Results 61 to 70 of about 9,561,546 (382)

Visual exploration in Parkinson’s disease and Parkinson’s disease dementia [PDF]

Brain, 2013
Parkinson's disease, typically thought of as a movement disorder, is increasingly recognized as causing cognitive impairment and dementia. Eye movement abnormalities are also described, including impairment of rapid eye movements (saccades) and the fixations interspersed between them.
Michael P. Clarke, David J. Burn, Samuel B. Hutton, Urs Peter Mosimann, Urs Peter Mosimann, Neil Archibald   +5 more
openaire   +6 more sources

Biophysical analysis of angiotensin II and amyloid‐β cross‐interaction in aggregation and membrane disruption

FEBS Letters, EarlyView.
Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia, Eric Catalina‐Hernandez, Maialen Cabrerizo‐Idiazabal, Ramon Barnadas‐Rodríguez, Mario Lopez‐Martin, Alex Peralvarez‐Marin   +5 more
wiley   +1 more source

Paired-Pulse Inhibition in the Auditory Cortex in Parkinson's Disease and Its Dependence on Clinical Characteristics of the Patients

Parkinson's Disease, 2011
We aimed to determine the value of the paired-pulse inhibition (PPI) in the auditory cortex in patients with Parkinson's disease (PD) and analyze its dependence on clinical characteristics of the patients. The central (Cz) auditory evoked potentials were
Elena Lukhanina, Natalia Berezetskaya, Irina Karaban   +2 more
doaj   +1 more source

The impact of a parkinsonian lesion on dynamic striatal dopamine transmission depends on nicotinic receptor activation

Neurobiology of Disease, 2015
Dopamine function is disturbed in Parkinson's disease (PD), but whether and how release of dopamine from surviving neurons is altered has long been debated.
Katie A. Jennings, Nicola J. Platt, Stephanie J. Cragg   +2 more
doaj   +1 more source

Spatial judgment in Parkinson's disease: Contributions of attentional and executive dysfunction [PDF]

, 2019
Spatial judgment is impaired in Parkinson's disease (PD), with previous research suggesting that disruptions in attention and executive function are likely contributors.
Cronin-Golomb, Alice, Moon, Kathryn L.M., Neargarder, Sandy, Salazar, Robert D.   +3 more
core   +1 more source

CCT4 promotes tunneling nanotube formation

FEBS Letters, EarlyView.
Tunneling nanotubes (TNTs) are membranous tunnel‐like structures that transport molecules and organelles between cells. They vary in thickness, and thick nanotubes often contain microtubules in addition to actin fibers. We found that cells expressing monomeric CCT4 generate many thick TNTs with tubulin.
Miyu Enomoto, Akiko Asada, Taro Saito, Kanae Ando   +3 more
wiley   +1 more source

Treadmill exercise reverses dendritic spine loss in direct and indirect striatal medium spiny neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease

Neurobiology of Disease, 2014
Exercise has been shown to be beneficial for Parkinson's disease (PD). A major interest in our lab has been to investigate how exercise modulates basal ganglia function and modifies disease progression.
William A. Toy, Giselle M. Petzinger, Brian J. Leyshon, Garnik K. Akopian, John P. Walsh, Matilde V. Hoffman, Marta G. Vučković, Michael W. Jakowec   +7 more
doaj   +1 more source

Palliative care and Parkinson's disease : meeting summary and recommendations for clinical research [PDF]

, 2017
Introduction: Palliative care is an approach to caring for patients and families affected by serious illnesses that focuses on the relief of suffering through the management of medical symptoms, psychosocial issues, advance care planning and spiritual ...
Bekelman, David, Carter, Julie, Carter, Julie H., Fox, Siobhán, Galifianakis, Nicholas, Galifianakis, Nicholas B., Johnson, Miriam, Johnson, Miriam J., Katz, Maya, Kluger, Benzi, Kluger, Benzi M., Kutner, Jean, Kutner, Jean S., Miyasaki, Janis, Richfield, Edward, Richfield, Edward W., Subramanian, Indu, Timmons, Suzanne   +17 more
core   +1 more source

Parkinson’s disease: etiopathogenesis and treatment

Journal of Neurology Neurosurgery & Psychiatry, 2020
The concept of ‘idiopathic’ Parkinson’s disease (PD) as a single entity has been challenged with the identification of several clinical subtypes, pathogenic genes and putative causative environmental agents.
J. Jankovic, E. Tan
semanticscholar   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source