Results 191 to 200 of about 9,306,982 (363)

Genetics‐Based Targeting Strategies for Precise Neuromodulation

Advanced Science, EarlyView.
In this Review, the fundamental principles and implementation protocols of genetics‐based precision neuromodulation are first introduced. Then, wireless and low‐invasive strategies based on nano‐transducing materials are highlighted, along with a dissection and analysis of the strengths and weaknesses of representative studies.
Yuyuan He, Zhidong Wei, Jianda Xu, Fei Jin, Tong Li, Lili Qian, Juan Ma, Weiying Zheng, Negar Javanmardi, Ting Wang, Kangjian Sun, Zhang‐Qi Feng   +11 more
wiley   +1 more source

α-Synuclein and Parkinson’s disease

, 1999
Robert E. Burke
openalex   +1 more source

PH1 RISK OF PNEUMONIA DUE TO INCIDENT ANTIPSYCHOTIC DRUG USE AMONG PARKINSON’S DISEASE PATIENTS [PDF]

Value in Health, 2019
E. Pittman, Marie Barnard, S Inguva, Yi Yang   +3 more
openaire   +2 more sources

Network Desynchronization with Sine Waves: from Synchrony to Asynchrony by Periodic Stimulation

Advanced Science, EarlyView.
Exogenous alternating current fields are explored and interact with cerebral cortex slow waves in vitro and in silico. Varying frequency and amplitude of sine waves result in distinct network dynamics, from phase‐locking and entrainment to desynchronization. These responses occupy specific regions within the parameter space.
Joana Covelo, Martina Cortada, Gianni V. Vinci, Maurizio Mattia, Maria V. Sanchez‐Vives   +4 more
wiley   +1 more source

Dynein‐Dependent Endo‐Lysosomal Degradation Drives Lewy Body Disorders Accompanied by Aβ Pathology

Advanced Science, EarlyView.
This study investigates the impact of Aβ plaques on α‐synuclein (αSyn) pathologies in dementia with Lewy bodies (DLB). Co‐culturing primary neurons with AD mouse brain slices reveals impaired dynein‐dependent organelle trafficking, affecting αSyn degradation. Activating Rab7 restores this process, reducing αSyn inclusions.
Linlin Zhou, Yuwei Wang, Yu Liu, Feipeng Zhu, Ge Gao, Chengjie Li, Pu Ai, Jingying Xu, Junxin Wang, Long Guo, Yuting Guan, Virginia Man‐Yee Lee, Jianjun Chen, Jialin Zheng, Qihui Wu   +14 more
wiley   +1 more source

Mitochondrial involvement in Parkinson’s disease, Huntington’s disease, hereditary spastic paraplegia and Friedreich’s ataxia

, 1999
Anthony H.V. Schapira
openalex   +1 more source

Pesticides and Parkinson’s Disease [PDF]

, 2001
Todd Sherer, Ranjita Betarbet, J. Timothy Greenamyre   +2 more
openalex   +1 more source

Listerin Alleviates Alzheimer's Disease through IRE1‐mediated Decay of TLR4 mRNA

Advanced Science, EarlyView.
Alzheimer's disease (AD) progression is influenced by microglia‐mediated neuroinflammation. Here, it is demonstrated that Listerin suppresses neuroinflammatory signaling and cognitive impairment in AD models by triggering IRE1α‐mediated TLR4 mRNA decay. Adenoviral Listerin delivery reduces amyloid‐β pathology, positioning it as a new therapeutic target.
Fei Qin, Runyu Cao, Xuemei Bai, Jiahua Yuan, Wanwei Sun, Yi Zheng, Xiaopeng Qi, Wei Zhao, Bingyu Liu, Chengjiang Gao   +9 more
wiley   +1 more source

Parasomnia as an occasion for the diagnosis of Parkinson’s disease [PDF]

, 2001
Masayuki Miyamoto, Tomoyuki Miyamoto, Hidehiro Takekawa, Jin Kubo, Koichi Hirata   +4 more
openalex   +1 more source

Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease

Cell, 2016
T. Sampson, Justine W. Debelius, Taren M. Thron, Stefan Janssen, Gauri G. Shastri, Z. Ilhan, Collin Challis, Catherine E. Schretter, S. Rocha, V. Gradinaru, M. Chesselet, A. Keshavarzian, K. Shannon, R. Krajmalnik-Brown, P. Wittung-Stafshede, R. Knight, S. Mazmanian   +16 more
semanticscholar   +1 more source