Results 111 to 120 of about 223,878 (259)

Associação entre os níveis séricos de neopterina e a doença de Parkinson [PDF]

open access: yes, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde. Programa de Pós-Graduação em Ciências MédicasJustificativa: Evidências apontam para o envolvimento do sistema imune e neuroinflamação na gênese e progressão da ...
Freitas, Fernando Cini
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Cell‐Based Biohybrid Micro/Nanorobots for Biotherapy

open access: yesAdvanced Robotics Research, EarlyView.
This review systematically evaluates cell‐based biohybrid micro/nanorobots (CB‐BMRs), highlighting their cell selection criteria, fabrication strategies, and diverse actuation modes. Furthermore, it surveys the promising therapeutic applications of CB‐BMRs in targeted cancer, thrombosis, and inflammation treatments, while comprehensively discussing ...
Lin Wang   +11 more
wiley   +1 more source

NeuroSuite for Long‐Term Functional and Structural Studies of Air‐Liquid Interface Cerebral Organoids

open access: yesAdvanced Science, EarlyView.
NeuroSuite provides a modular hardware‐software platform integrating Neuroweb and NeuroMaps to enable long‐term, in situ electrophysiological interrogation of air–liquid interface organoid slices while preserving tissue architecture. Its components can be used together or independently to capture real‐time activity, spatial network dynamics, and ...
Belquis Haider   +14 more
wiley   +1 more source

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

open access: yesAdvanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao   +5 more
wiley   +1 more source

Parkinson\u27s disease and periodic limb movement in sleep

open access: yes, 2021
Parkinson\u27s disease is a neurodegenerative disease understood as a complex syndrome with motor and non-motor symptoms, including sleep-related conditions, such as periodic limb movements in sleep (PLMS).
Marques Alves, Iara Louise   +5 more
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Microglial Deubiquitinase OTUD7B Stabilizes STAT3 to Promote Neuroinflammation and Cognitive Decline in Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li   +15 more
wiley   +1 more source

Voyage autour du monde, sur le vaisseau de sa Majesté Britannique l'Endeavour, ... : précédé d'un discours en forme d'introduction sur les principaux navigateurs anglais et français qui ont précédé l'Endeavour : suivi d'un abrégé des deux derniers voyages du capitaine Cook

open access: yes
par Sydney Parkinson, dessinateur attaché à M. Banks ; ouvrage traduit de l'Anglais par le C. HenriTitelvignetteErscheinungsjahr nach Vorlage: An cinquième - 1797Drucker gemäss Vorsatz: A Paris : chez Guillame, rue du Bacq, no.
Parkinson, Sydney, [s.n.]
core   +1 more source

Gm26550 Modulates Learning and Memory by Increasing IGF1 mRNA Expression and Stability in Nrf2−/− Mice

open access: yesAdvanced Science, EarlyView.
The present study shows that Nrf2 directly binds to the Gm26550 promoter, thereby activating Gm26550 transcription and increasing its expression. Mechanistically, Gm26550 promotes IGF1 expression by functionally antagonizing miR‐26a‐5p‐mediated repression and sequestering the RBP KHSRP, thereby enhancing hippocampal neuronal synaptic plasticity and ...
Hongfang Wang   +12 more
wiley   +1 more source

Le Parkinson male [picture]

open access: yes
"Pl. 14"; Most likely after Sydney Parkinson.; Also available online at: http://nla.gov.au/nla.pic-an11135269 ...

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Clark Parkinson and family, Snow Basin ski area

open access: yes, 1990
Photo of Clark Parkinson and family at Snowbasin ski area, Weber County ...

core  

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