Results 71 to 80 of about 9,647,508 (315)

Quantitative analysis of language production in Parkinson's disease using a cued sentence generation task [PDF]

, 2012
The present study examined language production skills in Parkinson's disease (PD) patients. A unique cued sentence generation task was created in order to reduce demands on memory and attention.
Corthals, Paul, De Letter, Miet, Santens, Patrick, Van Borsel, John, Vanhoutte, Sarah   +4 more
core   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Inter-hemispheric EEG coherence analysis in Parkinson's disease : Assessing brain activity during emotion processing [PDF]

, 2014
Parkinson’s disease (PD) is not only characterized by its prominent motor symptoms but also associated with disturbances in cognitive and emotional functioning.
A Ariatti, A Cronin-Golomb, A Morita, A Suzuki, A Tessitore, AD Lawrence, AD Lawrence, AEB Cancelliere, AF Leuchter, AT Beck, B Pillon, BE Levin, C Dara, C Schröder, CC French, CF Lima, CL Yeager, D Bowers, D Schellberg, E Mohr, G Nolte, GG Celesia, H Cohen, H Hinrichs, H Kober, HL Chen, HM Gray, IH Gotlib, J Busk, J Mikels, J Péron, J Redondo, JA Obeso, JC Shaw, JF Caekebeke, JJ Gross, JM Savitt, JT Yip, K Dujardin, K Sergerie, Kenneth Sundaraj, KH Kim, Khairiyah Mohamad, KM Miller, LC Fonseca, M Lotze, M Murugappan, M. Murugappan, M. Satiyan, MA Guevara, MD Pell, MD Pell, MF Folstein, MI Ventura, MJ Wieser, MJ Wieser, MK Beyer, MM Hoehn, Mohd Iqbal Omar, MY Neufeld, Norlinah Mohamed Ibrahim, P Garrido-Vásquez, P Madeley, P Salgado-Pineda, PC Petrantonakis, PJ Lang, R Adolphs, R Adolphs, R Bastiaanse, R Soikkeli, R Sprengelmeyer, R Yuvaraj, R. Palaniappan, R. Yuvaraj, RA Roemer, RC Oldfield, RJ Davidson, RJR Blair, RW Thatcher, S Jerritta, S Paulmann, SK Hadjidimitriou, T Baumgartner, T Gasser, TF Newton, TP Bouchard, US Clark, Y Kan, Y Wang   +88 more
core   +1 more source

Longitudinal Study of Salivary Biomarkers in the Definition of Clinico‐Molecular Progression of Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
Longitudinal changes in salivary biomarkers in Parkinson’s disease (PD) from early (T0) to 4‐year follow‐up (T1), quantified by ELISA: oligomeric and total α‐synuclein, total and phosphorylated tau, MAP1LC3B (autophagy), and TNFa (inflammation). Blue arrows indicate direction of change at T1 vs T0 (up = increase; down = decrease).
Maria Ilenia De Bartolo, Daniele Belvisi, Matteo Costanzo, Claudia Caturano, Francesco Emanuele Bellomi, Carolina Cutrona, Flavia Aiello, Giorgio Leodori, Massimo Marano, Romina Mancinelli, Antonella Conte, Giovanni Fabbrini, Alfredo Berardelli, Giorgio Vivacqua   +13 more
wiley   +1 more source

Neuroimaging in pre-motor Parkinson's disease

NeuroImage: Clinical, 2017
The process of neurodegeneration in Parkinson's disease begins long before the onset of clinical motor symptoms, resulting in substantial cell loss by the time a diagnosis can be made. The period between the onset of neurodegeneration and the development
Thomas R. Barber, Johannes C. Klein, Clare E. Mackay, Michele T.M. Hu   +3 more
doaj   +1 more source

Resveratrol suppresses the growth and metastatic potential of cervical cancer by inhibiting STAT3Tyr705 phosphorylation

Cancer Medicine, 2020
Aberrant signal transducer and activator of transcription 3 (STAT3) signaling promotes the initiation and progression of cancer in humans by either inhibiting apoptosis or inducing cell proliferation, angiogenesis, invasion, and metastasis.
Xiaodong Sun, Qianqian Xu, Lian Zeng, Lixia Xie, Qiang Zhao, Hongxia Xu, Xuanbin Wang, Nan Jiang, Pan Fu, Ming Sang   +9 more
doaj   +1 more source

Computational analysis of the LRRK2 interactome. [PDF]

, 2015
LRRK2 was identified in 2004 as the causative protein product of the Parkinson's disease locus designated PARK8. In the decade since then, genetic studies have revealed at least 6 dominant mutations in LRRK2 linked to Parkinson's disease, alongside one ...
Denny, P, Lewis, PA, Lovering, RC, Manzoni, C   +3 more
core  

Superoxide Radical Dismutation as New Therapeutic Strategy in Parkinson’s Disease [PDF]

, 2017
open4siAging is the biggest risk factor for developing many neurodegenerative disorders, including idiopathic Parkinson's disease (PD). PD is still an incurable disorder and the available medications are mainly directed to the treatment of symptoms in ...

core   +1 more source

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source

Neuroprotection and Functional Recovery Associated with Decreased Microglial Activation Following Selective Activation of mGluR2/3 Receptors in a Rodent Model of Parkinson's Disease

Parkinson's Disease, 2010
Clinical trials have demonstrated positive proof of efficacy of dual metabotropic glutamate receptor 2/3 (mGluR2/3) agonists in both anxiety and schizophrenia.
Hugh Chan, Helen Paur, Anthony C. Vernon, Virginia Zabarsky, Krishna P. Datla, Martin J. Croucher, David T. Dexter   +6 more
doaj   +1 more source