Results 181 to 190 of about 263,626 (317)

Long-Term Safety and Efficacy of Repeated Cycles of RimabotulinumtoxinB in the Treatment of Chronic Sialorrhea: Results of the OPTIMYST Trial

Neurology and Therapy
Introduction Botulinum toxin injections into the salivary glands inhibit saliva production by reducing the release of acetylcholine at the parasympathetic nerve terminals within the salivary gland.
Rajesh Pahwa, Eric Molho, Mark Lew, Khashayar Dashtipour, Ramon A. Gil, Fredy J. Revilla, Thomas Clinch, Peibing Qin, Stuart H. Isaacson, on behalf of the OPen Label Trial of Intraglandular MYobloc injections for Sialorrhea Treatment (OPTIMYST) study group   +9 more
doaj   +1 more source

Additional file 1: of Identification of plasma microRNA expression changes in multiple system atrophy and Parkinsonâ s disease

, 2019
Table S1. miRNAs with significantly higher and lower expression compared to healthy controls in microarray analysis. (DOCX 38 kb)
Uwatoko, Hisashi, Hama, Yuka, Iwata, Ikuko, Shirai, Shinichi, Matsushima, Masaaki, Yabe, Ichiro, Utsumi, Jun, Sasaki, Hidenao   +7 more
openaire   +1 more source

Genes, Aging, and Parkinson’s Disease

, 2017
Aging is the principal risk factor for Parkinson’s disease (PD). The importance of the genetic and environmental factors influencing natural aging for PD etiopathogenesis, however, is dimly understood.
Pier G. Mastroberardino, Chiara Milanese, Milanese, Chiara, Mastroberardino, Pier G.   +3 more
core   +1 more source

Fibronectin1‐Expressing Subicular Circuits Selectively Govern the Retrieval of Novel Object Recognition

Advanced Science, EarlyView.
Fibronectin 1 (FN1)‐expressing subicular subpopulations encode novel object preference and selectively govern retrieval of novel object recognition (NOR) via affecting excitability of entorhinal‐projecting circuit through large conductance Ca2+‐activated potassium (BK) channel. ABSTRACT Novel object recognition (NOR), referring to the cognitive ability
Fan Fei, Jiaying Shi, Jing Xi, Yixiang Xu, Shuye Ying, Xukun Fan, Wangjialu Lu, Zhisheng Li, Menghan Li, Yu Wang, Li Cheng, Lin Yang, Lingyu Xu, Zhong Chen, Cenglin Xu, Yi Wang   +15 more
wiley   +1 more source

Additional file 5: of Identification of plasma microRNA expression changes in multiple system atrophy and Parkinsonâ s disease

, 2019
Figure S1. Î CT values for the control, MSA-C, MSA-P, and PD groups in qPCR. qPCR analysis of miRNAs in the plasma of control participants and patients with MSA-C, MSA-P, and PD revealed no statistically significant expression differences for a) hsa-miR-15b-5p, b) hsa-miR-663a, and c) hsa-miR-4736 among the control, MSA-C, MSA-P, and PD groups.
Uwatoko, Hisashi, Hama, Yuka, Iwata, Ikuko, Shirai, Shinichi, Matsushima, Masaaki, Yabe, Ichiro, Utsumi, Jun, Sasaki, Hidenao   +7 more
openaire   +1 more source

Carotid Body Transplants as a Therapy for Parkinson’s Disease [PDF]

, 2013
Affecting over 1.5 million people across the world, Parkinson's disease is a progressive neurological condition characterized, in part, by the loss of dopaminergic neurons in the substantia nigra pars compacta.
Gil, Carmen (Coordinador), Muñoz Manchado, Ana Belén, Martínez, Ana (Coordinador), Toledo Aral, Juan José, Villadiego Luque, Francisco Javier, Méndez-Ferrer, Simón, López Barneo, José   +6 more
core  

Protein Disulfide Isomerase Disassembles TDP‐43/G3BP1 Condensates and Antagonizes TDP‐43 Pathological Aggregates

Advanced Science, EarlyView.
Cytoplasmic aggregation of TDP‐43 is a common pathological feature in amyotrophic lateral sclerosis, frontotemporal lobar degeneration, and Alzheimer's disease with TDP‐43 pathology. This study reports that wild‐type PDI slows down phase separation of TDP‐43 through direct interaction with TDP‐43.
Jia‐Qi Liu, Hao Liu, Yu‐Xuan Sun, Yuying Li, Xiangyi Liu, Li‐Qiang Wang, Zhaofei Yang, Qi Fu, Xiaojiao Xu, Jie Chen, Yingshuang Zhang, Jun Zhou, Weidong Le, Mengchao Cui, Yi Liang   +14 more
wiley   +1 more source

Beyond the Classic Segawa Disease, -Associated Neurodegenerative Parkinsonism: Practical Considerations for Physicians [PDF]

Journal of Movement Disorders, 2017
Jirat Chenbhanich, Jirada Sringean, Roongroj Bhidayasiri   +2 more
doaj   +1 more source

A case of neuroleptic malignant syndrome on withdrawal of benzhexol [PDF]

, 2010
The neuroleptic malignant syndrome is a rare and potentially lethal reaction which is usually associated with the use of medications with antidopaminergic properties.
Ferry, Peter, Lofaro, Thomas, Falzon, Stephanie   +2 more
core  

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source