Results 161 to 170 of about 263,626 (317)

Simple and Complex Phonic Tics in Tourette Syndrome

Brain Sciences
Tourette syndrome (TS) is the most common cause of tics. Tics are classified as motor and phonic tics. The latter (previously also referred to as “vocal tics”) are manifested by simple sounds (simple phonic tics) or complex, often semantically meaningful
José Fidel Baizabal-Carvallo, Joseph Jankovic   +1 more
doaj   +1 more source

Additional file 1: Figure S1. of The RAB39B p.G192R mutation causes X-linked dominant Parkinsonâ s disease

, 2015
Pedigrees with variants of unknown significance. Pedigrees in which the RAB39B (A) c.428C>G (p.A143G) and (B) c.624_626delGAG (p.R209del) variants were observed. Individuals affected with Parkinsonâ s disease are represented with black symbols, unaffected individuals with open symbols.
Mata, Ignacio, Yongwoo Jang, Chun-Hyung Kim, Hanna, David, Dorschner, Michael, Samii, Ali, Pinky Agarwal, Roberts, John, Klepitskaya, Olga, Shprecher, David, Chung, Kathryn, Factor, Stewart, Espay, Alberto, Revilla, Fredy, Higgins, Donald, Litvan, Irene, Leverenz, James, Yearout, Dora, Inca-Martinez, Miguel, Martinez, Erica, Thompson, Tiffany, Cholerton, Brenna, Shu-Ching Hu, Edwards, Karen, Kim, Kwang-Soo, Zabetian, Cyrus   +25 more
openaire   +1 more source

Multifunctional Gold Nanocluster‐Based PROTAC System for Targeted Degradation of Phosphorylated Tau and Modulation of Neuroinflammation in Alzheimer's Disease

Advanced Functional Materials, EarlyView.
We present a novel proteolysis‐targeting chimera (PROTAC) system conjugated to lipoic acid gold nanoclusters (PLANC), designed to degrade pTau, regulate inflammatory signaling, and effectively traverse the blood‐brain barrier (BBB). PLANC degraded pTau at various phosphorylation sites, with mechanistic studies confirming proteasome‐mediated degradation
Sarah Nevins, Callan D. McLoughlin, Wan‐Kyu Ko, Hye Kyu Choi, Brandon Conklin, Joshua B. Stein, Yannan Hou, Hongwon Kim, Rohan Khulbe, Ki‐Bum Lee   +9 more
wiley   +1 more source

Multimodal oculomotor assessment reveals prodromal markers of Parkinson’s disease in non-manifesting LRRK2 G2019S mutation carriers

npj Parkinson's Disease
Oculomotor behaviour changes in patients with Parkinson’s disease (PD) are a promising source of prodromal disease markers. Capitalizing on this phenomenon to facilitate early diagnosis requires oculomotor assessment in prodromal cohorts.
Heidi C. Riek, Naomi P. Visanji, Isabell C. Pitigoi, Daniel G. Di Luca, Laura Armengou-Garcia, Nazish Ahmed, Julia E. Perkins, Donald C. Brien, Jeff Huang, Brian C. Coe, Jana Huang, Taneera Ghate, Anthony E. Lang, Connie Marras, Douglas P. Munoz   +14 more
doaj   +1 more source

Additional file 1: of Status of the Parkinsonâ s disease gene family expression in non-small-cell lung cancer

, 2015
Results of t -test for gender and histology.
Liu, Quan, Zheng, Hong, Deng, Xu, Zhou, Dong, Dai, Ji   +4 more
openaire   +1 more source

Functional Blood‐Brain Barrier Crossing by Biomimetic M13 Phage Vectors for Targeted Neuronal Delivery

Advanced Healthcare Materials, EarlyView.
This study investigates the M13 bacteriophage as a biomimetic nanovector capable of crossing in vitro models of the blood–brain barrier. By exploiting peculiar transcellular pathways, M13 avoids lysosomal degradation and preserves its structural integrity and functionality.
Silvia Vercellino, Lucia Pappagallo, Francesca De Chirico, Luca Boselli, Hazem Ahmed, Luca Spagnoletti, Giovanni Pittaluga, Paolo Emidio Costantini, Matteo Calvaresi, Pier Paolo Pompa, Alberto Danielli, Fabio Benfenati, Valentina Castagnola   +12 more
wiley   +1 more source

Additional file 2: of Cyclosporin promotes neurorestoration and cell replacement therapy in pre-clinical models of Parkinsonâ s disease

, 2015
Supplementary online material. (DOCX 119 kb)
Tamburrino, Anna, Churchill, Madeline, Oi Wan, Colino-Sanguino, Yolanda, Ippolito, Rossana, Bergstrand, Sofie, Wolf, Daniel, Niculin Herz, Sconce, Michelle, BjĂśrklund, Anders, Meshul, Charles, Decressac, Mickael   +11 more
openaire   +1 more source

Kelvin Probe Force Microscopy in Bionanotechnology: Current Advances and Future Perspectives

Advanced Materials, EarlyView.
Kelvin probe force microscopy (KPFM) enables the nanoscale mapping of electrostatic surface potentials. While widely applied in materials science, its use in biological systems remains emerging. This review presents recent advances in KPFM applied to biological samples and provides a critical perspective on current limitations and future directions for
Ehsan Rahimi, Mario Palacios‐Corella, Arjan Mol, Salvador Pané, Josep Puigmartí‐Luis   +4 more
wiley   +1 more source

Additional file 1: of Evaluation of rotigotine transdermal patch for the treatment of apathy and motor symptoms in Parkinsonâ s disease

, 2016
Institutional Review Boards or Independent Ethics Committees of participating sites in the PD0005 study. (PDF 220 kb)
Hauser, Robert, Jaroslaw Slawek, Barone, Paolo, Dohin, Elisabeth, Surmann, Erwin, Asgharnejad, Mahnaz, Bauer, Lars   +6 more
openaire   +1 more source

Bias‐Field Free Single‐Frequency CW‐ODMR of Nitrogen‐Vacancy Centers in Diamond for the Detection of Transient Electrical Signals

Advanced Materials Interfaces, EarlyView.
Simplified quantum sensing technique for the detection of short electrical signals occurring in neuronal signaling or bioinspired technologies. We demonstrate a single frequency continuous‐wave optically detected magnetic resonance (CW‐ODMR) approach to sense signals that can be as short as 0.2 ms.
João Paulo Silva, Orlando D. Cunha, Pedro Magalhães, Filipe Camarneiro, Jana B. Nieder   +4 more
wiley   +1 more source