Results 61 to 70 of about 9,423,446 (404)
, 1998 Lewy bodies and Lewy neurites are the defining neuropathological characteristics of Parkinson’s disease and dementia with Lewy bodies. They are made of abnormal filamentous assemblies of unknown composition.
M. Spillantini +5 more
semanticscholar +1 more source
Parkinson’s disease: etiopathogenesis and treatment
Journal of Neurology Neurosurgery & Psychiatry, 2020 The concept of ‘idiopathic’ Parkinson’s disease (PD) as a single entity has been challenged with the identification of several clinical subtypes, pathogenic genes and putative causative environmental agents.
J. Jankovic, E. Tan
semanticscholar +1 more source
FEBS Letters, EarlyView.Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu +17 more
wiley +1 more source
Environmental Exposures and Parkinson's Disease. [PDF]
, 2016 Parkinson's disease (PD) affects millions around the world. The Braak hypothesis proposes that in PD a pathologic agent may penetrate the nervous system via the olfactory bulb, gut, or both and spreads throughout the nervous system. The agent is unknown,
Litvan, Irene, Nandipati, Sirisha
core +2 more sources
Incidence of Parkinson's disease: variation by age, gender, and race/ethnicity.
American Journal of Epidemiology, 2003 The goal of this study was to estimate the incidence of Parkinson's disease by age, gender, and ethnicity. Newly diagnosed Parkinson's disease cases in 1994-1995 were identified among members of the Kaiser Permanente Medical Care Program of Northern ...
Stephen Van Den Eeden +6 more
semanticscholar +1 more source
Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation
FEBS Letters, EarlyView.The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen +2 more
wiley +1 more source
Psychogenic Tremor: A Video Guide to Its Distinguishing Features
Tremor and Other Hyperkinetic Movements, 2014 Background: Psychogenic tremor is the most common psychogenic movement disorder. It has characteristic clinical features that can help distinguish it from other tremor disorders.
Joseph Jankovic, Mary Ann Thenganatt
doaj +1 more source
PhoneMD: Learning to Diagnose Parkinson's Disease from Smartphone Data
, 2018 Parkinson's disease is a neurodegenerative disease that can affect a person's movement, speech, dexterity, and cognition. Clinicians primarily diagnose Parkinson's disease by performing a clinical assessment of symptoms. However, misdiagnoses are common.
Karlen, Walter, Schwab, Patrick
core +1 more source
Extended Timed Up and Go assessment as a clinical indicator of cognitive state in Parkinson\u27s disease [PDF]
, 2017 Objective: To evaluate a modified extended Timed Up and Go (extended-TUG) assessment against a panel of validated clinical assessments, as an indicator of Parkinson’s disease (PD) severity and cognitive impairment. Methods: Eighty-seven participants with
Anderton, R +7 more
core +2 more sources
Current and projected future economic burden of Parkinson’s disease in the U.S.
npj Parkinson's Disease, 2020 Parkinson’s disease (PD) is one of the world’s fastest growing neurological disorders. Much is unknown about PD-associated economic burdens in the United States (U.S.) and other high-income nations.
Wenya Yang +10 more
semanticscholar +1 more source