Results 131 to 140 of about 108,963 (268)

Polydopamine Nanoparticle‐Mediated Precise Near‐Infrared Optical Stimulation for Cognitive Enhancement

Advanced Science, EarlyView.
Polydopamine nanoparticles enable a precise, non‐genetic, and transcranial neuromodulation strategy via near‐infrared photothermal stimulation. By activating TRPV1 channels, this approach specifically enhances hippocampal gamma oscillations, thereby rescuing spatial memory deficits in models of perioperative neurocognitive disorder.
Yan‐Bo Zhou, Qiong Xue, Su‐Xuan Hou, Ke‐Yao Zhang, Wei‐Tong Pan, Ting‐Ting Zeng, Yu‐Ge Wang, Daqing Ma, Chenguang Zhao, Pan‐Miao Liu, Jian‐Jun Yang   +10 more
wiley   +1 more source

Ultrastructural and chemical analysis of human Locus coeruleus using correlative microscopy and mass spectrometry [PDF]

BIO Web of Conferences
Berro Zahraa, Subirana Maria Angels, Warres Clementine, Wirtz Tom, Taubitz Tatjana, Audinot Jean-Nicolas, Zucca Fabio A., Mittelbronn Michel, Zecca Luigi, Biesemeier Antje   +9 more
doaj   +1 more source

A scoping review of rapid-onset climate-related disasters & gender-based violence against women. [PDF]

Clim Risk Manag
Ruiz AM, Muñoz L, Walsh T, Hardy G, Ranjbari B, Contreras MM, Leslie SL, Nevitt M.   +7 more
europepmc   +1 more source

PolyG Fibrils Coalesce Into Nuclear Ribbons That Engage Proteostasis Machinery in Neuronal Intranuclear Inclusion Disease

Advanced Science, EarlyView.
In NIID, expanded NOTCH2NLC repeats give rise to nuclear polyG inclusions. Tracer‐guided in situ cryo‐electron tomography enables cross‐scale structural analysis from mouse brain to native neuronal nuclei, revealing dense‐core/peripheral‐halo inclusions built from compact polyG ribbons.
Hui Dong, Yongcheng Pan, Zhiyao Tang, Yuxuan Yao, Guicong Zhang, Junpu Wang, Haonan Xiao, Yun Tian, Beisha Tang, Dan Li, Qiang Guo, Ruijun Tian, Qiong Liu, Cong Liu   +13 more
wiley   +1 more source

True vignettes: interesting, illustrative examples of behavioral abnormalities in people with Parkinson's disease. [PDF]

Arq Neuropsiquiatr
Friedman JH, Akbar U, Beehler B, Chou KL, Cloud LJ, Deik A, Gilbert R, Gomperts SN, Goudreau JL, Gunzler SA, Lizarraga K, Malaty I, Maurer CW, Miyasaki J, Mohammed N, Morgan JC, Munhoz RP, Pal G, Shulman L, Simon D, Pontone G.   +20 more
europepmc   +1 more source

Highly Repeatable Fibrous Crack‐Based Strain Sensor for Multichannel Continuous Tremor Monitoring in Parkinson's Disease and Essential Tremor

Advanced Science, EarlyView.
This study proposes a patch‐type tremor monitoring system based on high‐repeatable fibrous crack‐based strain sensor, capable of simultaneously measuring tremor in multiple locations such as thumb, index, and wrist. Through clinical trials involving Parkinson's disease and essential tremor patients, the proposed system demonstrates its potential as a ...
Chiwon Song, Chan Park, Juyoun Lee, Hojoong Kim, Jeongbeom Kang, Byeongjun Lee, Cheoljeong Park, Jungmin Kim, Haran Lee, Yoon Jae Lee, Min‐Kyung Yeo, Woon‐Hong Yeo, Seong J. Cho   +12 more
wiley   +1 more source

[Dementia and Parkinson's Disease in the rural population of western Salamanca: a cross-sectional study of prevalence and family support needs]. [PDF]

Aten Primaria
Alonso Sardón M, Montes López E, Del Álamo Gómez N, Picado Valverde EM, Yurrebaso Macho A, Martín Delgado MA.   +5 more
europepmc   +1 more source

Trafficking Deficiency of TMEM175 Variants in Parkinson's Disease Pathogenesis and the Prospects of Precision Medicine

Advanced Science, EarlyView.
This study identifies that the PD‐associated TMEM175‐L156P variant disrupts lysosomal ion channel trafficking by causing aberrant endoplasmic reticulum retention. A “chaperone–agonist” bifunctional small molecule restores TMEM175‐L156P lysosomal localization and channel function, thereby alleviating PD‐relevant cellular phenotypes and highlighting a ...
Ting Luo, Yu He, Shuyao Li, Haoyu Guan, Ruili Cui, Yu Shi, Zhongwen Jiang, Siyu Wang, Xuan Li, Jiyuan Li, Mei Hu, Yupeng Zhou, Beisha Tang, Yanyan Zhang, Zhaobing Gao, Yu Zhou, Zhenhua Liu, Ping Li   +17 more
wiley   +1 more source

Human Foetal Neuroblasts Exhibit BK Channel‐Dependent Membrane Voltage Oscillations upon Depolarization

Advanced Science, EarlyView.
Primary cultures of neuroblasts isolated from the nucleus basalis of Meynert of 12‐weeks‐old human foetuses were prepared. Whole‐cell patch‐clamp recordings were performed by injecting a depolarizing stimulus current (+500 pA; 500 ms), and the membrane voltage recorded; this stimulus current evoked periodic‐like oscillations in membrane voltage ...
Elisabetta Coppi, Federica Cherchi, Martina Venturini, Federico Tommasi, Sandro Gonzi, Chiara Capacci, Giulia Guarnieri, Pasquale Gallina, Annamaria Morelli, Anna Maria Pugliese   +9 more
wiley   +1 more source

Post-marketing safety concerns with foscarbidopa/foslevodopa: A pharmacovigilance study with disproportionality analysis based on FAERS. [PDF]

Medicine (Baltimore)
Peng Y, Ding A, Zhang S, Kong F, Wu L, Sun W, Sun Z, Zheng X, Xi Y.   +8 more
europepmc   +1 more source