtypes and quality of life (QoL) in 219 newly diagnosed Parkinson's disease (PD) patients without dementia.
Khoo, Tien Kheng, Gordon W., W., Lawson, Rachael A, Taylor, John-Paul, Burn, David, Yarnall, Alison, Barker, Roger A, Duncan, Gordon W, Barker, Roger, Yarnall, Alison J, Breen, David, Lawson, Rachael, Khoo, Tien K, Collerton, Daniel, Breen, David P, Burn, David J   +15 more
core   +1 more source

Bringing Advanced Therapies for Parkinson's Disease to the Clinic [Elektronisk resurs] : The Scientist's Perspective

, 2021
After many years of preclinical development, cell and gene therapies have advanced from research tools in the lab to clinical-grade products for patients, and today they constitute more than a quarter of all new Phase I clinical trials for Parkinson's ...
Tomishima, Mark,, Kirkeby, Agnete,, Lund University.   +2 more
core   +1 more source

Relationship Between Neurologic Symptoms and Signs and FMR1 Genotype in Premutation Carriers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Fragile X‐associated Tremor/Ataxia Syndrome (FXTAS) is the most severe late‐onset condition caused by a premutation in the FMR1 gene, characterized by expanded CGG triplet repeats of 55–200. Clinical presentations of FXTAS, including gait ataxia, kinetic tremor, cognitive decline, and rare Parkinsonism, are linked to ...
Flora Tassone, Freddy Chafota, Miguel E. Rentería, Randi J. Hagerman, Ellery Santos, Anna Atkinson, Nicholas G. Martin, Elsdon Storey, Danuta Z. Loesch   +8 more
wiley   +1 more source

Parkinson′s disease

Annals of Indian Academy of Neurology, 2011
Behari, Madhuri, Bhattacharyya, Kalyan Brata, Borgohain, Rupam, Das, Shyamal Kumar, Ghosh, Bhaskar, Kishore, Asha, Krishnan, Syam, Mridula, K Rukmini, Muthane, Uday, Pal, Pramod Kumar, Sankhla, Charulata, Shukla, Garima   +11 more
  +8 more sources

Effectiveness of rTMS on Working Memory and Inhibitory Impairments in Patients With Post‐Stroke Executive Deficits

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Considerable efforts have been dedicated to developing effective treatments for post‐stroke executive impairment (PSEI), among which repetitive transcranial magnetic stimulation (rTMS) has shown great potential. This study aimed to investigate the therapeutic effects of high‐frequency rTMS on working memory (WM) and response ...
Mengting Lao, Rongwei Du, Zhujun Wang, Yang Gao, Meiling Cheng, Xianglong Wang, Wen Wu   +6 more
wiley   +1 more source

Models of probabilistic category learning in Parkinson's disease: Strategy use and the effects of L-dopa

, 2010
Probabilistic category learning (PCL) has become an increasingly popular paradigm to study the brain bases of learning and memory. It has been argued that PCL relies on procedural habit learning, which is impaired in Parkinson's disease (PD). However, as
Lagnado, DA, Shanks, DR, Jahanshahi, M, Speekenbrink, M, Wilkinson, L   +4 more
core  

GAD65 Antibody ELISA With Extended Reportable Range: Validation and Guidance for Neurological Practice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To (1) validate GAD65‐ELISA detection and quantification for type 1 diabetes mellitus and autoimmune neurological diagnoses, (2) correlate ELISA results (reference range < 5 IU/mL) with established radioimmunoprecipitation assay (RIA; ≤ 0.02 nmol/L), and (3) define ELISA clinical utility and pitfalls.
Andrew McKeon, Dana Olofson, Diana Anissian, Divyanshu Dubey, Eoin P. Flanagan, Max C. Herman, Sarosh R. Irani, Daniel H. Lachance, Maria A. Willrich, Sean Pittock, John R. Mills, Anastasia Zekeridou   +11 more
wiley   +1 more source

Creation of a machine learning-based model for early identification of mild cognitive impairment risk in Parkinson's disease: A PD research center-based population study

Journal of Parkinson’s Disease
Background This study aimed to use data from the PD-MDCNC database to develop a risk prediction model using machine learning (ML) methods for the early identification of the risk of mild cognitive impairment in Parkinson's disease (PD-MCI) within a ...
Zhengting Yang, Sufang Liu, Li Wang, Yaoling Duan, Qiu Deng, Qiang Sun, Jing Tian, Puqing Wang, Min Zhou   +8 more
doaj   +1 more source

Spreading of α-synuclein in the face of axonal transport deficits in Parkinson's disease: A speculative synthesis

Neurobiology of Disease, 2015
Parkinson's disease (PD) is mainly attributed to degeneration of dopamine neurons in the substantia nigra, but its etiopathogenesis also includes impaired protein clearance and axonal transport dysfunction, among others. The spread of α-synuclein (α-syn)
Jennifer T. Lamberts, Erin N. Hildebrandt, Patrik Brundin   +2 more
doaj   +1 more source

Speech Prosody Across Stimulus Types for Individuals with Parkinson's Disease [PDF]

, 2019
Up to 89% of the individuals with Parkinson's disease (PD) experience speech problem over the course of the disease. Speech prosody and intelligibility are two of the most affected areas in hypokinetic dysarthria. However, assessment of these areas could
Schneider, Christine B., Ma, Joan K-Y, Storch, Alexander, Hoffmann, Rüdiger   +3 more
core   +1 more source