Results 101 to 110 of about 693,546 (355)

Spotlight on opicapone as an adjunct to levodopa in Parkinson’s disease: design, development and potential place in therapy

Drug Design, Development and Therapy, 2017
Ádám Annus,1 László Vécsei1,2 1Department of Neurology, Faculty of Medicine, Albert Szent-Györgyi Clinical Center, University of Szeged, 2MTA-SZTE Neuroscience Research Group, Szeged, Hungary Abstract: Parkinson ...
Annus Á, Vécsei L
doaj  

Research Priorities on the Role of α‐Synuclein in Parkinson's Disease Pathogenesis

Movement Disorders
Various forms of Parkinson's disease, including its common sporadic form, are characterized by prominent α‐synuclein (αSyn) aggregation in affected brain regions. However, the role of αSyn in the pathogenesis and evolution of the disease remains unclear,
Jacqueline Burré, Robert H. Edwards, G. Halliday, Anthony E. Lang, Hilal A. Lashuel, R. Melki, Shigeo Murayama, T. Outeiro, Stella M Papa, Leonidas Stefanis, A. Woerman, D. Surmeier, L. Kalia, Ryosuke Takahashi   +13 more
semanticscholar   +1 more source

Neuropsychiatric Symptoms Mimicking Dementia in a Patient Treated With Imatinib

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Tyrosine kinase inhibitors are the cornerstone of chronic myeloid leukemia treatment. Newer agents have more potency and a broader spectrum of action, but also a higher potential for neuropsychiatric side effects. We present a case of a patient on imatinib who developed progressive cognitive, mood, and behavioral alterations.
Ashley Jones, Samuele Bonomi, Keith E. Stockerl‐Goldstein, Randall J. Bateman   +3 more
wiley   +1 more source

Disease modifying therapy for multiple system atrophy – Parkinsonian Type [PDF]

, 2017
BACKGROUND: Multiple System Atrophy –Parkinsonian Type (MSA-P) is a rare, rapidly progressive neurodegenerative disease without any current treatment.
Dwyer, Sean Sullivan
core  

Spongionella secondary metabolites protect mitochondrial function in cortical neurons against oxidative stress [PDF]

, 2014
Accepted: 8 January 2014 This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Acknowledgments
Alfonso, Amparo, Alonso, Eva, Botana, Luis M, Ebel, Rainer, Houssen, Wael E, Jaspars, Marcel, Leirós, Marta, Rateb, Mostafa E, Rateb, Mostafa Ezzat Mohamed, Sánchez, Jon A   +9 more
core   +4 more sources

Deep Brain Stimulation of the Subthalamic Nucleus in Patients with Parkinson Disease with Prior Pallidotomy or Thalamotomy

Brain Sciences, 2018
Objective. To evaluate the efficacy of deep brain stimulation of the subthalamic nucleus (STN DBS) in patients with Parkinson disease (PD) who previously underwent lesioning of the basal ganglia. Material and methods.
Elena A. Khabarova, Natalia P. Denisova, Aleksandr B. Dmitriev, Konstantin V. Slavin, Leo Verhagen Metman   +4 more
doaj   +1 more source

Lucio’s phenomenon in untreated advanced leprosy

Human Pathology: Case Reports, 2020
A 77-year-old woman with underlying diabetes mellitus, hypertension and Parkinson disease presented to the emergency department with burn injury after dipping her foot into hot water. She was admitted with 75% dermal thickness burn of bilateral foot.
Nurwahyuna Rosli
doaj   +1 more source

Parkinson's disease secondary to COVID-19: a systematic review

, 2022
Objetivo: O presente trabalho teve como objetivo realizar uma revisão sistemática a respeito da Doença de Parkinson e sua relação com a COVID-19. Métodos: Utilizamos e adaptamos os critérios presentes no PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) e objetivou a identificação de publicações revisadas por pares ...
Hamoy, Moises, Braga, Gabriel Hans Reis, Chaves, Jones Vinicius Santana, Maia, Ana Carolina Serrão, Cabral, Diego Arthur Castro, Campos, Fernanda Myllena Sousa, Medeiros, João Paulo do Vale, Cabral, Leonardo Giovanni Castro, Oliveira, Bruno Patricio dos Santos, Braga, Joyce Pantoja, de Mello, Vanessa Jóia, Paschoal, Eric Homero Albuquerque   +11 more
openaire   +1 more source

Clinically Relevant Outcome Measures in Women With Adrenoleukodystrophy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Adrenoleukodystrophy is a rare inherited peroxisomal disease caused by pathogenic variants in the ABCD1 gene located on the X chromosome. Although the most severe central nervous system and adrenal complications typically affect only men with adrenoleukodystrophy, the majority of women develop myeloneuropathy symptoms in adulthood.
Chenwei Yan, Elizabeth I. Pierpont, Amena S. Fine, Reena V. Kartha   +3 more
wiley   +1 more source

SUR1 Receptor Interaction with Hesperidin and Linarin Predicts Possible Mechanisms of Action of Valeriana officinalis in Parkinson. [PDF]

, 2016
Parkinson's disease (PD) is one of the most common neurodegenerative disorders. A theoretical approach of our previous experiments reporting the cytoprotective effects of the Valeriana officinalis compounds extract for PD is suggested.
Andrade, Bruno, Barreto, George E., Capani, Francisco, Galembeck, Eduardo, Giraldez Alvarez, Lisandro Diego, Gôes Neto, Aristóteles, Santos, Gesivaldo, Ávila Rodriguez, Marco   +7 more
core   +4 more sources