Results 71 to 80 of about 9,561,546 (382)

Everyday walking with Parkinson's disease: understanding personal challenges and strategies [PDF]

, 2008
PURPOSE: This qualitative study was designed to explore the personal experience of everyday walking with Parkinson's disease (PD), the challenges and the strategies employed to compensate for difficulties, to help contextualise the scientific knowledge ...
Birleson, Angela, Hetherington, Victoria, Jones, Diana, Kwakkel, Gert, Nieuwboer, Alice, Rochester, Lynn, van Wegen, Erwin, Willems, Anne-Marie   +7 more
core   +2 more sources

Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson’s disease

Nature Genetics, 2014
We conducted a meta-analysis of Parkinson's disease genome-wide association studies using a common set of 7,893,274 variants across 13,708 cases and 95,282 controls. Twenty-six loci were identified as having genome-wide significant association; these and
M. Nalls, N. Pankratz, C. Lill, Chuong B. Do, D. Hernandez, D. Hernandez, M. Saad, M. Saad, M. Saad, A. Destefano, A. Destefano, E. Kara, J. Bras, Manu Sharma, C. Schulte, Margaux F. Keller, S. Arepalli, Christopher T Letson, Connor Edsall, H. Stefánsson, Xinmin Liu, Hannah A. Pliner, Joseph H. Lee, R. Cheng, M. Ikram, J. Ioannidis, G. Hadjigeorgiou, J. Bis, Miguel Ángel Martínez, Miguel Ángel Martínez, J. Perlmutter, A. Goate, K. Marder, B. Fiske, Margaret Sutherland, G. Xiromerisiou, R. Myers, L. Clark, K. Stefánsson, J. Hardy, P. Heutink, Honglei Chen, N. Wood, H. Houlden, H. Payami, A. Brice, A. Brice, W. Scott, T. Gasser, L. Bertram, N. Eriksson, T. Foroud, A. Singleton   +52 more
semanticscholar   +1 more source

Mitochondria‐associated membranes (MAMs): molecular organization, cellular functions, and their role in health and disease

FEBS Open Bio, EarlyView.
Mitochondria‐associated membranes (MAMs) are contact sites between the endoplasmic reticulum and mitochondria that regulate calcium signaling, lipid metabolism, autophagy, and stress responses. This review outlines their molecular organization, roles in cellular homeostasis, and how dysfunction drives neurodegeneration, metabolic disease, cancer, and ...
Viet Bui, Maryline Santerre, Natalia Shcherbik, Bassel E Sawaya   +3 more
wiley   +1 more source

Psychogenic Tremor: A Video Guide to Its Distinguishing Features

Tremor and Other Hyperkinetic Movements, 2014
Background: Psychogenic tremor is the most common psychogenic movement disorder. It has characteristic clinical features that can help distinguish it from other tremor disorders.
Joseph Jankovic, Mary Ann Thenganatt
doaj   +1 more source

Adiponectin paradox as a therapeutic target of the cancer evolvability in aging

Neoplasia: An International Journal for Oncology Research, 2021
Recent study suggests that protofibril-formation of amyloidogenic proteins (APs) might be involved in evolvability, an epigenetic inheritance of multiple stresses, in various biological systems.
Yoshiki Takamatsu, Gilbert Ho, Ryoko Wada, Satoshi Inoue, Makoto Hashimoto   +4 more
doaj   +1 more source

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source

Frequency of Non-motor Symptoms in Parkinson's Patients With Motor Fluctuations

Frontiers in Neurology, 2021
Background: Non-motor symptoms (NMS), including neuropsychiatric, sleep, autonomic, and sensory domains, are an integral aspect of the clinical presentation of Parkinson disease (PD) and affect neurocognitive functioning as well as patients' and ...
Mariana Fernandes, Mariangela Pierantozzi, Mariangela Pierantozzi, Alessandro Stefani, Alessandro Stefani, Carlo Cattaneo, Erminio A. Bonizzoni, Rocco Cerroni, Nicola Biagio Mercuri, Nicola Biagio Mercuri, Claudio Liguori, Claudio Liguori, Claudio Liguori   +12 more
doaj   +1 more source

Common Genetic Variant Association with Altered HLA Expression, Synergy with Pyrethroid Exposure, and Risk for Parkinson's Disease: An Observational and Case-Control Study. [PDF]

, 2015
Background/objectivesThe common non-coding single nucleotide polymorphism (SNP) rs3129882 in HLA-DRA is associated with risk for idiopathic Parkinson's disease (PD).
Boss, JM, Bronstein, J, Chang, J, Chung, J, Cook, DA, Factor, SA, Kannarkat, GT, Lee, J-K, Paul, KC, Ritz, B, Sandy, E, Tansey, MG   +11 more
core   +2 more sources

Current and projected future economic burden of Parkinson’s disease in the U.S.

npj Parkinson's Disease, 2020
Parkinson’s disease (PD) is one of the world’s fastest growing neurological disorders. Much is unknown about PD-associated economic burdens in the United States (U.S.) and other high-income nations.
Wenya Yang, J. Hamilton, C. Kopil, J. Beck, C. Tanner, R. Albin, E. Ray Dorsey, N. Dahodwala, Inna Cintina, P. Hogan, Ted Thompson   +10 more
semanticscholar   +1 more source

Multimodal Autonomic Biomarkers Predict Phenoconversion in Pure Autonomic Failure

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Pure autonomic failure (PAF) presents with autonomic failure without other neurological features. A third develop central neurological features, fulfilling criteria for multiple system atrophy (MSA) and Lewy body diseases (LBD), including Parkinson's disease and Dementia with Lewy bodies.
S. Koay, E. Vichayanrat, F. Bremner, F. Valerio, R. Mackenzie, G. Chiaro, G. Ingle, P. McNamara, L. Watson, J. N. Panicker, M. P. Lunn, C. Mathias, V. Iodice   +12 more
wiley   +1 more source